Antiproliferative and genotoxic potential from extracts and fractions of Richardia brasiliensis Gomes (Rubiaceae) by the Allium cepa L. test system
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Iheringia. Série Botânica |
Texto Completo: | https://isb.emnuvens.com.br/iheringia/article/view/659 |
Resumo: | The medicinal species Richardia brasiliensis Gomes has secondary metabolites with considerable pharmacological activities. This study aims to determine the antiproliferative and genotoxic capacity of extracts and fractions obtained from the aerial parts of R. brasiliensis, in the Allium cepa test, on which one can detect the damages on chromosomes and the infl uence on cell proliferation during the mitotic cycle. The antiproliferative and genotoxic eff ect from extracts and fractions were evaluated at concentrations of 10 and 500 µg/mL and the mitotic index (MI) and the percentage of chromosomal alterations (CA) were calculated and used on the χ² test. It was observed antiproliferative capacity, the best results were from the autumn crude extract, and the hexane and butanol fractions with lower MI than the negative control. All treatments were genotoxic with CA, but with lower values than the ones found in the positive control. |
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Iheringia. Série Botânica |
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Antiproliferative and genotoxic potential from extracts and fractions of Richardia brasiliensis Gomes (Rubiaceae) by the Allium cepa L. test systemThe medicinal species Richardia brasiliensis Gomes has secondary metabolites with considerable pharmacological activities. This study aims to determine the antiproliferative and genotoxic capacity of extracts and fractions obtained from the aerial parts of R. brasiliensis, in the Allium cepa test, on which one can detect the damages on chromosomes and the infl uence on cell proliferation during the mitotic cycle. The antiproliferative and genotoxic eff ect from extracts and fractions were evaluated at concentrations of 10 and 500 µg/mL and the mitotic index (MI) and the percentage of chromosomal alterations (CA) were calculated and used on the χ² test. It was observed antiproliferative capacity, the best results were from the autumn crude extract, and the hexane and butanol fractions with lower MI than the negative control. All treatments were genotoxic with CA, but with lower values than the ones found in the positive control.Iheringia. Série Botânica.Iheringia, Série Botânica.2018-01-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://isb.emnuvens.com.br/iheringia/article/view/659Iheringia. Série Botânica.; Vol. 72 No. 3 (2017); 424-431Iheringia, Série Botânica.; v. 72 n. 3 (2017); 424-4312446-82310073-4705reponame:Iheringia. Série Botânicainstname:Fundação Zoobotânica do Rio Grande do Sul (FZB/RS)instacron:FZB/RSporhttps://isb.emnuvens.com.br/iheringia/article/view/659/377Copyright (c) 2018 Iheringia. Série Botânica.info:eu-repo/semantics/openAccessDornelles, Rafaela C.Leal, Gabriela C.Decian, Ana Carla S.Santos, Daniele D. dosRadiske, Gabriel A.Manfron, Melânia P.Tedesco, Solange B.2018-07-04T18:52:25Zoai:ojs.emnuvens.com.br:article/659Revistahttps://isb.emnuvens.com.br/iheringiaONGhttps://isb.emnuvens.com.br/iheringia/oai||iheringia-bot@fzb.rs.gov.br2446-82310073-4705opendoar:2018-07-04T18:52:25Iheringia. Série Botânica - Fundação Zoobotânica do Rio Grande do Sul (FZB/RS)false |
dc.title.none.fl_str_mv |
Antiproliferative and genotoxic potential from extracts and fractions of Richardia brasiliensis Gomes (Rubiaceae) by the Allium cepa L. test system |
title |
Antiproliferative and genotoxic potential from extracts and fractions of Richardia brasiliensis Gomes (Rubiaceae) by the Allium cepa L. test system |
spellingShingle |
Antiproliferative and genotoxic potential from extracts and fractions of Richardia brasiliensis Gomes (Rubiaceae) by the Allium cepa L. test system Dornelles, Rafaela C. |
title_short |
Antiproliferative and genotoxic potential from extracts and fractions of Richardia brasiliensis Gomes (Rubiaceae) by the Allium cepa L. test system |
title_full |
Antiproliferative and genotoxic potential from extracts and fractions of Richardia brasiliensis Gomes (Rubiaceae) by the Allium cepa L. test system |
title_fullStr |
Antiproliferative and genotoxic potential from extracts and fractions of Richardia brasiliensis Gomes (Rubiaceae) by the Allium cepa L. test system |
title_full_unstemmed |
Antiproliferative and genotoxic potential from extracts and fractions of Richardia brasiliensis Gomes (Rubiaceae) by the Allium cepa L. test system |
title_sort |
Antiproliferative and genotoxic potential from extracts and fractions of Richardia brasiliensis Gomes (Rubiaceae) by the Allium cepa L. test system |
author |
Dornelles, Rafaela C. |
author_facet |
Dornelles, Rafaela C. Leal, Gabriela C. Decian, Ana Carla S. Santos, Daniele D. dos Radiske, Gabriel A. Manfron, Melânia P. Tedesco, Solange B. |
author_role |
author |
author2 |
Leal, Gabriela C. Decian, Ana Carla S. Santos, Daniele D. dos Radiske, Gabriel A. Manfron, Melânia P. Tedesco, Solange B. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Dornelles, Rafaela C. Leal, Gabriela C. Decian, Ana Carla S. Santos, Daniele D. dos Radiske, Gabriel A. Manfron, Melânia P. Tedesco, Solange B. |
description |
The medicinal species Richardia brasiliensis Gomes has secondary metabolites with considerable pharmacological activities. This study aims to determine the antiproliferative and genotoxic capacity of extracts and fractions obtained from the aerial parts of R. brasiliensis, in the Allium cepa test, on which one can detect the damages on chromosomes and the infl uence on cell proliferation during the mitotic cycle. The antiproliferative and genotoxic eff ect from extracts and fractions were evaluated at concentrations of 10 and 500 µg/mL and the mitotic index (MI) and the percentage of chromosomal alterations (CA) were calculated and used on the χ² test. It was observed antiproliferative capacity, the best results were from the autumn crude extract, and the hexane and butanol fractions with lower MI than the negative control. All treatments were genotoxic with CA, but with lower values than the ones found in the positive control. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-12 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://isb.emnuvens.com.br/iheringia/article/view/659 |
url |
https://isb.emnuvens.com.br/iheringia/article/view/659 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://isb.emnuvens.com.br/iheringia/article/view/659/377 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Iheringia. Série Botânica. info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Iheringia. Série Botânica. |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Iheringia. Série Botânica. Iheringia, Série Botânica. |
publisher.none.fl_str_mv |
Iheringia. Série Botânica. Iheringia, Série Botânica. |
dc.source.none.fl_str_mv |
Iheringia. Série Botânica.; Vol. 72 No. 3 (2017); 424-431 Iheringia, Série Botânica.; v. 72 n. 3 (2017); 424-431 2446-8231 0073-4705 reponame:Iheringia. Série Botânica instname:Fundação Zoobotânica do Rio Grande do Sul (FZB/RS) instacron:FZB/RS |
instname_str |
Fundação Zoobotânica do Rio Grande do Sul (FZB/RS) |
instacron_str |
FZB/RS |
institution |
FZB/RS |
reponame_str |
Iheringia. Série Botânica |
collection |
Iheringia. Série Botânica |
repository.name.fl_str_mv |
Iheringia. Série Botânica - Fundação Zoobotânica do Rio Grande do Sul (FZB/RS) |
repository.mail.fl_str_mv |
||iheringia-bot@fzb.rs.gov.br |
_version_ |
1798948135881408512 |