GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/1573 |
Resumo: | In this literature review, the general objective is to provide a comprehensive and updated analysis of the pathophysiological aspects and treatment of Gestational Trophoblastic Disease (GTD). The specific objectives seek to present a critical discussion of the results found to inform health professionals and contribute to more effective approaches in the management of this clinical condition, in addition to increasing awareness about GTD and improving emotional and psychosocial support for women facing this disease. GTD is a rare but serious condition that requires accurate diagnosis and a multidisciplinary approach. The main initial detection methods are serum hCG measurement and ultrasound, with histopathological analysis of endometrial biopsy necessary for diagnostic confirmation. The type of DTG identified is crucial in determining the most appropriate therapeutic approach. Treatment involves surgery to remove the molar placenta in complete hydatidiform moles and chemotherapy for choriocarcinoma and trophoblastic tumor of the placental site, generally presenting positive results with high remission and cure rates, although long-term follow-up is essential to detect recurrences. and complications. In addition to the pathophysiological and therapeutic aspects, emotional and psychological support is essential throughout the treatment and recovery process, considering the significant impact on patients' emotional health. Knowledge gaps were identified in the reviewed literature, highlighting the need for additional research to deepen the understanding of GTD, including risk factors, pathogenesis, more accurate biomarkers and new therapeutic approaches, in order to improve the management and prognosis of the disease. In conclusion, this bibliographical review contributes to the knowledge of GTD, highlighting its characteristics, diagnosis and treatment, and emphasizes the importance of a multidisciplinary approach to ensure adequate care, considering clinical, emotional and practical aspects of patients, in addition to encouraging new research to improve the care of these women facing this complex condition. |
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GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT DOENÇA TROFOBLÁSTICA GESTACIONAL: ASPECTOS FISIOPATOLÓGICOS E TRATAMENTOGestação; Doença Trofoblástica Gestacional; Diagnósticos; Tratamentos.Quality of life, Satisfaction, Mucus-supported complete denture, Implant-supported complete denture.In this literature review, the general objective is to provide a comprehensive and updated analysis of the pathophysiological aspects and treatment of Gestational Trophoblastic Disease (GTD). The specific objectives seek to present a critical discussion of the results found to inform health professionals and contribute to more effective approaches in the management of this clinical condition, in addition to increasing awareness about GTD and improving emotional and psychosocial support for women facing this disease. GTD is a rare but serious condition that requires accurate diagnosis and a multidisciplinary approach. The main initial detection methods are serum hCG measurement and ultrasound, with histopathological analysis of endometrial biopsy necessary for diagnostic confirmation. The type of DTG identified is crucial in determining the most appropriate therapeutic approach. Treatment involves surgery to remove the molar placenta in complete hydatidiform moles and chemotherapy for choriocarcinoma and trophoblastic tumor of the placental site, generally presenting positive results with high remission and cure rates, although long-term follow-up is essential to detect recurrences. and complications. In addition to the pathophysiological and therapeutic aspects, emotional and psychological support is essential throughout the treatment and recovery process, considering the significant impact on patients' emotional health. Knowledge gaps were identified in the reviewed literature, highlighting the need for additional research to deepen the understanding of GTD, including risk factors, pathogenesis, more accurate biomarkers and new therapeutic approaches, in order to improve the management and prognosis of the disease. In conclusion, this bibliographical review contributes to the knowledge of GTD, highlighting its characteristics, diagnosis and treatment, and emphasizes the importance of a multidisciplinary approach to ensure adequate care, considering clinical, emotional and practical aspects of patients, in addition to encouraging new research to improve the care of these women facing this complex condition.Neste trabalho de revisão bibliográfica, o objetivo geral é fornecer uma análise abrangente e atualizada dos