Latent autoimmune diabetes of adults (LADA): overview of pathogenesis, risck factors and treatment

• Autor(a) principal: Nobre, Paulo Vytor Cardoso
• Data de Publicação: 2024
• Outros Autores: Cavalcante , Flávia Maria Silva, Ribeiro, Nayara Fernanda Amorim Madeiros, Cavalcanti, Fernanda Maria Silva, Batista, Alícia Caroline da Silva, Lacerda, Ana Klívia Vasconcelos, Dias, Victor Raposo Lima, Roza, Isadora Fonseca Santa, Ferreira, Luma waleska lobo Lou, Macena, Leopoldo Baracho, Cerqueira, José César De Oliveira
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1681
• topic: diabetes autoimune latente do adulto; fatores de risco; patogênese; tratamento; adult latent autoimmune diabetes; risk factors; pathogenesis; treatment

Introduction: LADA, or Latent Autoimmune Diabetes of Adults, is a condition characterized by disorders of insulin action and secretion, due to the presence of pancreatic autoantibodies, such as those against GADA. Objective: to evaluate the pathogenesis, risk factors and management of latent autoimmune diabetes in adults. Methodology: This is a bibliographic review that included original articles and systematic reviews in English and Portuguese, which addressed the risk factors, pathogenic components and treatment of LADA, published between 2016 and 2024, selected from the databases PubMed, Scopus and SciELO. After careful selection, 18 articles were chosen to compose this bibliographic review. Result and discussions: The destruction of pancreatic cells is slower than in DM1. Genetic and lifestyle factors, such as excess weight and diet, influence its development. Treatment involves lifestyle changes and insulin therapy, aimed at preserving beta cells and modulating the immune response. Considerations: LADA is a complex condition with genetic and environmental influence, and the various factors that influence the onset of the condition are well known. An integrated and multidisciplinary approach is essential to improve patients quality of life.