INCREASED OXIDATIVE STRESS IN THE BLOOD OF OSTOMY PATIENTS

Detalhes bibliográficos
Autor(a) principal: BAVARESCO,Daniela V
Data de Publicação: 2018
Outros Autores: SCHWALM,Mágada T, FARIAS,Beatriz M de, CERETTA,Luciane B, ROSA,Maria Inês da, VALVASSORI,Samira S
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de gastroenterologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032018000200164
Resumo: ABSTRACT BACKGROUND: Ostomy is a surgical procedure that creates a stoma that aims to construct a new path for the output of feces or urine. The relationship of oxidative stress (OxS) markers in patients with ostomy is still poorly described. OBJECTIVE: The present study was aimed at investigating the changes in oxidative stress parameters in peripheral blood collected from ostomy patients when compared with a healthy control group. METHODS: It was evaluated 29 ostomy patients and 30 healthy control patients. The oxidative stress parameters evaluated were: lipid peroxidation [lipid hydroperoxide (LPO), 8-isoprostane (8-ISO) and 4-hydroxynonenal (4-HNE)], protein oxidation and nitration [carbonyl and 3-nitrotyrosine (3-NT)] and DNA oxidation [8-hydroxy-2’-deoxyguanosine (8-OHDG)] in serum from ostomy patients compared to health controls. RESULTS: The data showed an increase of LPO, 8-ISO, 4-HNE, 3-NT and 8-OHDG in serum collected from ostomy patients when compared to healthy controls. CONCLUSION: The findings support the hypothesis that ostomy triggers the oxidative stress observed in the blood collected from these patients.
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spelling INCREASED OXIDATIVE STRESS IN THE BLOOD OF OSTOMY PATIENTSSurgical stomas, adverse effectsOxidative stressLipid peroxidationNitrationABSTRACT BACKGROUND: Ostomy is a surgical procedure that creates a stoma that aims to construct a new path for the output of feces or urine. The relationship of oxidative stress (OxS) markers in patients with ostomy is still poorly described. OBJECTIVE: The present study was aimed at investigating the changes in oxidative stress parameters in peripheral blood collected from ostomy patients when compared with a healthy control group. METHODS: It was evaluated 29 ostomy patients and 30 healthy control patients. The oxidative stress parameters evaluated were: lipid peroxidation [lipid hydroperoxide (LPO), 8-isoprostane (8-ISO) and 4-hydroxynonenal (4-HNE)], protein oxidation and nitration [carbonyl and 3-nitrotyrosine (3-NT)] and DNA oxidation [8-hydroxy-2’-deoxyguanosine (8-OHDG)] in serum from ostomy patients compared to health controls. RESULTS: The data showed an increase of LPO, 8-ISO, 4-HNE, 3-NT and 8-OHDG in serum collected from ostomy patients when compared to healthy controls. CONCLUSION: The findings support the hypothesis that ostomy triggers the oxidative stress observed in the blood collected from these patients.Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE. 2018-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032018000200164Arquivos de Gastroenterologia v.55 n.2 2018reponame:Arquivos de gastroenterologia (Online)instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiainstacron:IBEPEGE10.1590/s0004-2803.201800000-29info:eu-repo/semantics/openAccessBAVARESCO,Daniela VSCHWALM,Mágada TFARIAS,Beatriz M deCERETTA,Luciane BROSA,Maria Inês daVALVASSORI,Samira Seng2018-08-27T00:00:00Zoai:scielo:S0004-28032018000200164Revistahttp://www.scielo.br/aghttps://old.scielo.br/oai/scielo-oai.php||secretariaarqgastr@hospitaligesp.com.br1678-42190004-2803opendoar:2018-08-27T00:00Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiafalse
dc.title.none.fl_str_mv INCREASED OXIDATIVE STRESS IN THE BLOOD OF OSTOMY PATIENTS
title INCREASED OXIDATIVE STRESS IN THE BLOOD OF OSTOMY PATIENTS
spellingShingle INCREASED OXIDATIVE STRESS IN THE BLOOD OF OSTOMY PATIENTS
BAVARESCO,Daniela V
Surgical stomas, adverse effects
Oxidative stress
Lipid peroxidation
Nitration
title_short INCREASED OXIDATIVE STRESS IN THE BLOOD OF OSTOMY PATIENTS
title_full INCREASED OXIDATIVE STRESS IN THE BLOOD OF OSTOMY PATIENTS
title_fullStr INCREASED OXIDATIVE STRESS IN THE BLOOD OF OSTOMY PATIENTS
title_full_unstemmed INCREASED OXIDATIVE STRESS IN THE BLOOD OF OSTOMY PATIENTS
title_sort INCREASED OXIDATIVE STRESS IN THE BLOOD OF OSTOMY PATIENTS
author BAVARESCO,Daniela V
author_facet BAVARESCO,Daniela V
SCHWALM,Mágada T
FARIAS,Beatriz M de
CERETTA,Luciane B
ROSA,Maria Inês da
VALVASSORI,Samira S
author_role author
author2 SCHWALM,Mágada T
FARIAS,Beatriz M de
CERETTA,Luciane B
ROSA,Maria Inês da
VALVASSORI,Samira S
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv BAVARESCO,Daniela V
SCHWALM,Mágada T
FARIAS,Beatriz M de
CERETTA,Luciane B
ROSA,Maria Inês da
VALVASSORI,Samira S
dc.subject.por.fl_str_mv Surgical stomas, adverse effects
Oxidative stress
Lipid peroxidation
Nitration
topic Surgical stomas, adverse effects
Oxidative stress
Lipid peroxidation
Nitration
description ABSTRACT BACKGROUND: Ostomy is a surgical procedure that creates a stoma that aims to construct a new path for the output of feces or urine. The relationship of oxidative stress (OxS) markers in patients with ostomy is still poorly described. OBJECTIVE: The present study was aimed at investigating the changes in oxidative stress parameters in peripheral blood collected from ostomy patients when compared with a healthy control group. METHODS: It was evaluated 29 ostomy patients and 30 healthy control patients. The oxidative stress parameters evaluated were: lipid peroxidation [lipid hydroperoxide (LPO), 8-isoprostane (8-ISO) and 4-hydroxynonenal (4-HNE)], protein oxidation and nitration [carbonyl and 3-nitrotyrosine (3-NT)] and DNA oxidation [8-hydroxy-2’-deoxyguanosine (8-OHDG)] in serum from ostomy patients compared to health controls. RESULTS: The data showed an increase of LPO, 8-ISO, 4-HNE, 3-NT and 8-OHDG in serum collected from ostomy patients when compared to healthy controls. CONCLUSION: The findings support the hypothesis that ostomy triggers the oxidative stress observed in the blood collected from these patients.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032018000200164
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032018000200164
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0004-2803.201800000-29
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
dc.source.none.fl_str_mv Arquivos de Gastroenterologia v.55 n.2 2018
reponame:Arquivos de gastroenterologia (Online)
instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron:IBEPEGE
instname_str Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron_str IBEPEGE
institution IBEPEGE
reponame_str Arquivos de gastroenterologia (Online)
collection Arquivos de gastroenterologia (Online)
repository.name.fl_str_mv Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
repository.mail.fl_str_mv ||secretariaarqgastr@hospitaligesp.com.br
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