RELATIONSHIP BETWEEN MOOD DISORDERS AND THYROID CHANGES

Detalhes bibliográficos
Autor(a) principal: Bernardes , Bernardo Machado
Data de Publicação: 2024
Outros Autores: Borba , Maisa Cristine de Oliveira, Moreira , Stephanie, Sartori , Carolina Silva, Júnior, Itamar Francisco da Silva, Souza, Marco Tulio Lopes de, Câmara , Ana Claudia Bertol, Bastos , Wanghelys Leyzer, Silveira, Lucas Gonçalves, Rezende , João Matheus Elias, Folgosi , Fernanda, Franzoni, Isabella, Berquo, Juliana Mendes, Moreira, Anna karla Lorrane Guimarães
Tipo de documento: Artigo
Idioma: por
Título da fonte: Brazilian Journal of Implantology and Health Sciences
Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1561
Resumo: The thyroid gland, located at the base of the neck, produces hormones that regulate the body's metabolism, growth and development. Changes in the levels of these hormones, such as hypothyroidism (low production) and hyperthyroidism (high production), can have a significant impact on mental health, influencing the development of mood disorders. Studies demonstrate a strong association between thyroid dysfunction and disorders such as depression and bipolar disorder. In hypothyroidism, depressive symptoms may include fatigue, mental sluggishness, anhedonia, and weight gain. In hyperthyroidism, anxiety, insomnia and irritability are more frequent. The bidirectional relationship between thyroid and mood is complex and involves several mechanisms. Changes in thyroid hormone levels can affect brain neurotransmission, especially serotonin and dopamine, neurotransmitters directly related to mood. Furthermore, the hypothalamic-pituitary-thyroid axis, responsible for thyroid hormonal regulation, can also be influenced by psychological factors such as stress. Objective: To carry out a systematic review of the literature to evaluate the relationship between mood disorders and thyroid changes, investigating the prevalence of mood disorders in individuals with thyroid diseases, the underlying pathophysiological mechanisms and the impact of hormone replacement on mental health. Methodology: The review followed the PRISMA checklist guidelines. The PubMed, Scielo and Web of Science databases were searched using the following descriptors: "mood disorders", "hypothyroidism", "hyperthyroidism", "thyroid" and "mental health". Articles published in the last 10 years were selected. Inclusion criteria: studies that evaluate the relationship between mood disorders and thyroid diseases; Human studies; Published in Portuguese, English or Spanish; Published in the last 10 years. Exclusion: Animal studies; Studies with inadequate methodological designs; Studies that do not evaluate the relationship between mood and thyroid. Results: 15 studies were selected. The review identified that the prevalence of mood disorders is significantly higher in individuals with thyroid disease than in the general population. Hypothyroidism is associated with depression, while hyperthyroidism is more related to anxiety. The pathophysiological mechanisms underlying the relationship between mood and thyroid are complex and involve changes in cerebral neurotransmission, the hypothalamic-pituitary-thyroid axis and the response to stress. Adequate hormone replacement for thyroid disease can significantly improve symptoms of mood disorders in many cases. Conclusions: The systematic review confirmed the strong association between mood disorders and thyroid changes. Thyroid dysfunction can be a risk factor for the development of mood disorders, and adequate hormone replacement can be an important therapeutic tool.
