Restless legs syndrome: pathophysiological and therapeutic bases
Autor(a) principal: | |
---|---|
Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/1798 |
Resumo: | Introduction: Restless Legs Syndrome (RLS), also known as Willis-Ekbom Disease, is a chronic neurological disorder characterized by unpleasant and irresistible sensations in the legs, usually during periods of rest or inactivity, which result in an uncontrollable desire to move the affected members. Objective: To evaluate the pathophysiological and therapeutic bases associated with restless legs syndrome. Methodology: This is a bibliographic review that included original articles and systematic reviews in English and Portuguese, which addressed pathophysiological aspects and management of SIP, published between 2014 and 2024, selected from the PubMed, Scopus and SciELO databases. After careful selection, 19 articles were chosen to compose this bibliographic review. Results: The condition presents a broad pathophysiological pattern, with several relevant aspects, including genetic characteristics, such as the dominant pattern and interaction at specific loci. In addition to environmental aspects, such as dysregulation of the dopaminergic system, which corroborates the symptomatology of the condition, as well as peripheral and cerebral iron deficit, which is considered a key biological factor in RLS. The management of RLS is diverse and involves non-pharmacological interventions, such as massage and walking, which can complement drug therapy. The choice of pharmacological treatment is individualized and uses dopaminergic agonists, alpha-2-delta ligands, among other drugs. Furthermore, other measures can contribute to the treatment of the condition, such as iron replacement. Considerations: RLS is a complex disorder, the pathophysiology of which is not yet completely understood. Among the multiple factors, the genetic contribution, peripheral and cerebral iron deficiency and dopaminergic dysregulation stand out. Treatment of RLS involves pharmacological and non-pharmacological interventions. The choice of pharmacological treatment is based on its effectiveness in treating the primary symptoms and associated comorbidities. |
id |
GOE-1_7d4f5b193dd176c1a913bcc27798bbb5 |
---|---|
oai_identifier_str |
oai:ojs.bjihs.emnuvens.com.br:article/1798 |
network_acronym_str |
GOE-1 |
network_name_str |
Brazilian Journal of Implantology and Health Sciences |
repository_id_str |
|
spelling |
Restless legs syndrome: pathophysiological and therapeutic basesSíndrome das Pernas Inquietas: Bases Fisiopatológicas e Terapêuticassíndrome das pernas inquietastratamentofisiopatologiamanejorestless legs syndrometreatmentpathophysiologymanagementIntroduction: Restless Legs Syndrome (RLS), also known as Willis-Ekbom Disease, is a chronic neurological disorder characterized by unpleasant and irresistible sensations in the legs, usually during periods of rest or inactivity, which result in an uncontrollable desire to move the affected members. Objective: To evaluate the pathophysiological and therapeutic bases associated with restless legs syndrome. Methodology: This is a bibliographic review that included original articles and systematic reviews in English and Portuguese, which addressed pathophysiological aspects and management of SIP, published between 2014 and 2024, selected from the PubMed, Scopus and SciELO databases. After careful selection, 19 articles were chosen to compose this bibliographic review. Results: The condition presents a broad pathophysiological pattern, with several relevant aspects, including genetic characteristics, such as the dominant pattern and interaction at specific loci. In addition to environmental aspects, such as dysregulation of the dopaminergic system, which corroborates the symptomatology of the condition, as well as peripheral and cerebral iron deficit, which is considered a key biological factor in RLS. The management of RLS is diverse and involves non-pharmacological interventions, such as massage and walking, which can complement drug therapy. The choice of pharmacological treatment is individualized and uses dopaminergic agonists, alpha-2-delta ligands, among other drugs. Furthermore, other measures can contribute to the treatment of the condition, such as iron replacement. Considerations: RLS is a complex disorder, the pathophysiology of which is not yet completely understood. Among the multiple factors, the genetic contribution, peripheral and cerebral