Síntese verde e estabilização de nanopartículas de prata em morinda citrifolia L. (noni) como coadjuvante no tratamento de câncer.

• Autor(a) principal: Morais da Silva , Vitor de
• Data de Publicação: 2024
• Outros Autores: Lizanio, Thalia Macedo, da Conceição, Eduardo Feitosa, Santos, Larissa Nascimento dos, Pereira, Aryna Dias, Rodrigues, Judson Chaves, de Sá, Marcos Vinicios Alves, Silva, Raíssa Gomes da, Araújo da Silva, Tacyane, Vieira, Joseph Gabriel Coutinho, Dos Santos, Deuzuíta
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1706
• topic: Antitumoral; Extrato vegetal; Fitoterápico; Nanopartículas de prata.

Cancer is one of the main public health problems in the world and is among the four leading causes of death in most countries. Silver nanoparticles (AgNPs) are one of the most studied and used nanomaterials due to their characteristic properties and can be used to treat and diagnose cancer. Morinda citrifolia L. (noni) has gained prominence as an important medicinal plant due to its popular use as an antineoplastic and is used for the biosynthesis of metallic nanoparticles. The aim of this research was to synthesize and stabilize AgNPs in noni plant extract by means of green synthesis. AgNPs were synthesized using silver nitrate and sodium citrate, confirming the reduction of silver by the change in color of the nitrate/citrate solution. AgNP characterization was carried out using the ultraviolet-visible (UV-Vis) light spectroscopy method, showing an absorbance band around 400 nm indicating the formation and stabilization of AgNPs. The genotoxic evaluation of the AgNPs was carried out using the Allium cepa test with root germination in 19 bulbs out of the 30 placed in the bioassay. The genotoxicity varied according to the different concentrations, with group A showing a stable mitotic index (MI) and a low chromosome alteration index (CAI); group B with a MI and CAI below group A; C1 with a high MI and CAI also high in relation to group A; C2 with a MI above that found in group A, but a CAI above the values found in groups A, B and C1; C3 with a MI below that found in all groups except B and a CAI above that found in group A and below that found in subgroups C1 and C2, revealing a medium degree of genotoxicity of AgNPs at a concentration of 50%. This study showed that AgNPs stabilized in noni extract showed average genotoxicity, showing promise in the production of a phytotherapeutic adjuvant in the treatment of cancer.