GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT

Detalhes bibliográficos
Autor(a) principal: Neto, Francisco Leite do Amaral
Data de Publicação: 2024
Outros Autores: Oliveira, Guilherme Miranda de, Eigenheer , Laura de Vasconcelos, Azevedo , Stefany Abreu de, Eigenheer, Arthur de Vasconcelos, Almeida, Gabriel Torres Souza de, Ibiapina, Maria de Lourdes Pereira, Gomes, Vycthoria Stampini, Bezerra , Thuane do Nascimento, Ribeiro , Priscila Leite Loiola, Bezerra, Thuane do Nascimento, Silva, Graziella Viana da, Silva, Marcos Fernandes da, Moraes , Laura Paes, Freitas , Ana Cristina Guedes de, Inacio, Rafael de Oliveira, Cunha, Ursula Amanda Sa da, Souza, Vanessa de Oliveira Ferreira Borges de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Brazilian Journal of Implantology and Health Sciences
Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1573
Resumo: In this literature review, the general objective is to provide a comprehensive and updated analysis of the pathophysiological aspects and treatment of Gestational Trophoblastic Disease (GTD). The specific objectives seek to present a critical discussion of the results found to inform health professionals and contribute to more effective approaches in the management of this clinical condition, in addition to increasing awareness about GTD and improving emotional and psychosocial support for women facing this disease. GTD is a rare but serious condition that requires accurate diagnosis and a multidisciplinary approach. The main initial detection methods are serum hCG measurement and ultrasound, with histopathological analysis of endometrial biopsy necessary for diagnostic confirmation. The type of DTG identified is crucial in determining the most appropriate therapeutic approach. Treatment involves surgery to remove the molar placenta in complete hydatidiform moles and chemotherapy for choriocarcinoma and trophoblastic tumor of the placental site, generally presenting positive results with high remission and cure rates, although long-term follow-up is essential to detect recurrences. and complications. In addition to the pathophysiological and therapeutic aspects, emotional and psychological support is essential throughout the treatment and recovery process, considering the significant impact on patients' emotional health. Knowledge gaps were identified in the reviewed literature, highlighting the need for additional research to deepen the understanding of GTD, including risk factors, pathogenesis, more accurate biomarkers and new therapeutic approaches, in order to improve the management and prognosis of the disease. In conclusion, this bibliographical review contributes to the knowledge of GTD, highlighting its characteristics, diagnosis and treatment, and emphasizes the importance of a multidisciplinary approach to ensure adequate care, considering clinical, emotional and practical aspects of patients, in addition to encouraging new research to improve the care of these women facing this complex condition.
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spelling GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT DOENÇA TROFOBLÁSTICA GESTACIONAL: ASPECTOS FISIOPATOLÓGICOS E TRATAMENTOGestação; Doença Trofoblástica Gestacional; Diagnósticos; Tratamentos.Quality of life, Satisfaction, Mucus-supported complete denture, Implant-supported complete denture.In this literature review, the general objective is to provide a comprehensive and updated analysis of the pathophysiological aspects and treatment of Gestational Trophoblastic Disease (GTD). The specific objectives seek to present a critical discussion of the results found to inform health professionals and contribute to more effective approaches in the management of this clinical condition, in addition to increasing awareness about GTD and improving emotional and psychosocial support for women facing this disease. GTD is a rare but serious condition that requires accurate diagnosis and a multidisciplinary approach. The main initial detection methods are serum hCG measurement and ultrasound, with histopathological analysis of endometrial biopsy necessary for diagnostic confirmation. The type of DTG identified is crucial in determining the most appropriate therapeutic approach. Treatment involves surgery to remove the molar placenta in complete hydatidiform moles and chemotherapy for choriocarcinoma and trophoblastic tumor of the placental site, generally presenting positive results with high remission and cure rates, although long-term follow-up is essential to detect recurrences. and complications. In addition to the pathophysiological and therapeutic aspects, emotional and psychological support is essential throughout the treatment and recovery process, considering the significant impact on patients' emotional health. Knowledge gaps were identified in the reviewed literature, highlighting the need for additional research to deepen the understanding of GTD, including risk factors, pathogenesis, more