ANÁLISE DO USO DE ANTIMICROBIANOS E O IMPACTO NA RESISTÊNCIA BACTERIANA EM PACIENTES DO CENTRO DE TERAPIA INTENSIVA DE UM HOSPITAL UNIVERSITÁRIO EM MINAS GERAIS

• Autor(a) principal: Barroso, Anna Karolina Raquel Duarte
• Data de Publicação: 2024
• Outros Autores: Silvério, Marcelo Silva, Garcia, Patrícia Guedes, Mendonça, Alessandra Esther de, Júnior, Olavo dos Santos Pereira, Soares, Windson Hebert Araújo, Fonseca, Danielle Oliveira da
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1837
• topic: Carbapenemases; Klebsiella pneumoniae produtoras de KPC; COVID-19; KPC

The present study aims to describe the profile of antimicrobial use in the Intensive Care Unit of the University Hospital of the Federal University of Juiz de Fora; analyze the results of the Antimicrobial Susceptibility Test of bacterial strains isolated from clinical specimens and evaluate the prevalence of multidrug-resistant bacterial species from the specimens. Thus, it is characterized as a retrospective descriptive cross-sectional study carried out from the analysis of patients' medical records of which, in clinical samples of tracheal aspirate, positive culture was identified for multidrug-resistant bacteria producing carbapenemases hospitalized in the period from 2020 to 2022, at the Santa Catarina University Hospital in Juiz de Fora (HU-UFJF). It was observed that factors such as: prolonged ICU stay, use of invasive devices, comorbidities, age, previous use of broad-spectrum antimicrobials, COVID co-infection, and gram-negative co-infections can contribute to a poor prognosis of patients. Despite the development of new antimicrobials, such as ceftazidime/avibactam for the treatment of carbapenemase-producing bacteria, it is necessary to implement strict measures to control the use of these drugs.