iron deficiency and dopaminergic dysregulation stand out. Treatment of RLS involves pharmacological and non-pharmacological interventions. The choice of pharmacological treatment is based on its effectiveness in treating the primary symptoms and associated comorbidities.Introdução: A Síndrome das Pernas Inquietas (SPI), também conhecida como Doença de Willis-Ekbom, é uma desordem neurológica crônica caracterizada por sensações desagradáveis e irresistíveis nas pernas, geralmente durante períodos de repouso ou inatividade, que resultam em um desejo incontrolável de movimentar os membros afetados. Objetivo: Avaliar as bases fisiopatológicas e terapêuticas associadas à síndrome das pernas inquietas. Metodologia: Trata-se de uma revisão bibliográfica que incluiu artigos originais e revisões sistemáticas em inglês e português, que abordaram aspectos fisiopatológicos e manejo da SIP, publicados entre 2014 e 2024, selecionados nas bases de dados PubMed, Scopus e SciELO. Após a seleção criteriosa, foram escolhidos 19 artigos para compor esta revisão bibliográfica. Resultados: O quadro apresenta um padrão fisiopatológico amplo, com diversos aspectos relevantes, incluindo características genéticas, como o padrão dominante e a interação em loci específicos. Além de aspectos ambientais, como a desregulação do sistema dopaminérgico, que corrobora para a sintomatologia do quadro, como também o déficit de ferro periférico e cerebral, sendo considerado um fator biológico-chave na SPI. O manejo da SPI é diverso e envolve intervenções não farmacológicas, como massagem e prática de caminhada, podem complementar a terapia medicamentosa. A escolha do tratamento farmacológico é individualizado e utiliza agonistas dopaminérgicos, ligantes alfa-2-delta, entre outros fármacos. Ademais, outras medidas podem contribuir com a terapêutica do quadro, como a reposição de ferro. Considerações: A SPI é um distúrbio complexo, cuja fisiopatologia ainda não está completamente esclarecida. Dentre os múltiplos fatores, destacam-se a contribuição genética, a deficiência de ferro periférico e cerebral e a desregulação dopaminérgica. O tratamento da SPI envolve intervenções farmacológicas e não farmacológicas. A escolha do tratamento farmacológico é baseada na eficácia em tratar os sintomas primários e as comorbidades associadas.Specialized Dentistry Group2024-03-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/179810.36557/2674-8169.2024v6n3p2797-2807Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 3 (2024): BJIHS QUALIS B3; 2797-2807Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 3 (2024): BJIHS QUALIS B3; 2797-2807Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 3 (2024): BJIHS QUALIS B3; 2797-28072674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/1798/2004Copyright (c) 2024 Paulo Vytor Cardoso Nobre, Pedro Henrique Costa de Oliveira, José César De Oliveira Cerqueira , Vinicius Cerqueira de Barros Silveira, Maria Eduarda do Amaral Silva Vasconcelos, Natália Calazans de Souza, Josivaldo de Araújo Alves Júnior , Rafael Cerqueira de Barros Silveira , Matheus Gringo Silva Santos , Igor Ribeiro Freire, Guilherme Henrique do Nascimento Silva, Igor Macedo Ferreirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessVytor Cardoso Nobre, PauloHenrique Costa de Oliveira, PedroCésar De Oliveira Cerqueira , JoséCerqueira de Barros Silveira, ViniciusEduarda do Amaral Silva Vasconcelos, MariaCalazans de Souza, Natáliade Araújo Alves Júnior , JosivaldoCerqueira de Barros Silveira , RafaelGringo Silva Santos , MatheusRibeiro Freire, IgorHenrique do Nascimento Silva, GuilhermeMacedo Ferreira, Igor2024-03-30T19:37:07Zoai:ojs.bjihs.emnuvens.com.br:article/1798Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2024-03-30T19:37:07Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
Restless legs syndrome: pathophysiological and therapeutic bases Síndrome das Pernas Inquietas: Bases Fisiopatológicas e Terapêuticas |
title |
Restless legs syndrome: pathophysiological and therapeutic bases |
spellingShingle |
Restless legs syndrome: pathophysiological and therapeutic bases Vytor Cardoso Nobre, Paulo síndrome das pernas inquietas tratamento fisiopatologia manejo restless legs syndrome treatment pathophysiology management |
title_short |
Restless legs syndrome: pathophysiological and therapeutic bases |
title_full |
Restless legs syndrome: pathophysiological and therapeutic bases |
title_fullStr |
Restless legs syndrome: pathophysiological and therapeutic bases |
