Efflux as a mechanism for drug resistance in mycobacterium tuberculosis

Detalhes bibliográficos
Autor(a) principal: Silva, Pedro Eduardo Almeida da
Data de Publicação: 2011
Outros Autores: Groll, Andrea Von, Martin, Anandi, Palomino, Juan Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FURG (RI FURG)
Texto Completo: http://repositorio.furg.br/handle/1/7026
http://dx.doi.org/10.1111/j.1574-695X.2011.00831.x
Resumo: Tuberculosis remains an important global public health problem, with an estimated prevalence of 14 million individuals with tuberculosis worldwide in 2007. Because antibiotic treatment is one of the main tools for tuberculosis control, knowledge of Mycobacterium tuberculosis drug resistance is an important component for the disease control strategy. Although several gene mutations in specific loci of the M. tuberculosis genome have been reported as the basis for drug resistance, additional resistance mechanisms are now believed to exist. Efflux is a ubiquitous mechanism responsible for intrinsic and acquired drug resistance in prokaryotic and eukaryotic cells. Mycobacterium tuberculosis presents one of the largest numbers of putative drug efflux pumps compared with its genome size. Bioinformatics as well as direct and indirect evidence have established relationships among drug efflux with intrinsic or acquired resistance in M. tuberculosis. This minireview describes the current knowledge on drug efflux in M. tuberculosis.
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spelling Silva, Pedro Eduardo Almeida daGroll, Andrea VonMartin, AnandiPalomino, Juan Carlos2017-01-17T13:24:52Z2017-01-17T13:24:52Z2011SILVA, Pedro Eduardo Almeida da et al. Efflux as a mechanism for drug resistance in mycobacterium tuberculosis. FEMS Immunology and Medical Microbiology, v. 63, n. 1, p. 1-9, 2011. Disponível em: <http://femsim.oxfordjournals.org/content/63/1/1>. Acesso em: 16 jan. 20l7.1574-695Xhttp://repositorio.furg.br/handle/1/7026http://dx.doi.org/10.1111/j.1574-695X.2011.00831.xTuberculosis remains an important global public health problem, with an estimated prevalence of 14 million individuals with tuberculosis worldwide in 2007. Because antibiotic treatment is one of the main tools for tuberculosis control, knowledge of Mycobacterium tuberculosis drug resistance is an important component for the disease control strategy. Although several gene mutations in specific loci of the M. tuberculosis genome have been reported as the basis for drug resistance, additional resistance mechanisms are now believed to exist. Efflux is a ubiquitous mechanism responsible for intrinsic and acquired drug resistance in prokaryotic and eukaryotic cells. Mycobacterium tuberculosis presents one of the largest numbers of putative drug efflux pumps compared with its genome size. Bioinformatics as well as direct and indirect evidence have established relationships among drug efflux with intrinsic or acquired resistance in M. tuberculosis. This minireview describes the current knowledge on drug efflux in M. tuberculosis.engTuberculosisDrug resistanceEffluxTransportersATP-binding cassettePumpsEfflux as a mechanism for drug resistance in mycobacterium tuberculosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINAL1.full.pdf1.full.pdfapplication/pdf115961https://repositorio.furg.br/bitstream/1/7026/1/1.full.pdf4386d73f02ab9b9466ec33eec589ae7eMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.furg.br/bitstream/1/7026/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52open access1/70262017-01-17 11:24:52.907open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2017-01-17T13:24:52Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false
dc.title.pt_BR.fl_str_mv Efflux as a mechanism for drug resistance in mycobacterium tuberculosis
title Efflux as a mechanism for drug resistance in mycobacterium tuberculosis
spellingShingle Efflux as a mechanism for drug resistance in mycobacterium tuberculosis
Silva, Pedro Eduardo Almeida da
Tuberculosis
Drug resistance
Efflux
Transporters
ATP-binding cassette
Pumps
title_short Efflux as a mechanism for drug resistance in mycobacterium tuberculosis
title_full Efflux as a mechanism for drug resistance in mycobacterium tuberculosis
title_fullStr Efflux as a mechanism for drug resistance in mycobacterium tuberculosis
title_full_unstemmed Efflux as a mechanism for drug resistance in mycobacterium tuberculosis
title_sort Efflux as a mechanism for drug resistance in mycobacterium tuberculosis
author Silva, Pedro Eduardo Almeida da
author_facet Silva, Pedro Eduardo Almeida da
Groll, Andrea Von
Martin, Anandi
Palomino, Juan Carlos
author_role author
author2 Groll, Andrea Von
Martin, Anandi
Palomino, Juan Carlos
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva, Pedro Eduardo Almeida da
Groll, Andrea Von
Martin, Anandi
Palomino, Juan Carlos
dc.subject.por.fl_str_mv Tuberculosis
Drug resistance
Efflux
Transporters
ATP-binding cassette
Pumps
topic Tuberculosis
Drug resistance
Efflux
Transporters
ATP-binding cassette
Pumps
description Tuberculosis remains an important global public health problem, with an estimated prevalence of 14 million individuals with tuberculosis worldwide in 2007. Because antibiotic treatment is one of the main tools for tuberculosis control, knowledge of Mycobacterium tuberculosis drug resistance is an important component for the disease control strategy. Although several gene mutations in specific loci of the M. tuberculosis genome have been reported as the basis for drug resistance, additional resistance mechanisms are now believed to exist. Efflux is a ubiquitous mechanism responsible for intrinsic and acquired drug resistance in prokaryotic and eukaryotic cells. Mycobacterium tuberculosis presents one of the largest numbers of putative drug efflux pumps compared with its genome size. Bioinformatics as well as direct and indirect evidence have established relationships among drug efflux with intrinsic or acquired resistance in M. tuberculosis. This minireview describes the current knowledge on drug efflux in M. tuberculosis.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2017-01-17T13:24:52Z
dc.date.available.fl_str_mv 2017-01-17T13:24:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Pedro Eduardo Almeida da et al. Efflux as a mechanism for drug resistance in mycobacterium tuberculosis. FEMS Immunology and Medical Microbiology, v. 63, n. 1, p. 1-9, 2011. Disponível em: <http://femsim.oxfordjournals.org/content/63/1/1>. Acesso em: 16 jan. 20l7.
dc.identifier.uri.fl_str_mv http://repositorio.furg.br/handle/1/7026
dc.identifier.issn.none.fl_str_mv 1574-695X
dc.identifier.doi.pt_BR.fl_str_mv http://dx.doi.org/10.1111/j.1574-695X.2011.00831.x
identifier_str_mv SILVA, Pedro Eduardo Almeida da et al. Efflux as a mechanism for drug resistance in mycobacterium tuberculosis. FEMS Immunology and Medical Microbiology, v. 63, n. 1, p. 1-9, 2011. Disponível em: <http://femsim.oxfordjournals.org/content/63/1/1>. Acesso em: 16 jan. 20l7.
1574-695X
url http://repositorio.furg.br/handle/1/7026
http://dx.doi.org/10.1111/j.1574-695X.2011.00831.x
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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reponame_str Repositório Institucional da FURG (RI FURG)
collection Repositório Institucional da FURG (RI FURG)
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