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spelling RELATIONSHIP BETWEEN MOOD DISORDERS AND THYROID CHANGES RELATIONSHIP BETWEEN MOOD DISORDERS AND THYROID CHANGESThe thyroid gland, located at the base of the neck, produces hormones that regulate the body's metabolism, growth and development. Changes in the levels of these hormones, such as hypothyroidism (low production) and hyperthyroidism (high production), can have a significant impact on mental health, influencing the development of mood disorders. Studies demonstrate a strong association between thyroid dysfunction and disorders such as depression and bipolar disorder. In hypothyroidism, depressive symptoms may include fatigue, mental sluggishness, anhedonia, and weight gain. In hyperthyroidism, anxiety, insomnia and irritability are more frequent. The bidirectional relationship between thyroid and mood is complex and involves several mechanisms. Changes in thyroid hormone levels can affect brain neurotransmission, especially serotonin and dopamine, neurotransmitters directly related to mood. Furthermore, the hypothalamic-pituitary-thyroid axis, responsible for thyroid hormonal regulation, can also be influenced by psychological factors such as stress. Objective: To carry out a systematic review of the literature to evaluate the relationship between mood disorders and thyroid changes, investigating the prevalence of mood disorders in individuals with thyroid diseases, the underlying pathophysiological mechanisms and the impact of hormone replacement on mental health. Methodology: The review followed the PRISMA checklist guidelines. The PubMed, Scielo and Web of Science databases were searched using the following descriptors: "mood disorders", "hypothyroidism", "hyperthyroidism", "thyroid" and "mental health". Articles published in the last 10 years were selected. Inclusion criteria: studies that evaluate the relationship between mood disorders and thyroid diseases; Human studies; Published in Portuguese, English or Spanish; Published in the last 10 years. Exclusion: Animal studies; Studies with inadequate methodological designs; Studies that do not evaluate the relationship between mood and thyroid. Results: 15 studies were selected. The review identified that the prevalence of mood disorders is significantly higher in individuals with thyroid disease than in the general population. Hypothyroidism is associated with depression, while hyperthyroidism is more related to anxiety. The pathophysiological mechanisms underlying the relationship between mood and thyroid are complex and involve changes in cerebral neurotransmission, the hypothalamic-pituitary-thyroid axis and the response to stress. Adequate hormone replacement for thyroid disease can significantly improve symptoms of mood disorders in many cases. Conclusions: The systematic review confirmed the strong association between mood disorders and thyroid changes. Thyroid dysfunction can be a risk factor for the development of mood disorders, and adequate hormone replacement can be an important therapeutic tool.The thyroid gland, located at the base of the neck, produces hormones that regulate the body's metabolism, growth and development. Changes in the levels of these hormones, such as hypothyroidism (low production) and hyperthyroidism (high production), can have a significant impact on mental health, influencing the development of mood disorders. Studies demonstrate a strong association between thyroid dysfunction and disorders such as depression and bipolar disorder. In hypothyroidism, depressive symptoms may include fatigue, mental sluggishness, anhedonia, and weight gain. In hyperthyroidism, anxiety, insomnia and irritability are more frequent. The bidirectional relationship between thyroid and mood is complex and involves several mechanisms. Changes in thyroid hormone levels can affect brain neurotransmission, especially serotonin and dopamine, neurotransmitters directly related to mood. Furthermore, the hypothalamic-pituitary-thyroid axis, responsible for thyroid hormonal regulation, can also be influenced by psychological factors such as stress. Objective: To carry out a systematic review of the literature to evaluate the relationship between mood disorders and thyroid changes, investigating the prevalence of mood disorders in individuals with thyroid diseases, the underlying pathophysiological mechanisms and the impact of hormone replacement on mental health. Methodology: The review followed the PRISMA checklist guidelines. The PubMed, Scielo and Web