accurate biomarkers and new therapeutic approaches, in order to improve the management and prognosis of the disease. In conclusion, this bibliographical review contributes to the knowledge of GTD, highlighting its characteristics, diagnosis and treatment, and emphasizes the importance of a multidisciplinary approach to ensure adequate care, considering clinical, emotional and practical aspects of patients, in addition to encouraging new research to improve the care of these women facing this complex condition.Neste trabalho de revisão bibliográfica, o objetivo geral é fornecer uma análise abrangente e atualizada dos aspectos fisiopatológicos e tratamento da Doença Trofoblástica Gestacional (DTG). Os objetivos específicos buscam apresentar uma discussão crítica dos resultados encontrados para informar profissionais de saúde e contribuir com abordagens mais eficazes no manejo dessa condição clínica, além de aumentar a conscientização sobre a DTG e melhorar o suporte emocional e psicossocial às mulheres enfrentando essa doença. A DTG é uma condição rara, mas grave, que requer diagnóstico preciso e abordagem multidisciplinar. Os principais métodos de detecção inicial são a dosagem sérica de hCG e a ultrassonografia, sendo a análise histopatológica de biópsia endometrial necessária para confirmação diagnóstica. O tipo de DTG identificado é crucial para determinar a abordagem terapêutica mais adequada. O tratamento envolve cirurgia para remoção da placenta molar em molas hidatiformes completas e quimioterapia para o coriocarcinoma e o tumor trofoblástico do sítio placentário, apresentando geralmente resultados positivos com altas taxas de remissão e cura, embora o acompanhamento a longo prazo seja essencial para detecção de recorrências e complicações. Além dos aspectos fisiopatológicos e terapêuticos, o suporte emocional e psicológico é fundamental durante todo o processo de tratamento e recuperação, considerando o impacto significativo na saúde emocional das pacientes. Identificaram-se lacunas de conhecimento na literatura revisada, ressaltando a necessidade de pesquisas adicionais para aprofundar a compreensão da DTG, incluindo fatores de risco, patogênese, biomarcadores mais precisos e novas abordagens terapêuticas, a fim de melhorar o manejo e o prognóstico da doença. Em conclusão, esta revisão bibliográfica contribui para o conhecimento da DTG, destacando suas características, diagnóstico e tratamento, e enfatiza a importância de uma abordagem multidisciplinar para garantir cuidado adequado, considerando aspectos clínicos, emocionais e práticos das pacientes, além de incentivar novas pesquisas para aprimorar o cuidado dessas mulheres enfrentando essa condição complexa.Specialized Dentistry Group2024-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/157310.36557/2674-8169.2024v6n3p12-26Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 3 (2024): BJIHS QUALIS B3; 12-26Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 3 (2024): BJIHS QUALIS B3; 12-26Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 3 (2024): BJIHS QUALIS B3; 12-262674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/1573/1762Copyright (c) 2024 Francisco Leite do Amaral Neto, Guilherme Miranda de Oliveira, Laura de Vasconcelos Eigenheer , Stefany Abreu de Azevedo , Arthur de Vasconcelos Eigenheer, Gabriel Torres Souza de Almeida, Maria de Lourdes Pereira Ibiapina, Vycthoria Stampini Gomes, Thuane do Nascimento Bezerra , Priscila Leite Loiola Ribeiro , Thuane do Nascimento Bezerra, Graziella Viana da Silva, Marcos Fernandes da Silva, Laura Paes Moraes , Ana Cristina Guedes de Freitas , Rafael de Oliveira Inacio, Ursula Amanda Sa da Cunha, Vanessa de Oliveira Ferreira Borges de Souzahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Neto, Francisco Leite do AmaralOliveira, Guilherme Miranda deEigenheer , Laura de VasconcelosAzevedo , Stefany Abreu deEigenheer, Arthur de VasconcelosAlmeida, Gabriel Torres Souza deIbiapina, Maria de Lourdes PereiraGomes, Vycthoria StampiniBezerra , Thuane do NascimentoRibeiro , Priscila Leite LoiolaBezerra, Thuane do NascimentoSilva, Graziella Viana daSilva, Marcos Fernandes daMoraes , Laura Paes Freitas , Ana Cristina Guedes de Inacio, Rafael de OliveiraCunha, Ursula Amanda Sa daSouza, Vanessa de Oliveira Ferreira Borges de2024-03-01T21:56:21Zoai:ojs.bjihs.emnuvens.com.br:article/1573Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2024-03-01T21:56:21Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false
dc.title.none.fl_str_mv GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT
DOENÇA TROFOBLÁSTICA GESTACIONAL: ASPECTOS FISIOPATOLÓGICOS E TRATAMENTO
title GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT
spellingShingle GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT
Neto, Francisco Leite do Amaral
Gestação; Doença Trofoblástica Gestacional; Diagnósticos; Tratamentos.
Quality of life, Satisfaction, Mucus-supported complete denture, Implant-supported complete denture.
