Perspectivas Atuais sobre Terapias para a Doença de Alzheimer: Uma Análise da Literatura Contemporânea

• Autor(a) principal: Pereira Levada, Leonardo
• Data de Publicação: 2024
• Outros Autores: Campos de Paiva, Gabriela, de Melo Rocha, Laura, Lucas Carneiro Ramos, Pedro, Carlos Luzio Filho, Antonio, Caroline Bennes Martelet Simões, Jeniffer, Tino Barbosa Ferreira, Isabella, Priscila Bezerra de Souza, Alexia, Santos Arruda, Luma, Felipe Martins Luzio, Luis, Roberto Fuzari Silva, João, Sobral Dias , Jennifer, Filipe Modesto Ribeiro Cruz, André, Rafaela Gomes Taneda, Bruna, Siqueira leão, Victoria
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1597
• topic: Alzheimer; Tratamento; Neurologia; estratégias terapêuticas

The article provides a comprehensive review of current and emerging therapeutic strategies for the treatment of Alzheimer's disease (AD), an increasingly prevalent neurodegenerative condition in the elderly. The multifaceted complexity of treatment is highlighted, encompassing both pharmacological and non-pharmacological approaches. Acetylcholinesterase inhibitors are commonly used to improve cholinergic neurotransmission, while immunotherapy, including vaccines against beta-amyloid, is in clinical trial phase. Additionally, potential treatments such as antidiabetic agents, serotonergic psychedelics, and gene therapy are discussed. Inflammation is recognized as a crucial component in the pathogenesis of AD, and anti-inflammatory agents show promise in reducing neuroinflammation. However, challenges persist, such as validating results in humans, the lack of reliable biomarkers for early diagnosis, and the need to find effective therapeutic targets that can modify the disease's progression.