of Science databases were searched using the following descriptors: "mood disorders", "hypothyroidism", "hyperthyroidism", "thyroid" and "mental health". Articles published in the last 10 years were selected. Inclusion criteria: studies that evaluate the relationship between mood disorders and thyroid diseases; Human studies; Published in Portuguese, English or Spanish; Published in the last 10 years. Exclusion: Animal studies; Studies with inadequate methodological designs; Studies that do not evaluate the relationship between mood and thyroid. Results: 15 studies were selected. The review identified that the prevalence of mood disorders is significantly higher in individuals with thyroid disease than in the general population. Hypothyroidism is associated with depression, while hyperthyroidism is more related to anxiety. The pathophysiological mechanisms underlying the relationship between mood and thyroid are complex and involve changes in cerebral neurotransmission, the hypothalamic-pituitary-thyroid axis and the response to stress. Adequate hormone replacement for thyroid disease can significantly improve symptoms of mood disorders in many cases. Conclusions: The systematic review confirmed the strong association between mood disorders and thyroid changes. Thyroid dysfunction can be a risk factor for the development of mood disorders, and adequate hormone replacement can be an important therapeutic tool.Specialized Dentistry Group2024-02-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/156110.36557/2674-8169.2024v6n2p2241-2256Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 2 (2024): BJIHS QUALIS B3; 2241-2256Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 2 (2024): BJIHS QUALIS B3; 2241-2256Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 2 (2024): BJIHS QUALIS B3; 2241-22562674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/1561/1739Copyright (c) 2024 Bernardo Machado Bernardes , Maisa Cristine de Oliveira Borba , Stephanie Moreira , Carolina Silva Sartori , Itamar Francisco da Silva Júnior, Marco Tulio Lopes de Souza, Ana Claudia Bertol Câmara , Wanghelys Leyzer Bastos , Lucas Gonçalves Silveira, João Matheus Elias Rezende , Fernanda Folgosi , Isabella Franzoni, Juliana Mendes Berquo, Anna karla Lorrane Guimarães Moreirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBernardes , Bernardo MachadoBorba , Maisa Cristine de OliveiraMoreira , StephanieSartori , Carolina Silva Júnior, Itamar Francisco da SilvaSouza, Marco Tulio Lopes de Câmara , Ana Claudia BertolBastos , Wanghelys LeyzerSilveira, Lucas GonçalvesRezende , João Matheus EliasFolgosi , FernandaFranzoni, IsabellaBerquo, Juliana MendesMoreira, Anna karla Lorrane Guimarães2024-02-27T22:35:31Zoai:ojs.bjihs.emnuvens.com.br:article/1561Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2024-02-27T22:35:31Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false
dc.title.none.fl_str_mv RELATIONSHIP BETWEEN MOOD DISORDERS AND THYROID CHANGES
RELATIONSHIP BETWEEN MOOD DISORDERS AND THYROID CHANGES
title RELATIONSHIP BETWEEN MOOD DISORDERS AND THYROID CHANGES
spellingShingle RELATIONSHIP BETWEEN MOOD DISORDERS AND THYROID CHANGES
Bernardes , Bernardo Machado
title_short RELATIONSHIP BETWEEN MOOD DISORDERS AND THYROID CHANGES
title_full RELATIONSHIP BETWEEN MOOD DISORDERS AND THYROID CHANGES
title_fullStr RELATIONSHIP BETWEEN MOOD DISORDERS AND THYROID CHANGES
title_full_unstemmed RELATIONSHIP BETWEEN MOOD DISORDERS AND THYROID CHANGES
title_sort RELATIONSHIP BETWEEN MOOD DISORDERS AND THYROID CHANGES
author Bernardes , Bernardo Machado
author_facet Bernardes , Bernardo Machado
Borba , Maisa Cristine de Oliveira
Moreira , Stephanie
Sartori , Carolina Silva
Júnior, Itamar Francisco da Silva
Souza, Marco Tulio Lopes de
Câmara , Ana Claudia Bertol
Bastos , Wanghelys Leyzer
Silveira, Lucas Gonçalves
Rezende , João Matheus Elias
Folgosi , Fernanda
Franzoni, Isabella
Berquo, Juliana Mendes
Moreira, Anna karla Lorrane Guimarães
author_role author
author2 Borba , Maisa Cristine de Oliveira
Moreira , Stephanie
Sartori , Carolina Silva
Júnior, Itamar Francisco da Silva
Souza, Marco Tulio Lopes de
Câmara , Ana Claudia Bertol
Bastos , Wanghelys Leyzer
Silveira, Lucas Gonçalves
Rezende , João Matheus Elias
Folgosi , Fernanda
Franzoni, Isabella
Berquo, Juliana Mendes
Moreira, Anna karla Lorrane Guimarães
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bernardes , Bernardo Machado
Borba , Maisa Cristine de Oliveira
Moreira , Stephanie
Sartori , Carolina Silva
Júnior, Itamar Francisco da Silva
