Development of Novel Therapies for Glaucoma Treatment: An Integrative Analysis

• Autor(a) principal: Nascimento Arçari, Cibely
• Data de Publicação: 2024
• Outros Autores: Nascimento Arçari , Jordana
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1336
• topic: Glaucoma; Terapias Inovadoras; Abordagem Multidisciplinar.; Glaucoma; Innovative Therapies; Multidisciplinary Approach.

This study examines promising strategies in the development of new therapies for the treatment of glaucoma, adopting an integrative and innovative perspective. Initially, advances in pharmacological therapies are highlighted, focusing on potential neuroprotective agents and specific modulators that have demonstrated efficacy in preserving ocular function and reducing disease progression. Beyond pharmacological approaches, the analysis extends to consider interventions exploring the underlying mechanisms of glaucoma. The identification of molecular targets and emerging biological pathways emphasizes the importance of understanding the pathophysiology of the disease for the development of more targeted therapies. Another notable point addresses complementary therapies, such as optimizing drug delivery strategies to improve effectiveness and reduce adverse effects. The analysis includes discussions on extended-release systems, innovative formulations, and minimally invasive surgical approaches, representing significant advancements in the quest for more effective and tolerable treatments. Simultaneously, therapies aiming not only at reducing intraocular pressure but also at preserving and regenerating damaged ocular tissue are considered. This involves the exploration of regenerative approaches, such as cellular therapies and growth factors, highlighting their promising contribution to the restoration of ocular health. In addition to therapeutic innovations, this work underscores the need for a comprehensive understanding of glaucoma, including genetic, metabolic, and environmental factors influencing individual responses to proposed therapies. Emphasizing the personalization of interventions highlights the complexity of the disease and the importance of considering individual patient characteristics. In conclusion, the study emphasizes the importance of a multidisciplinary approach, integrating different therapeutic modalities to optimize outcomes in glaucoma treatment. The combination of innovative pharmacological approaches, advanced delivery strategies, and regenerative therapies emerges as a promising perspective to comprehensively and effectively address this ophthalmologic challenge.