THE RISK OF POISONING FROM THE USE OF OZEMPIC (SEMAGLUTIDE) IN NON-DIABETIC PATIENTS
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/501 |
Resumo: | Ozempic (semaglutide), a glucagon-like peptide-1 (GLP-1) receptor agonist originally used in the treatment of type 2 diabetes, has generated interest as a new approach to reducing obesity, as studies point to a high efficacy in reducing systolic blood pressure in obese patients, weight loss and a slight reduction in diastolic blood pressure. The objective of this systematic review was to find out what are the possible adverse effects caused by Semaglutide in patients who do not have DM2, since there are still few studies regarding the toxicity of the drug in non-diabetic patients. According to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines, the databases of the Pubmed and Scielo libraries were systematically used for all studies in this review. Meta-analyses, systematic reviews and randomized clinical trials that addressed the topic between 2012 and 2023 were included. Although the analyzed studies demonstrated efficacy in the use of semaglutide, mainly in non-diabetic obese patients, adverse effects were observed, mainly gastrointestinal, among them there are vomiting, nausea, diarrhea and abdominal pain, mild to moderate, in all analyzed studies, and should be taken into account before using and indicating the drug. It is also necessary for health professionals to follow up more closely and take greater care with patients who already have some type of comorbidity and who may be affected by the adverse effects of the medication. More long-term studies on the use of Ozempic in non-diabetic patients are still needed to be more certain about its toxicity. |
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THE RISK OF POISONING FROM THE USE OF OZEMPIC (SEMAGLUTIDE) IN NON-DIABETIC PATIENTSEL RIESGO DE ENVENENAMIENTO POR EL USO DE OZEMPIC (SEMAGLUTIDA) EN PACIENTES NO DIABÉTICOSO RISCO DE INTOXICAÇÃO PELO USO DO OZEMPIC (SEMAGLUTIDA) EM PACIENTES NÃO DIABÉTICOSOzempic, Semaglutida, diabetes, emagrecimento e intoxicação medicamentosaOzempic, Semaglutide, diabetes, weight loss and drug intoxicationOzempic, Semaglutida, diabetes, pérdida de peso e intoxicación por fármacosOzempic (semaglutide), a glucagon-like peptide-1 (GLP-1) receptor agonist originally used in the treatment of type 2 diabetes, has generated interest as a new approach to reducing obesity, as studies point to a high efficacy in reducing systolic blood pressure in obese patients, weight loss and a slight reduction in diastolic blood pressure. The objective of this systematic review was to find out what are the possible adverse effects caused by Semaglutide in patients who do not have DM2, since there are still few studies regarding the toxicity of the drug in non-diabetic patients. According to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines, the databases of the Pubmed and Scielo libraries were systematically used for all studies in this review. Meta-analyses, systematic reviews and randomized clinical trials that addressed the topic between 2012 and 2023 were included. Although the analyzed studies demonstrated efficacy in the use of semaglutide, mainly in non-diabetic obese patients, adverse effects were observed, mainly gastrointestinal, among them there are vomiting, nausea, diarrhea and abdominal pain, mild to moderate, in all analyzed studies, and should be taken into account before using and indicating the drug. It is also necessary for health professionals to follow up more closely and take greater care with patients who already have some type of comorbidity and who may be affected by the adverse effects of the medication. More long-term studies on the use of Ozempic in non-diabetic patients are still needed to be more certain about its toxicity.Ozempic (semaglutida), un agonista del receptor del péptido similar al glucagón-1 (GLP-1) utilizado originalmente en el tratamiento de la diabetes tipo 2, ha generado interés como un nuevo enfoque para reducir la obesidad, ya que los estudios apuntan a una alta eficacia en la reducción de la presión sistólica. presión arterial en pacientes obesos, pérdida de peso y una ligera reducción de la presión arterial diastólica. El objetivo de esta revisión sistemática fue conocer cuáles son los posibles efectos adversos que provoca la Semaglutida en pacientes que no tienen DM2, ya que aún existen pocos estudios respecto a la toxicidad del fármaco en pacientes no diabéticos. De