Souza, Marco Tulio Lopes de
Câmara , Ana Claudia Bertol
Bastos , Wanghelys Leyzer
Silveira, Lucas Gonçalves
Rezende , João Matheus Elias
Folgosi , Fernanda
Franzoni, Isabella
Berquo, Juliana Mendes
Moreira, Anna karla Lorrane Guimarães
description The thyroid gland, located at the base of the neck, produces hormones that regulate the body's metabolism, growth and development. Changes in the levels of these hormones, such as hypothyroidism (low production) and hyperthyroidism (high production), can have a significant impact on mental health, influencing the development of mood disorders. Studies demonstrate a strong association between thyroid dysfunction and disorders such as depression and bipolar disorder. In hypothyroidism, depressive symptoms may include fatigue, mental sluggishness, anhedonia, and weight gain. In hyperthyroidism, anxiety, insomnia and irritability are more frequent. The bidirectional relationship between thyroid and mood is complex and involves several mechanisms. Changes in thyroid hormone levels can affect brain neurotransmission, especially serotonin and dopamine, neurotransmitters directly related to mood. Furthermore, the hypothalamic-pituitary-thyroid axis, responsible for thyroid hormonal regulation, can also be influenced by psychological factors such as stress. Objective: To carry out a systematic review of the literature to evaluate the relationship between mood disorders and thyroid changes, investigating the prevalence of mood disorders in individuals with thyroid diseases, the underlying pathophysiological mechanisms and the impact of hormone replacement on mental health. Methodology: The review followed the PRISMA checklist guidelines. The PubMed, Scielo and Web of Science databases were searched using the following descriptors: "mood disorders", "hypothyroidism", "hyperthyroidism", "thyroid" and "mental health". Articles published in the last 10 years were selected. Inclusion criteria: studies that evaluate the relationship between mood disorders and thyroid diseases; Human studies; Published in Portuguese, English or Spanish; Published in the last 10 years. Exclusion: Animal studies; Studies with inadequate methodological designs; Studies that do not evaluate the relationship between mood and thyroid. Results: 15 studies were selected. The review identified that the prevalence of mood disorders is significantly higher in individuals with thyroid disease than in the general population. Hypothyroidism is associated with depression, while hyperthyroidism is more related to anxiety. The pathophysiological mechanisms underlying the relationship between mood and thyroid are complex and involve changes in cerebral neurotransmission, the hypothalamic-pituitary-thyroid axis and the response to stress. Adequate hormone replacement for thyroid disease can significantly improve symptoms of mood disorders in many cases. Conclusions: The systematic review confirmed the strong association between mood disorders and thyroid changes. Thyroid dysfunction can be a risk factor for the development of mood disorders, and adequate hormone replacement can be an important therapeutic tool.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv https://bjihs.emnuvens.com.br/bjihs/article/view/1561
10.36557/2674-8169.2024v6n2p2241-2256
url https://bjihs.emnuvens.com.br/bjihs/article/view/1561
identifier_str_mv 10.36557/2674-8169.2024v6n2p2241-2256
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://bjihs.emnuvens.com.br/bjihs/article/view/1561/1739
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info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Specialized Dentistry Group
publisher.none.fl_str_mv Specialized Dentistry Group
dc.source.none.fl_str_mv Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 2 (2024): BJIHS QUALIS B3; 2241-2256
Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 2 (2024): BJIHS QUALIS B3; 2241-2256
Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 2 (2024): BJIHS QUALIS B3; 2241-2256
2674-8169
reponame:Brazilian Journal of Implantology and Health Sciences
instname:Grupo de Odontologia Especializada (GOE)
instacron:GOE
instname_str Grupo de Odontologia Especializada (GOE)
instacron_str GOE
institution GOE
reponame_str Brazilian Journal of Implantology and Health Sciences
collection Brazilian Journal of Implantology and Health Sciences
repository.name.fl_str_mv Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)
repository.mail.fl_str_mv journal.bjihs@periodicosbrasil.com.br
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