Regulation of Cognitive Processing by Hippocampal Cholinergic Tone
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/7395 |
Resumo: | Cholinergic dysfunction has been associated with cognitive abnormalities in a variety of neurodegenerative and neuropsychiatric diseases. Here we tested how information processing is regulated by cholinergic tone in genetically modified mice targeting the vesicular acetylcholine transporter (VAChT), a protein required for acetylcholine release. We measured longterm potentiation of Schaffer collateral-CA1 synapses in vivo and assessed information processing by using a mouse touchscreen version of paired associates learning task (PAL). Acquisition of information in the mouse PAL task correlated to levels of hippocampal VAChT, suggesting a critical role for cholinergic tone. Accordingly, synaptic plasticity in the hippocampus in vivo was disturbed, but not completely abolished, by decreased hippocampal cholinergic signaling. Disrupted forebrain cholinergic signaling also affected working memory, a result reproduced by selectively decreasing VAChT in the hippocampus. In contrast, spatial memory was relatively preserved, whereas reversal spatial memory was sensitive to decreased hippocampal cholinergic signaling. This work provides a refined roadmap of how synaptically secreted acetylcholine influences distinct behaviors and suggests that distinct forms of cognitive processing may be regulated in different ways by cholinergic activity. |
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Repositório Institucional da FURG (RI FURG) |
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Regulation of Cognitive Processing by Hippocampal Cholinergic ToneAlzheimer’s diseaseLong-term potentiationMorris water mazePaired associates learningVesicular acetylcholine transporterWorking memoryCholinergic dysfunction has been associated with cognitive abnormalities in a variety of neurodegenerative and neuropsychiatric diseases. Here we tested how information processing is regulated by cholinergic tone in genetically modified mice targeting the vesicular acetylcholine transporter (VAChT), a protein required for acetylcholine release. We measured longterm potentiation of Schaffer collateral-CA1 synapses in vivo and assessed information processing by using a mouse touchscreen version of paired associates learning task (PAL). Acquisition of information in the mouse PAL task correlated to levels of hippocampal VAChT, suggesting a critical role for cholinergic tone. Accordingly, synaptic plasticity in the hippocampus in vivo was disturbed, but not completely abolished, by decreased hippocampal cholinergic signaling. Disrupted forebrain cholinergic signaling also affected working memory, a result reproduced by selectively decreasing VAChT in the hippocampus. In contrast, spatial memory was relatively preserved, whereas reversal spatial memory was sensitive to decreased hippocampal cholinergic signaling. This work provides a refined roadmap of how synaptically secreted acetylcholine influences distinct behaviors and suggests that distinct forms of cognitive processing may be regulated in different ways by cholinergic activity.2017-07-19T17:50:36Z2017-07-19T17:50:36Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAL-ONAIZI, Mohammed et al. Regulation of Cognitive Processing by Hippocampal Cholinergic Tone. Cerebral Cortex (New York, N.Y. 1991), v. 27, n. 2, p. 615–1628, 2016. Disponível em:< https://academic.oup.com/cercor/article/27/2/1615/3056290/Regulation-of-Cognitive-Processing-by-Hippocampal>. Acesso em: 15 abr. 2017.1047-3211http://repositorio.furg.br/handle/1/739510.1093/cercor/bhv349engAl-Onaizi, MohammedParfitt, Gustavo MorroneKolisnyk, BenjaminLaw, Clayton S. H.Guzman, MonicaBarros, Daniela MartiLeung, L. StanPrado, Marco Antonio MaximoPrado, Vania Ferreirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2023-11-14T12:59:09Zoai:repositorio.furg.br:1/7395Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2023-11-14T12:59:09Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.none.fl_str_mv |
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone |
title |
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone |
spellingShingle |
