Steroids in the dental implant osseointegration: literature review.
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/84 |
Resumo: | Osseointegration of dental implants (OID) comprises the direct contact between bone and implant surface. Cyclooxygenase (COX) enzymes are essential in healing and cell regulation during bone repair and remodeling, being important in OID. Considering that non-steroidal anti-inflammatory drugs (NSAIDs) are COX inhibitors and commonly prescribed for relief of undesirable signs and symptoms in the postoperative period in implant dentistry, the present review aimed to study the influence of the use of these drugs in OID. For this purpose, the keywords Dental implantation, bone-implant interface and Anti-inflammatories, combined with each other and in the English language, were used in the Pubmed database. In all, 24 articles were found and, after reading their abstracts, 10 studies of pre-clinical (n = 6) or clinical (n = 4) scientific research were selected, which were read in full. Studies of literature reviews that did not use NSAIDs specifically were excluded. Among the 10 selected manuscripts, 5 studies found that NSAIDs interfere negatively in OID and all of these referred to selective or preferential COX 2 inhibition. Meanwhile, 2 studies found the opposite result, but using non-selective inhibitor NSAIDs and, therefore, of COX 1. The remaining 3 articles reported neutrality in the referred result. Thus, despite the lack of data in the literature, it is suggested that NSAIDs may interfere negatively in OID, especially as a result of COX-2 inhibition and in direct association with the dose of use. |
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Steroids in the dental implant osseointegration: literature review.Steroids in the dental implant osseointegration: literature review.Steroids; Anti-inflammatories; Osseointegration; Dental implants.Steroids; Anti-inflammatories; Osseointegration; Dental implants.Osseointegration of dental implants (OID) comprises the direct contact between bone and implant surface. Cyclooxygenase (COX) enzymes are essential in healing and cell regulation during bone repair and remodeling, being important in OID. Considering that non-steroidal anti-inflammatory drugs (NSAIDs) are COX inhibitors and commonly prescribed for relief of undesirable signs and symptoms in the postoperative period in implant dentistry, the present review aimed to study the influence of the use of these drugs in OID. For this purpose, the keywords Dental implantation, bone-implant interface and Anti-inflammatories, combined with each other and in the English language, were used in the Pubmed database. In all, 24 articles were found and, after reading their abstracts, 10 studies of pre-clinical (n = 6) or clinical (n = 4) scientific research were selected, which were read in full. Studies of literature reviews that did not use NSAIDs specifically were excluded. Among the 10 selected manuscripts, 5 studies found that NSAIDs interfere negatively in OID and all of these referred to selective or preferential COX 2 inhibition. Meanwhile, 2 studies found the opposite result, but using non-selective inhibitor NSAIDs and, therefore, of COX 1. The remaining 3 articles reported neutrality in the referred result. Thus, despite the lack of data in the literature, it is suggested that NSAIDs may interfere negatively in OID, especially as a result of COX-2 inhibition and in direct association with the dose of use.Osseointegration of dental implants (OID) comprises the direct contact between bone and implant surface. Cyclooxygenase (COX) enzymes are essential in healing and cell regulation during bone repair and remodeling, being important in OID. Considering that non-steroidal anti-inflammatory drugs (NSAIDs) are COX inhibitors and commonly prescribed for relief of undesirable signs and symptoms in the postoperative period in implant dentistry, the present review aimed to study the influence of the use of these drugs in OID. For this purpose, the keywords Dental implantation, bone-implant interface and Anti-inflammatories, combined with each other and in the English language, were used in the Pubmed database. In all, 24 articles were found and, after reading their abstracts, 10 studies of pre-clinical (n = 6) or clinical (n = 4) scientific research were selected, which were read in full. Studies of literature reviews that did not use NSAIDs specifically were excluded. Among the 10 selected manuscripts, 5 studies found that NSAIDs interfere negatively in OID and all of these referred to selective or preferential COX 2 inhibition. Meanwhile, 2 studies found the opposite result, but using non-selective inhibitor NSAIDs and, therefore, of COX 1. The remaining 3 articles reported neutrality in