aspectos fisiopatológicos e tratamento da Doença Trofoblástica Gestacional (DTG). Os objetivos específicos buscam apresentar uma discussão crítica dos resultados encontrados para informar profissionais de saúde e contribuir com abordagens mais eficazes no manejo dessa condição clínica, além de aumentar a conscientização sobre a DTG e melhorar o suporte emocional e psicossocial às mulheres enfrentando essa doença. A DTG é uma condição rara, mas grave, que requer diagnóstico preciso e abordagem multidisciplinar. Os principais métodos de detecção inicial são a dosagem sérica de hCG e a ultrassonografia, sendo a análise histopatológica de biópsia endometrial necessária para confirmação diagnóstica. O tipo de DTG identificado é crucial para determinar a abordagem terapêutica mais adequada. O tratamento envolve cirurgia para remoção da placenta molar em molas hidatiformes completas e quimioterapia para o coriocarcinoma e o tumor trofoblástico do sítio placentário, apresentando geralmente resultados positivos com altas taxas de remissão e cura, embora o acompanhamento a longo prazo seja essencial para detecção de recorrências e complicações. Além dos aspectos fisiopatológicos e terapêuticos, o suporte emocional e psicológico é fundamental durante todo o processo de tratamento e recuperação, considerando o impacto significativo na saúde emocional das pacientes. Identificaram-se lacunas de conhecimento na literatura revisada, ressaltando a necessidade de pesquisas adicionais para aprofundar a compreensão da DTG, incluindo fatores de risco, patogênese, biomarcadores mais precisos e novas abordagens terapêuticas, a fim de melhorar o manejo e o prognóstico da doença. Em conclusão, esta revisão bibliográfica contribui para o conhecimento da DTG, destacando suas características, diagnóstico e tratamento, e enfatiza a importância de uma abordagem multidisciplinar para garantir cuidado adequado, considerando aspectos clínicos, emocionais e práticos das pacientes, além de incentivar novas pesquisas para aprimorar o cuidado dessas mulheres enfrentando essa condição complexa.Specialized Dentistry Group2024-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/157310.36557/2674-8169.2024v6n3p12-26Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 3 (2024): BJIHS QUALIS B3; 12-26Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 3 (2024): BJIHS QUALIS B3; 12-26Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 3 (2024): BJIHS QUALIS B3; 12-262674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/1573/1762Copyright (c) 2024 Francisco Leite do Amaral Neto, Guilherme Miranda de Oliveira, Laura de Vasconcelos Eigenheer , Stefany Abreu de Azevedo , Arthur de Vasconcelos Eigenheer, Gabriel Torres Souza de Almeida, Maria de Lourdes Pereira Ibiapina, Vycthoria Stampini Gomes, Thuane do Nascimento Bezerra , Priscila Leite Loiola Ribeiro , Thuane do Nascimento Bezerra, Graziella Viana da Silva, Marcos Fernandes da Silva, Laura Paes Moraes , Ana Cristina Guedes de Freitas , Rafael de Oliveira Inacio, Ursula Amanda Sa da Cunha, Vanessa de Oliveira Ferreira Borges de Souzahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Neto, Francisco Leite do AmaralOliveira, Guilherme Miranda deEigenheer , Laura de VasconcelosAzevedo , Stefany Abreu deEigenheer, Arthur de VasconcelosAlmeida, Gabriel Torres Souza deIbiapina, Maria de Lourdes PereiraGomes, Vycthoria StampiniBezerra , Thuane do NascimentoRibeiro , Priscila Leite LoiolaBezerra, Thuane do NascimentoSilva, Graziella Viana daSilva, Marcos Fernandes daMoraes , Laura Paes Freitas , Ana Cristina Guedes de Inacio, Rafael de OliveiraCunha, Ursula Amanda Sa daSouza, Vanessa de Oliveira Ferreira Borges de2024-03-01T21:56:21Zoai:ojs.bjihs.emnuvens.com.br:article/1573Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2024-03-01T21:56:21Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT DOENÇA TROFOBLÁSTICA GESTACIONAL: ASPECTOS FISIOPATOLÓGICOS E TRATAMENTO |
title |
GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT |
spellingShingle |
GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT Neto, Francisco Leite do Amaral Gestação; Doença Trofoblástica Gestacional; Diagnósticos; Tratamentos. Quality of life, Satisfaction, Mucus-supported complete denture, Implant-supported complete denture. |
title_short |
GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT |
title_full |
GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT |
title_fullStr |
GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT |
title_full_unstemmed |
GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT |
title_sort |
GESTATIONAL TROPHOBLASTIC DISEASE: PHYSIOPATHOLOGICAL ASPECTS AND TREATMENT |
author |
Neto, Francisco Leite do Amaral |
author_facet |