title_full_unstemmed |
Restless legs syndrome: pathophysiological and therapeutic bases |
title_sort |
Restless legs syndrome: pathophysiological and therapeutic bases |
author |
Vytor Cardoso Nobre, Paulo |
author_facet |
Vytor Cardoso Nobre, Paulo Henrique Costa de Oliveira, Pedro César De Oliveira Cerqueira , José Cerqueira de Barros Silveira, Vinicius Eduarda do Amaral Silva Vasconcelos, Maria Calazans de Souza, Natália de Araújo Alves Júnior , Josivaldo Cerqueira de Barros Silveira , Rafael Gringo Silva Santos , Matheus Ribeiro Freire, Igor Henrique do Nascimento Silva, Guilherme Macedo Ferreira, Igor |
author_role |
author |
author2 |
Henrique Costa de Oliveira, Pedro César De Oliveira Cerqueira , José Cerqueira de Barros Silveira, Vinicius Eduarda do Amaral Silva Vasconcelos, Maria Calazans de Souza, Natália de Araújo Alves Júnior , Josivaldo Cerqueira de Barros Silveira , Rafael Gringo Silva Santos , Matheus Ribeiro Freire, Igor Henrique do Nascimento Silva, Guilherme Macedo Ferreira, Igor |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Vytor Cardoso Nobre, Paulo Henrique Costa de Oliveira, Pedro César De Oliveira Cerqueira , José Cerqueira de Barros Silveira, Vinicius Eduarda do Amaral Silva Vasconcelos, Maria Calazans de Souza, Natália de Araújo Alves Júnior , Josivaldo Cerqueira de Barros Silveira , Rafael Gringo Silva Santos , Matheus Ribeiro Freire, Igor Henrique do Nascimento Silva, Guilherme Macedo Ferreira, Igor |
dc.subject.por.fl_str_mv |
síndrome das pernas inquietas tratamento fisiopatologia manejo restless legs syndrome treatment pathophysiology management |
topic |
síndrome das pernas inquietas tratamento fisiopatologia manejo restless legs syndrome treatment pathophysiology management |
description |
Introduction: Restless Legs Syndrome (RLS), also known as Willis-Ekbom Disease, is a chronic neurological disorder characterized by unpleasant and irresistible sensations in the legs, usually during periods of rest or inactivity, which result in an uncontrollable desire to move the affected members. Objective: To evaluate the pathophysiological and therapeutic bases associated with restless legs syndrome. Methodology: This is a bibliographic review that included original articles and systematic reviews in English and Portuguese, which addressed pathophysiological aspects and management of SIP, published between 2014 and 2024, selected from the PubMed, Scopus and SciELO databases. After careful selection, 19 articles were chosen to compose this bibliographic review. Results: The condition presents a broad pathophysiological pattern, with several relevant aspects, including genetic characteristics, such as the dominant pattern and interaction at specific loci. In addition to environmental aspects, such as dysregulation of the dopaminergic system, which corroborates the symptomatology of the condition, as well as peripheral and cerebral iron deficit, which is considered a key biological factor in RLS. The management of RLS is diverse and involves non-pharmacological interventions, such as massage and walking, which can complement drug therapy. The choice of pharmacological treatment is individualized and uses dopaminergic agonists, alpha-2-delta ligands, among other drugs. Furthermore, other measures can contribute to the treatment of the condition, such as iron replacement. Considerations: RLS is a complex disorder, the pathophysiology of which is not yet completely understood. Among the multiple factors, the genetic contribution, peripheral and cerebral iron deficiency and dopaminergic dysregulation stand out. Treatment of RLS involves pharmacological and non-pharmacological interventions. The choice of pharmacological treatment is based on its effectiveness in treating the primary symptoms and associated comorbidities. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-03-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1798 10.36557/2674-8169.2024v6n3p2797-2807 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/1798 |
identifier_str_mv |
10.36557/2674-8169.2024v6n3p2797-2807 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1798/2004 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 3 (2024): BJIHS QUALIS B3; 2797-2807 Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 3 (2024): BJIHS QUALIS B3; 2797-2807 Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 3 (2024): BJIHS QUALIS B3; 2797-2807 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
_version_ |
1796798446855782400 |