title_short GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT
title_full GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT
title_fullStr GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT
title_full_unstemmed GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT
title_sort GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT
author Neto, Francisco Leite do Amaral
author_facet Neto, Francisco Leite do Amaral
Oliveira, Guilherme Miranda de
Eigenheer , Laura de Vasconcelos
Azevedo , Stefany Abreu de
Eigenheer, Arthur de Vasconcelos
Almeida, Gabriel Torres Souza de
Ibiapina, Maria de Lourdes Pereira
Gomes, Vycthoria Stampini
Bezerra , Thuane do Nascimento
Ribeiro , Priscila Leite Loiola
Bezerra, Thuane do Nascimento
Silva, Graziella Viana da
Silva, Marcos Fernandes da
Moraes , Laura Paes
Freitas , Ana Cristina Guedes de
Inacio, Rafael de Oliveira
Cunha, Ursula Amanda Sa da
Souza, Vanessa de Oliveira Ferreira Borges de
author_role author
author2 Oliveira, Guilherme Miranda de
Eigenheer , Laura de Vasconcelos
Azevedo , Stefany Abreu de
Eigenheer, Arthur de Vasconcelos
Almeida, Gabriel Torres Souza de
Ibiapina, Maria de Lourdes Pereira
Gomes, Vycthoria Stampini
Bezerra , Thuane do Nascimento
Ribeiro , Priscila Leite Loiola
Bezerra, Thuane do Nascimento
Silva, Graziella Viana da
Silva, Marcos Fernandes da
Moraes , Laura Paes
Freitas , Ana Cristina Guedes de
Inacio, Rafael de Oliveira
Cunha, Ursula Amanda Sa da
Souza, Vanessa de Oliveira Ferreira Borges de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Neto, Francisco Leite do Amaral
Oliveira, Guilherme Miranda de
Eigenheer , Laura de Vasconcelos
Azevedo , Stefany Abreu de
Eigenheer, Arthur de Vasconcelos
Almeida, Gabriel Torres Souza de
Ibiapina, Maria de Lourdes Pereira
Gomes, Vycthoria Stampini
Bezerra , Thuane do Nascimento
Ribeiro , Priscila Leite Loiola
Bezerra, Thuane do Nascimento
Silva, Graziella Viana da
Silva, Marcos Fernandes da
Moraes , Laura Paes
Freitas , Ana Cristina Guedes de
Inacio, Rafael de Oliveira
Cunha, Ursula Amanda Sa da
Souza, Vanessa de Oliveira Ferreira Borges de
dc.subject.por.fl_str_mv Gestação; Doença Trofoblástica Gestacional; Diagnósticos; Tratamentos.
Quality of life, Satisfaction, Mucus-supported complete denture, Implant-supported complete denture.
topic Gestação; Doença Trofoblástica Gestacional; Diagnósticos; Tratamentos.
Quality of life, Satisfaction, Mucus-supported complete denture, Implant-supported complete denture.
description In this literature review, the general objective is to provide a comprehensive and updated analysis of the pathophysiological aspects and treatment of Gestational Trophoblastic Disease (GTD). The specific objectives seek to present a critical discussion of the results found to inform health professionals and contribute to more effective approaches in the management of this clinical condition, in addition to increasing awareness about GTD and improving emotional and psychosocial support for women facing this disease. GTD is a rare but serious condition that requires accurate diagnosis and a multidisciplinary approach. The main initial detection methods are serum hCG measurement and ultrasound, with histopathological analysis of endometrial biopsy necessary for diagnostic confirmation. The type of DTG identified is crucial in determining the most appropriate therapeutic approach. Treatment involves surgery to remove the molar placenta in complete hydatidiform moles and chemotherapy for choriocarcinoma and trophoblastic tumor of the placental site, generally presenting positive results with high remission and cure rates, although long-term follow-up is essential to detect recurrences. and complications. In addition to the pathophysiological and therapeutic aspects, emotional and psychological support is essential throughout the treatment and recovery process, considering the significant impact on patients' emotional health. Knowledge gaps were identified in the reviewed literature, highlighting the need for additional research to deepen the understanding of GTD, including risk factors, pathogenesis, more accurate biomarkers and new therapeutic approaches, in order to improve the management and prognosis of the disease. In conclusion, this bibliographical review contributes to the knowledge of GTD, highlighting its characteristics, diagnosis and treatment, and emphasizes the importance of a multidisciplinary approach to ensure adequate care, considering clinical, emotional and practical aspects of patients, in addition to encouraging new research to improve the care of these women facing this complex condition.
publishDate 2024
dc.date.none.fl_str_mv 2024-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://bjihs.emnuvens.com.br/bjihs/article/view/1573
10.36557/2674-8169.2024v6n3p12-26
url https://bjihs.emnuvens.com.br/bjihs/article/view/1573
identifier_str_mv 10.36557/2674-8169.2024v6n3p12-26
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://bjihs.emnuvens.com.br/bjihs/article/view/1573/1762
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Specialized Dentistry Group
publisher.none.fl_str_mv Specialized Dentistry Group
dc.source.none.fl_str_mv Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 3 (2024): BJIHS QUALIS B3; 12-26
Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 3 (2024): BJIHS QUALIS B3; 12-26
Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 3 (2024): BJIHS QUALIS B3; 12-26
2674-8169
reponame:Brazilian Journal of Implantology and Health Sciences
instname:Grupo de Odontologia Especializada (GOE)
instacron:GOE
instname_str Grupo de Odontologia Especializada (GOE)
instacron_str GOE
institution GOE
reponame_str Brazilian Journal of Implantology and Health Sciences
collection Brazilian Journal of Implantology and Health Sciences
repository.name.fl_str_mv Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)
repository.mail.fl_str_mv journal.bjihs@periodicosbrasil.com.br
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