Neto, Francisco Leite do Amaral Oliveira, Guilherme Miranda de Eigenheer , Laura de Vasconcelos Azevedo , Stefany Abreu de Eigenheer, Arthur de Vasconcelos Almeida, Gabriel Torres Souza de Ibiapina, Maria de Lourdes Pereira Gomes, Vycthoria Stampini Bezerra , Thuane do Nascimento Ribeiro , Priscila Leite Loiola Bezerra, Thuane do Nascimento Silva, Graziella Viana da Silva, Marcos Fernandes da Moraes , Laura Paes Freitas , Ana Cristina Guedes de Inacio, Rafael de Oliveira Cunha, Ursula Amanda Sa da Souza, Vanessa de Oliveira Ferreira Borges de |
author_role |
author |
author2 |
Oliveira, Guilherme Miranda de Eigenheer , Laura de Vasconcelos Azevedo , Stefany Abreu de Eigenheer, Arthur de Vasconcelos Almeida, Gabriel Torres Souza de Ibiapina, Maria de Lourdes Pereira Gomes, Vycthoria Stampini Bezerra , Thuane do Nascimento Ribeiro , Priscila Leite Loiola Bezerra, Thuane do Nascimento Silva, Graziella Viana da Silva, Marcos Fernandes da Moraes , Laura Paes Freitas , Ana Cristina Guedes de Inacio, Rafael de Oliveira Cunha, Ursula Amanda Sa da Souza, Vanessa de Oliveira Ferreira Borges de |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Neto, Francisco Leite do Amaral Oliveira, Guilherme Miranda de Eigenheer , Laura de Vasconcelos Azevedo , Stefany Abreu de Eigenheer, Arthur de Vasconcelos Almeida, Gabriel Torres Souza de Ibiapina, Maria de Lourdes Pereira Gomes, Vycthoria Stampini Bezerra , Thuane do Nascimento Ribeiro , Priscila Leite Loiola Bezerra, Thuane do Nascimento Silva, Graziella Viana da Silva, Marcos Fernandes da Moraes , Laura Paes Freitas , Ana Cristina Guedes de Inacio, Rafael de Oliveira Cunha, Ursula Amanda Sa da Souza, Vanessa de Oliveira Ferreira Borges de |
dc.subject.por.fl_str_mv |
Gestação; Doença Trofoblástica Gestacional; Diagnósticos; Tratamentos. Quality of life, Satisfaction, Mucus-supported complete denture, Implant-supported complete denture. |
topic |
Gestação; Doença Trofoblástica Gestacional; Diagnósticos; Tratamentos. Quality of life, Satisfaction, Mucus-supported complete denture, Implant-supported complete denture. |
description |
In this literature review, the general objective is to provide a comprehensive and updated analysis of the pathophysiological aspects and treatment of Gestational Trophoblastic Disease (GTD). The specific objectives seek to present a critical discussion of the results found to inform health professionals and contribute to more effective approaches in the management of this clinical condition, in addition to increasing awareness about GTD and improving emotional and psychosocial support for women facing this disease. GTD is a rare but serious condition that requires accurate diagnosis and a multidisciplinary approach. The main initial detection methods are serum hCG measurement and ultrasound, with histopathological analysis of endometrial biopsy necessary for diagnostic confirmation. The type of DTG identified is crucial in determining the most appropriate therapeutic approach. Treatment involves surgery to remove the molar placenta in complete hydatidiform moles and chemotherapy for choriocarcinoma and trophoblastic tumor of the placental site, generally presenting positive results with high remission and cure rates, although long-term follow-up is essential to detect recurrences. and complications. In addition to the pathophysiological and therapeutic aspects, emotional and psychological support is essential throughout the treatment and recovery process, considering the significant impact on patients' emotional health. Knowledge gaps were identified in the reviewed literature, highlighting the need for additional research to deepen the understanding of GTD, including risk factors, pathogenesis, more accurate biomarkers and new therapeutic approaches, in order to improve the management and prognosis of the disease. In conclusion, this bibliographical review contributes to the knowledge of GTD, highlighting its characteristics, diagnosis and treatment, and emphasizes the importance of a multidisciplinary approach to ensure adequate care, considering clinical, emotional and practical aspects of patients, in addition to encouraging new research to improve the care of these women facing this complex condition. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1573 10.36557/2674-8169.2024v6n3p12-26 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/1573 |
identifier_str_mv |
10.36557/2674-8169.2024v6n3p12-26 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1573/1762 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 3 (2024): BJIHS QUALIS B3; 12-26 Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 3 (2024): BJIHS QUALIS B3; 12-26 Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 3 (2024): BJIHS QUALIS B3; 12-26 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
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1796798445616365568 |