COMPARISON OF SEDATION STRATEGIES IN PATIENTS UNDER MECHANICAL VENTILATION

• Autor(a) principal: Kundsin , Alana
• Data de Publicação: 2024
• Outros Autores: Paula , Alex Blank de, Spiguel , Larissa Claro, Cardoso , Renan Sesquim
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1511
• topic: Sedativos; Unidade de Terapia Intensiva; Ventilação Mecânica.; Sedatives; Intensive Care Unit; Mechanical Ventilation.

 The importance of conducting comparisons between sedatives in an Intensive Care Unit (ICU) lies in the need to identify the most effective and safe sedative agent, aiming to enhance the comfort and safety of patients. This article is an integrative literature review, of a descriptive nature, relying on materials freely and fully available on Scielo and PubMed databases from 2020 to 2024. Six articles directly related to the theme and chosen methodology were selected. The objective of this study was to identify and compare the main sedation strategies in critically ill patients. The research question, according to the PICO strategy, was: in mechanically ventilated patients in the ICU, what is the comparative efficacy of different sedation strategies in reducing mechanical ventilation time and the occurrence of adverse events? It was concluded that ciprofol is comparable to propofol in terms of good tolerance and efficacy for sedation. Dexmedetomidine is more effective in reducing mechanical ventilation (MV) time compared to propofol. There are no significant disparities in adverse effects and mechanical ventilation time between remimazolam besylate and propofol. Propofol significantly reduced mechanical ventilation time compared to midazolam. Remimazolam besylate emerges as a potential substitute for propofol and midazolam, with a lower likelihood of causing hemodynamic depression and contamination compared to propofol. The combination of dexmedetomidine with propofol demonstrated the ability to reduce recovery and extubation periods in mechanically ventilated patients.