Pediatric Leukemia: A Comprehensive Analysis of Current Therapies and Research Perspectives.

• Autor(a) principal: de Alencar Costa, Júlio César
• Data de Publicação: 2023
• Outros Autores: Soares Pereira, Livia, Ferreira Alves Trindade, Juliana, Vasconcelos Lovaglio , Letícia, Mozdzen dos Passos , Gabriela
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• DOI: 10.36557/2674-8169.2023v5n5p1829-1841
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/749
• topic: Leucemia; intervenções farmacológicas; Leukemia

Childhood cancer, especially pediatric leukemia, is a complex and challenging medical condition. The present study aims to conduct a comprehensive analysis of pharmacological approaches used in the treatment of pediatric leukemia, with an emphasis on contemporary strategies. Understanding these interventions is of vital importance to optimize clinical management and enhance the quality of life for affected children. An integrative literature review was conducted, involving a thorough search for scientific articles in indexed databases, using specific descriptors related to pediatric leukemia and pharmacological interventions. Studies investigating the effectiveness of different drugs in treating leukemia were selected, prioritizing contemporary and relevant approaches. The references were meticulously analyzed and organized following the Vancouver style. Several pharmacological interventions were identified as fundamental components in the treatment of pediatric leukemia. Noteworthy among them are KIR-mismatched unrelated donor stem cell transplantation with in vivo T cell depletion in AML, as well as the effectiveness of blinatumomab in the treatment of pediatric acute lymphoblastic leukemia, among other approaches to be addressed in the course of the study. This integrative review highlights the diversity of pharmacological interventions available for the treatment of pediatric leukemia. It also underscores the need for an individualized and multidisciplinary approach, where treatment customization, taking into account the individual characteristics and clinical peculiarities of each patient, is crucial. Additionally, it is imperative to rigorously monitor the long-term safety and effectiveness of pharmacological interventions.