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone Al-Onaizi, Mohammed Alzheimer’s disease Long-term potentiation Morris water maze Paired associates learning Vesicular acetylcholine transporter Working memory |
title_short |
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone |
title_full |
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone |
title_fullStr |
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone |
title_full_unstemmed |
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone |
title_sort |
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone |
author |
Al-Onaizi, Mohammed |
author_facet |
Al-Onaizi, Mohammed Parfitt, Gustavo Morrone Kolisnyk, Benjamin Law, Clayton S. H. Guzman, Monica Barros, Daniela Marti Leung, L. Stan Prado, Marco Antonio Maximo Prado, Vania Ferreira |
author_role |
author |
author2 |
Parfitt, Gustavo Morrone Kolisnyk, Benjamin Law, Clayton S. H. Guzman, Monica Barros, Daniela Marti Leung, L. Stan Prado, Marco Antonio Maximo Prado, Vania Ferreira |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Al-Onaizi, Mohammed Parfitt, Gustavo Morrone Kolisnyk, Benjamin Law, Clayton S. H. Guzman, Monica Barros, Daniela Marti Leung, L. Stan Prado, Marco Antonio Maximo Prado, Vania Ferreira |
dc.subject.por.fl_str_mv |
Alzheimer’s disease Long-term potentiation Morris water maze Paired associates learning Vesicular acetylcholine transporter Working memory |
topic |
Alzheimer’s disease Long-term potentiation Morris water maze Paired associates learning Vesicular acetylcholine transporter Working memory |
description |
Cholinergic dysfunction has been associated with cognitive abnormalities in a variety of neurodegenerative and neuropsychiatric diseases. Here we tested how information processing is regulated by cholinergic tone in genetically modified mice targeting the vesicular acetylcholine transporter (VAChT), a protein required for acetylcholine release. We measured longterm potentiation of Schaffer collateral-CA1 synapses in vivo and assessed information processing by using a mouse touchscreen version of paired associates learning task (PAL). Acquisition of information in the mouse PAL task correlated to levels of hippocampal VAChT, suggesting a critical role for cholinergic tone. Accordingly, synaptic plasticity in the hippocampus in vivo was disturbed, but not completely abolished, by decreased hippocampal cholinergic signaling. Disrupted forebrain cholinergic signaling also affected working memory, a result reproduced by selectively decreasing VAChT in the hippocampus. In contrast, spatial memory was relatively preserved, whereas reversal spatial memory was sensitive to decreased hippocampal cholinergic signaling. This work provides a refined roadmap of how synaptically secreted acetylcholine influences distinct behaviors and suggests that distinct forms of cognitive processing may be regulated in different ways by cholinergic activity. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-07-19T17:50:36Z 2017-07-19T17:50:36Z 2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
AL-ONAIZI, Mohammed et al. Regulation of Cognitive Processing by Hippocampal Cholinergic Tone. Cerebral Cortex (New York, N.Y. 1991), v. 27, n. 2, p. 615–1628, 2016. Disponível em:< https://academic.oup.com/cercor/article/27/2/1615/3056290/Regulation-of-Cognitive-Processing-by-Hippocampal>. Acesso em: 15 abr. 2017. 1047-3211 http://repositorio.furg.br/handle/1/7395 10.1093/cercor/bhv349 |
identifier_str_mv |
AL-ONAIZI, Mohammed et al. Regulation of Cognitive Processing by Hippocampal Cholinergic Tone. Cerebral Cortex (New York, N.Y. 1991), v. 27, n. 2, p. 615–1628, 2016. Disponível em:< https://academic.oup.com/cercor/article/27/2/1615/3056290/Regulation-of-Cognitive-Processing-by-Hippocampal>. Acesso em: 15 abr. 2017. 1047-3211 10.1093/cercor/bhv349 |
url |
http://repositorio.furg.br/handle/1/7395 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
instname_str |
Universidade Federal do Rio Grande (FURG) |
instacron_str |
FURG |
institution |
FURG |
reponame_str |
Repositório Institucional da FURG (RI FURG) |
collection |
Repositório Institucional da FURG (RI FURG) |
repository.name.fl_str_mv |
Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG) |
repository.mail.fl_str_mv |
|
_version_ |
1807384397950746624 |