Perspectivas Atuais e Futuras nas Abordagens Terapêuticas para Hipertensão Pulmonar Persistente Neonatal.
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/669 |
Resumo: | Persistent Pulmonary Hypertension of the Newborn (PPHN) is a complex condition that represents a significant challenge in neonatology. This study reviews current therapeutic approaches for PPHN, with a focus on the efficacy and safety of sildenafil, an emerging and promising therapeutic option. An integrative review was carried out, covering articles, theses and dissertations available on scientific databases, considering the references indicated in Vancouver. Analysis of the sources included evaluation of relevance, methodology and results. Among the sources analyzed, studies such as Margotto et al. (2006), Miranda et al. (2014), and Yaseen et al. (2012) explored the efficacy of sildenafil in different clinical contexts. Carvalho et al. (2005) and Ferreira et al. (2018) highlighted the importance of correct diagnosis and the role of sildenafil in associated conditions. Rodrigues et al. (2008) and Magalhães et al. (2011) offered perspectives on etiopathogenesis and various therapeutic approaches. Sildenafil has emerged as a promising therapeutic alternative for NRHP, although more robust clinical studies are needed to validate its efficacy and safety in different clinical contexts. The ideal therapeutic approach should be individualized, taking into account the severity of the condition and other comorbidities. Interdisciplinary collaboration is vital to optimize the management of PPROM and improve outcomes for affected neonates. |
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Brazilian Journal of Implantology and Health Sciences |
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Perspectivas Atuais e Futuras nas Abordagens Terapêuticas para Hipertensão Pulmonar Persistente Neonatal.Hipertensão PulmonarRecém-nascidoNeonatologiaTratamento FarmacológicoDiagnóstico PrecoceUnidades de Terapia Intensiva NeonatalPersistent Pulmonary Hypertension of the Newborn (PPHN) is a complex condition that represents a significant challenge in neonatology. This study reviews current therapeutic approaches for PPHN, with a focus on the efficacy and safety of sildenafil, an emerging and promising therapeutic option. An integrative review was carried out, covering articles, theses and dissertations available on scientific databases, considering the references indicated in Vancouver. Analysis of the sources included evaluation of relevance, methodology and results. Among the sources analyzed, studies such as Margotto et al. (2006), Miranda et al. (2014), and Yaseen et al. (2012) explored the efficacy of sildenafil in different clinical contexts. Carvalho et al. (2005) and Ferreira et al. (2018) highlighted the importance of correct diagnosis and the role of sildenafil in associated conditions. Rodrigues et al. (2008) and Magalhães et al. (2011) offered perspectives on etiopathogenesis and various therapeutic approaches. Sildenafil has emerged as a promising therapeutic alternative for NRHP, although more robust clinical studies are needed to validate its efficacy and safety in different clinical contexts. The ideal therapeutic approach should be individualized, taking into account the severity of the condition and other comorbidities. Interdisciplinary collaboration is vital to optimize the management of PPROM and improve outcomes for affected neonates.A Hipertensão Pulmonar Persistente do Recém-Nascido (HPPRN) é uma condição complexa que representa um desafio significativo na neonatologia. Este estudo revisa abordagens terapêuticas atuais para HPPRN, com enfoque na eficácia e segurança do sildenafil, uma opção terapêutica emergente e promissora. Realizou-se uma revisão integrativa, abrangendo artigos, teses e dissertações disponíveis em bases científicas, considerando as referências indicadas em Vancouver. A análise das fontes incluiu avaliação de relevância, metodologia e resultados. Dentre as fontes analisadas, estudos como Margotto et al. (2006), Miranda et al. (2014), e Yaseen et al. (2012) exploraram a eficácia do sildenafil em diferentes contextos clínicos. Carvalho et al. (2005) e Ferreira et al. (2018) destacaram a importância do diagnóstico correto e o papel do sildenafil em condições associadas. Rodrigues et al. (2008) e Magalhães et al. (2011) ofereceram perspectivas sobre a etiopatogenia e variadas abordagens terapêuticas. O sildenafil surge como uma alternativa terapêutica promissora para HPPRN, embora sejam necessários mais estudos clínicos robustos para validar sua eficácia e segurança em diferentes contextos clínicos. A abordagem terapêutica ideal deve ser individualizada, levando em consideração a gravidade da condição e outras comorbidades. A colaboração interdisciplinar é vital para otimizar a gestão da HPPRN e melhorar os resultados para os neonatos afetados. Specialized Dentistry Group2023-10-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/66910.36557/2674-8169.2023v5n5p946-955Brazilian Journal of Implantology and Health Sciences ; Vol. 5 No. 5 (2023): BJIHS QUALIS B3; 946-955Brazilian Journal of Implantology and Health Sciences ; Vol. 5 Núm. 5 (2023): BJIHS QUALIS B3; 946-955Brazilian Journal of Implantology and Health Sciences ; v. 5 n. 5 (2023): BJIHS QUALIS B3; 946-9552674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/669/808Copyright (c) 2023 Alexandre Molina Loureiro , Arthur Del Puppo Pontes, Caetano Zorthêa Ballester, Gabriel Giordano Siqueira e Teixeira, Leonardo Silva Homem, Lívia Callegari Albernaz , Marcella Scorsatto Dreher, Pedro Henrique Rangel Boffy , Pedro Miranda Abaurre Silveira , Rafael Maia Santoshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMolina Loureiro , AlexandreDel Puppo Pontes, ArthurZorthêa Ballester, CaetanoSiqueira e Teixeira, Gabriel GiordanoSilva Homem, LeonardoCallegari Albernaz , LíviaScorsatto Dreher, MarcellaRangel Boffy , Pedro Henrique Miranda Abaurre Silveira , PedroMaia Santos, Rafael2023-10-13T14:44:32Zoai:ojs.bjihs.emnuvens.com.br:article/669Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2023-10-13T14:44:32Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
Perspectivas Atuais e Futuras nas Abordagens Terapêuticas para Hipertensão Pulmonar Persistente Neonatal. |
title |
Perspectivas Atuais e Futuras nas Abordagens Terapêuticas para Hipertensão Pulmonar Persistente Neonatal. |
spellingShingle |
Perspectivas Atuais e Futuras nas Abordagens Terapêuticas para Hipertensão Pulmonar Persistente Neonatal. Molina Loureiro , Alexandre Hipertensão Pulmonar Recém-nascido Neonatologia Tratamento Farmacológico Diagnóstico Precoce Unidades de Terapia Intensiva Neonatal |
title_short |
Perspectivas Atuais e Futuras nas Abordagens Terapêuticas para Hipertensão Pulmonar Persistente Neonatal. |
title_full |
Perspectivas Atuais e Futuras nas Abordagens Terapêuticas para Hipertensão Pulmonar Persistente Neonatal. |
title_fullStr |
Perspectivas Atuais e Futuras nas Abordagens Terapêuticas para Hipertensão Pulmonar Persistente Neonatal. |
title_full_unstemmed |
Perspectivas Atuais e Futuras nas Abordagens Terapêuticas para Hipertensão Pulmonar Persistente Neonatal. |
title_sort |
Perspectivas Atuais e Futuras nas Abordagens Terapêuticas para Hipertensão Pulmonar Persistente Neonatal. |
author |
Molina Loureiro , Alexandre |
author_facet |
Molina Loureiro , Alexandre Del Puppo Pontes, Arthur Zorthêa Ballester, Caetano Siqueira e Teixeira, Gabriel Giordano Silva Homem, Leonardo Callegari Albernaz , Lívia Scorsatto Dreher, Marcella Rangel Boffy , Pedro Henrique Miranda Abaurre Silveira , Pedro Maia Santos, Rafael |
author_role |
author |
author2 |
Del Puppo Pontes, Arthur Zorthêa Ballester, Caetano Siqueira e Teixeira, Gabriel Giordano Silva Homem, Leonardo Callegari Albernaz , Lívia Scorsatto Dreher, Marcella Rangel Boffy , Pedro Henrique Miranda Abaurre Silveira , Pedro Maia Santos, Rafael |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Molina Loureiro , Alexandre Del Puppo Pontes, Arthur Zorthêa Ballester, Caetano Siqueira e Teixeira, Gabriel Giordano Silva Homem, Leonardo Callegari Albernaz , Lívia Scorsatto Dreher, Marcella Rangel Boffy , Pedro Henrique Miranda Abaurre Silveira , Pedro Maia Santos, Rafael |
dc.subject.por.fl_str_mv |
Hipertensão Pulmonar Recém-nascido Neonatologia Tratamento Farmacológico Diagnóstico Precoce Unidades de Terapia Intensiva Neonatal |
topic |
Hipertensão Pulmonar Recém-nascido Neonatologia Tratamento Farmacológico Diagnóstico Precoce Unidades de Terapia Intensiva Neonatal |
description |
Persistent Pulmonary Hypertension of the Newborn (PPHN) is a complex condition that represents a significant challenge in neonatology. This study reviews current therapeutic approaches for PPHN, with a focus on the efficacy and safety of sildenafil, an emerging and promising therapeutic option. An integrative review was carried out, covering articles, theses and dissertations available on scientific databases, considering the references indicated in Vancouver. Analysis of the sources included evaluation of relevance, methodology and results. Among the sources analyzed, studies such as Margotto et al. (2006), Miranda et al. (2014), and Yaseen et al. (2012) explored the efficacy of sildenafil in different clinical contexts. Carvalho et al. (2005) and Ferreira et al. (2018) highlighted the importance of correct diagnosis and the role of sildenafil in associated conditions. Rodrigues et al. (2008) and Magalhães et al. (2011) offered perspectives on etiopathogenesis and various therapeutic approaches. Sildenafil has emerged as a promising therapeutic alternative for NRHP, although more robust clinical studies are needed to validate its efficacy and safety in different clinical contexts. The ideal therapeutic approach should be individualized, taking into account the severity of the condition and other comorbidities. Interdisciplinary collaboration is vital to optimize the management of PPROM and improve outcomes for affected neonates. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-10-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/669 10.36557/2674-8169.2023v5n5p946-955 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/669 |
identifier_str_mv |
10.36557/2674-8169.2023v5n5p946-955 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/669/808 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 5 No. 5 (2023): BJIHS QUALIS B3; 946-955 Brazilian Journal of Implantology and Health Sciences ; Vol. 5 Núm. 5 (2023): BJIHS QUALIS B3; 946-955 Brazilian Journal of Implantology and Health Sciences ; v. 5 n. 5 (2023): BJIHS QUALIS B3; 946-955 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
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1796798440072544256 |