the referred result. Thus, despite the lack of data in the literature, it is suggested that NSAIDs may interfere negatively in OID, especially as a result of COX-2 inhibition and in direct association with the dose of use.Specialized Dentistry Group2020-07-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/84Brazilian Journal of Implantology and Health Sciences ; Vol. 2 No. 7 (2020): July; 04-06Brazilian Journal of Implantology and Health Sciences ; Vol. 2 Núm. 7 (2020): Julho; 04-06Brazilian Journal of Implantology and Health Sciences ; v. 2 n. 7 (2020): Julho; 04-062674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEenghttps://bjihs.emnuvens.com.br/bjihs/article/view/84/124Copyright (c) 2020 André Gaspar Neto, Maria Luiza Mascarenhasinfo:eu-repo/semantics/openAccessNeto, André Gaspar Mascarenhas, Maria Luiza2020-07-16T09:02:41Zoai:ojs.bjihs.emnuvens.com.br:article/84Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2020-07-16T09:02:41Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
Steroids in the dental implant osseointegration: literature review. Steroids in the dental implant osseointegration: literature review. |
title |
Steroids in the dental implant osseointegration: literature review. |
spellingShingle |
Steroids in the dental implant osseointegration: literature review. Neto, André Gaspar Steroids; Anti-inflammatories; Osseointegration; Dental implants. Steroids; Anti-inflammatories; Osseointegration; Dental implants. |
title_short |
Steroids in the dental implant osseointegration: literature review. |
title_full |
Steroids in the dental implant osseointegration: literature review. |
title_fullStr |
Steroids in the dental implant osseointegration: literature review. |
title_full_unstemmed |
Steroids in the dental implant osseointegration: literature review. |
title_sort |
Steroids in the dental implant osseointegration: literature review. |
author |
Neto, André Gaspar |
author_facet |
Neto, André Gaspar Mascarenhas, Maria Luiza |
author_role |
author |
author2 |
Mascarenhas, Maria Luiza |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Neto, André Gaspar Mascarenhas, Maria Luiza |
dc.subject.por.fl_str_mv |
Steroids; Anti-inflammatories; Osseointegration; Dental implants. Steroids; Anti-inflammatories; Osseointegration; Dental implants. |
topic |
Steroids; Anti-inflammatories; Osseointegration; Dental implants. Steroids; Anti-inflammatories; Osseointegration; Dental implants. |
description |
Osseointegration of dental implants (OID) comprises the direct contact between bone and implant surface. Cyclooxygenase (COX) enzymes are essential in healing and cell regulation during bone repair and remodeling, being important in OID. Considering that non-steroidal anti-inflammatory drugs (NSAIDs) are COX inhibitors and commonly prescribed for relief of undesirable signs and symptoms in the postoperative period in implant dentistry, the present review aimed to study the influence of the use of these drugs in OID. For this purpose, the keywords Dental implantation, bone-implant interface and Anti-inflammatories, combined with each other and in the English language, were used in the Pubmed database. In all, 24 articles were found and, after reading their abstracts, 10 studies of pre-clinical (n = 6) or clinical (n = 4) scientific research were selected, which were read in full. Studies of literature reviews that did not use NSAIDs specifically were excluded. Among the 10 selected manuscripts, 5 studies found that NSAIDs interfere negatively in OID and all of these referred to selective or preferential COX 2 inhibition. Meanwhile, 2 studies found the opposite result, but using non-selective inhibitor NSAIDs and, therefore, of COX 1. The remaining 3 articles reported neutrality in the referred result. Thus, despite the lack of data in the literature, it is suggested that NSAIDs may interfere negatively in OID, especially as a result of COX-2 inhibition and in direct association with the dose of use. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-07-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/84 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/84 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/84/124 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 André Gaspar Neto, Maria Luiza Mascarenhas info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 André Gaspar Neto, Maria Luiza Mascarenhas |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 2 No. 7 (2020): July; 04-06 Brazilian Journal of Implantology and Health Sciences ; Vol. 2 Núm. 7 (2020): Julho; 04-06 Brazilian Journal of Implantology and Health Sciences ; v. 2 n. 7 (2020): Julho; 04-06 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
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1796798447833055232 |