acuerdo con las pautas PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis), las bases de datos de las bibliotecas Pubmed y Scielo se utilizaron sistemáticamente para todos los estudios de esta revisión. Se incluyeron metaanálisis, revisiones sistemáticas y ensayos clínicos aleatorios que abordaron el tema entre 2012 y 2023. Si bien los estudios analizados demostraron eficacia en el uso de semaglutida, principalmente en pacientes obesos no diabéticos, se observaron efectos adversos, principalmente gastrointestinales, entre ellos vómitos, náuseas, diarrea y dolor abdominal, de leves a moderados, en todos los estudios analizados. y debe tenerse en cuenta antes de utilizar e indicar el medicamento. También es necesario que los profesionales de la salud realicen un seguimiento más cercano y tengan mayor cuidado con los pacientes que ya presentan algún tipo de comorbilidad y que pueden verse afectados por los efectos adversos de la medicación. Aún se necesitan más estudios a largo plazo sobre el uso de Ozempic en pacientes no diabéticos para tener más certeza sobre su toxicidad.O Ozempic (semaglutida), um agonista do receptor do peptídeo-1 semelhante ao glucagon (GLP-1), originalmente utilizado no tratamento do diabetes tipo 2, tem gerado interesse como uma nova abordagem para diminuição da obesidade, visto que estudos apontam uma alta eficácia na redução da pressão arterial sistólica em pacientes obesos, diminuição do peso e uma leve redução na pressão arterial diastólica. O objetivo desta revisão sistemática, foi averiguar quais os possíveis efeitos adversos provocados pela Semaglutida em pacientes que não possuem a DM2, uma vez que, ainda há poucos estudos a respeito da toxicidade do medicamento em pacientes não diabéticos. De acordo com as diretrizes PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis), as bases de dados das bibliotecas Pubmed e Scielo foram sistematicamente utilizadas para todos os estudos dessa revisão. Foram incluídas meta-análises, revisões sistemáticas e ensaios clínicos randomizados que abordaram a temática entre 2012 e 2023. Embora os estudos analisados tenham demonstrado eficácia no uso da semaglutida, principalmente em pacientes obesos não diabéticos, foram observados efeitos adversos, principalmente gastrointestinais, dentre eles estão vômitos, náuseas, diarréia e dores abdominais, leve a moderados, em todos os estudos analisados, devendo ser levados em consideração antes da utilização e da indicação do medicamento. É necessário ainda que os profissionais da saúde façam um acompanhamento mais próximo e um maior cuidado com pacientes que já possuem algum tipo de comorbidade e que possam ser afetados pelos efeitos adversos do medicamento. Ainda se faz necessário mais estudos a longo prazo sobre o uso do Ozempic em pacientes não diabéticos para uma maior certeza sobre sua toxicidade.Specialized Dentistry Group2023-09-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/50110.36557/2674-8169.2023v5n4p1826-1837Brazilian Journal of Implantology and Health Sciences ; Vol. 5 No. 4 (2023): BJIHS QUALIS B3; 1826-1837Brazilian Journal of Implantology and Health Sciences ; Vol. 5 Núm. 4 (2023): BJIHS QUALIS B3; 1826-1837Brazilian Journal of Implantology and Health Sciences ; v. 5 n. 4 (2023): BJIHS QUALIS B3; 1826-18372674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/501/619Copyright (c) 2023 Rebecka Marques Gomes Sagratzki , Suellen Souza da Silva, Auro Régio Rocha Mascarenhas , Carolline Sabino Póvoa , Eduarda Martins Souza , Jonathan Tavares Da Silva , Pedro Henrique Queiroz Dos Santos , Vinicios Batista Monteiro Silva , Maykon Jhuly Martins de Paiva https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Sagratzki , Rebecka Marques GomesSilva, Suellen Souza daMascarenhas , Auro Régio RochaPóvoa , Carolline SabinoSouza , Eduarda MartinsSilva , Jonathan Tavares DaSantos , Pedro Henrique Queiroz DosSilva , Vinicios Batista MonteiroPaiva , Maykon Jhuly Martins de2023-09-13T14:59:24Zoai:ojs.bjihs.emnuvens.com.br:article/501Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2023-09-13T14:59:24Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
THE RISK OF POISONING FROM THE USE OF OZEMPIC (SEMAGLUTIDE) IN NON-DIABETIC PATIENTS EL RIESGO DE ENVENENAMIENTO POR EL USO DE OZEMPIC (SEMAGLUTIDA) EN PACIENTES NO DIABÉTICOS O RISCO DE INTOXICAÇÃO PELO USO DO OZEMPIC (SEMAGLUTIDA) EM PACIENTES NÃO DIABÉTICOS |
title |
THE RISK OF POISONING FROM THE USE OF OZEMPIC (SEMAGLUTIDE) IN NON-DIABETIC PATIENTS |
spellingShingle |
