CELL-PROTEIN-IMPLANT INTERACTION IN THE OSSEOINTEGRATION PROCESS: CELL-PROTEIN-IMPLANT INTERACTION

• Autor(a) principal: Nascimento, Marvin
• Data de Publicação: 2022
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/198
• topic: osseointegração; fibrointegração; biomateriais; implantes dentários; osseointegration; fibrointegration; biomaterials; dental implants

Introduction: dental implants are biomaterials that have high biocompatibility and are highly promising as surgical-rehabilitating devices in dentistry. However, some these biomaterials properties such as composition, design and surface morphology need to be considered in order to achieve good osseointegration, not fibrointegration. Objective: this review seeks to elucidate the interaction mechanisms between cells and proteins with the dental implants surfaces. Materials and Methods: The research consisted of a qualitative bias in English and Portuguese in PubMed (MEDLINE), Bireme (LILACS) and Academic Google. Results: After implantation, the angiogenesis process will occur at first and then the regeneration of other tissues (bone formation and neoformation), characterizing osseointegration. However, if there is no biocompatibility, the cellular response will characterize a foreign body response (fibrointegration). Furthermore, in the nanoscale osseointegration process, a protein anchorage is formed between the periosteum and the implant, and the integrin, which is a transmembrane protein, plays a key role in this process, mediating these connections. Conclusion: It can be concluded that these interactions between cells-proteins-implants are essential for a better understanding of the cellular responses of dental implants and the role of proteins, with emphasis on integrin, which will mediate the osseointegration process.