THE RISK OF POISONING FROM THE USE OF OZEMPIC (SEMAGLUTIDE) IN NON-DIABETIC PATIENTS Sagratzki , Rebecka Marques Gomes Ozempic, Semaglutida, diabetes, emagrecimento e intoxicação medicamentosa Ozempic, Semaglutide, diabetes, weight loss and drug intoxication Ozempic, Semaglutida, diabetes, pérdida de peso e intoxicación por fármacos |
title_short |
THE RISK OF POISONING FROM THE USE OF OZEMPIC (SEMAGLUTIDE) IN NON-DIABETIC PATIENTS |
title_full |
THE RISK OF POISONING FROM THE USE OF OZEMPIC (SEMAGLUTIDE) IN NON-DIABETIC PATIENTS |
title_fullStr |
THE RISK OF POISONING FROM THE USE OF OZEMPIC (SEMAGLUTIDE) IN NON-DIABETIC PATIENTS |
title_full_unstemmed |
THE RISK OF POISONING FROM THE USE OF OZEMPIC (SEMAGLUTIDE) IN NON-DIABETIC PATIENTS |
title_sort |
THE RISK OF POISONING FROM THE USE OF OZEMPIC (SEMAGLUTIDE) IN NON-DIABETIC PATIENTS |
author |
Sagratzki , Rebecka Marques Gomes |
author_facet |
Sagratzki , Rebecka Marques Gomes Silva, Suellen Souza da Mascarenhas , Auro Régio Rocha Póvoa , Carolline Sabino Souza , Eduarda Martins Silva , Jonathan Tavares Da Santos , Pedro Henrique Queiroz Dos Silva , Vinicios Batista Monteiro Paiva , Maykon Jhuly Martins de |
author_role |
author |
author2 |
Silva, Suellen Souza da Mascarenhas , Auro Régio Rocha Póvoa , Carolline Sabino Souza , Eduarda Martins Silva , Jonathan Tavares Da Santos , Pedro Henrique Queiroz Dos Silva , Vinicios Batista Monteiro Paiva , Maykon Jhuly Martins de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Sagratzki , Rebecka Marques Gomes Silva, Suellen Souza da Mascarenhas , Auro Régio Rocha Póvoa , Carolline Sabino Souza , Eduarda Martins Silva , Jonathan Tavares Da Santos , Pedro Henrique Queiroz Dos Silva , Vinicios Batista Monteiro Paiva , Maykon Jhuly Martins de |
dc.subject.por.fl_str_mv |
Ozempic, Semaglutida, diabetes, emagrecimento e intoxicação medicamentosa Ozempic, Semaglutide, diabetes, weight loss and drug intoxication Ozempic, Semaglutida, diabetes, pérdida de peso e intoxicación por fármacos |
topic |
Ozempic, Semaglutida, diabetes, emagrecimento e intoxicação medicamentosa Ozempic, Semaglutide, diabetes, weight loss and drug intoxication Ozempic, Semaglutida, diabetes, pérdida de peso e intoxicación por fármacos |
description |
Ozempic (semaglutide), a glucagon-like peptide-1 (GLP-1) receptor agonist originally used in the treatment of type 2 diabetes, has generated interest as a new approach to reducing obesity, as studies point to a high efficacy in reducing systolic blood pressure in obese patients, weight loss and a slight reduction in diastolic blood pressure. The objective of this systematic review was to find out what are the possible adverse effects caused by Semaglutide in patients who do not have DM2, since there are still few studies regarding the toxicity of the drug in non-diabetic patients. According to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines, the databases of the Pubmed and Scielo libraries were systematically used for all studies in this review. Meta-analyses, systematic reviews and randomized clinical trials that addressed the topic between 2012 and 2023 were included. Although the analyzed studies demonstrated efficacy in the use of semaglutide, mainly in non-diabetic obese patients, adverse effects were observed, mainly gastrointestinal, among them there are vomiting, nausea, diarrhea and abdominal pain, mild to moderate, in all analyzed studies, and should be taken into account before using and indicating the drug. It is also necessary for health professionals to follow up more closely and take greater care with patients who already have some type of comorbidity and who may be affected by the adverse effects of the medication. More long-term studies on the use of Ozempic in non-diabetic patients are still needed to be more certain about its toxicity. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/501 10.36557/2674-8169.2023v5n4p1826-1837 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/501 |
identifier_str_mv |
10.36557/2674-8169.2023v5n4p1826-1837 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/501/619 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 5 No. 4 (2023): BJIHS QUALIS B3; 1826-1837 Brazilian Journal of Implantology and Health Sciences ; Vol. 5 Núm. 4 (2023): BJIHS QUALIS B3; 1826-1837 Brazilian Journal of Implantology and Health Sciences ; v. 5 n. 4 (2023): BJIHS QUALIS B3; 1826-1837 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
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1796798438879264768 |