Expression of the p53 protein and clinical and pathologic correlation in adenocarcinoma of the rectum

Detalhes bibliográficos
Autor(a) principal: Jurach,Márcia Teresinha
Data de Publicação: 2006
Outros Autores: Meurer,Luise, Moreira,Luis Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de gastroenterologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032006000100006
Resumo: BACKGROUND: p53 is a tumor suppressor gene that has been implicated in the pathogenesis of a wide range of tumors, including colorectal cancer. AIM: To evaluate the prognostic significance of p53 protein expression, and to correlate with clinical and pathologic variables as well as survival. PATIENTS AND METHODS: Immunohistochemical staining for p53 protein was performed in a series of 83 patients with rectal cancer with a follow-up of at least 5 years. RESULTS: Expression of nuclear protein was positive in 36 (43.4%) of the tumors. We found association between positive p53 and death, local recurrence, distant metastasis and overall recurrence and we also found association between p53 and death, local recurrence, metastasis and overall recurrence when analysis was adjusted to Astler-Coller stage and grade of differentiation. CONCLUSION: p53 immunoexpression has shown to be an independent prognostic factor in these series.
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spelling Expression of the p53 protein and clinical and pathologic correlation in adenocarcinoma of the rectumProtein p53Rectal neoplasmsAdenocarcinomaBACKGROUND: p53 is a tumor suppressor gene that has been implicated in the pathogenesis of a wide range of tumors, including colorectal cancer. AIM: To evaluate the prognostic significance of p53 protein expression, and to correlate with clinical and pathologic variables as well as survival. PATIENTS AND METHODS: Immunohistochemical staining for p53 protein was performed in a series of 83 patients with rectal cancer with a follow-up of at least 5 years. RESULTS: Expression of nuclear protein was positive in 36 (43.4%) of the tumors. We found association between positive p53 and death, local recurrence, distant metastasis and overall recurrence and we also found association between p53 and death, local recurrence, metastasis and overall recurrence when analysis was adjusted to Astler-Coller stage and grade of differentiation. CONCLUSION: p53 immunoexpression has shown to be an independent prognostic factor in these series.Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE. 2006-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032006000100006Arquivos de Gastroenterologia v.43 n.1 2006reponame:Arquivos de gastroenterologia (Online)instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiainstacron:IBEPEGE10.1590/S0004-28032006000100006info:eu-repo/semantics/openAccessJurach,Márcia TeresinhaMeurer,LuiseMoreira,Luis Fernandoeng2006-05-08T00:00:00Zoai:scielo:S0004-28032006000100006Revistahttp://www.scielo.br/aghttps://old.scielo.br/oai/scielo-oai.php||secretariaarqgastr@hospitaligesp.com.br1678-42190004-2803opendoar:2006-05-08T00:00Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiafalse
dc.title.none.fl_str_mv Expression of the p53 protein and clinical and pathologic correlation in adenocarcinoma of the rectum
title Expression of the p53 protein and clinical and pathologic correlation in adenocarcinoma of the rectum
spellingShingle Expression of the p53 protein and clinical and pathologic correlation in adenocarcinoma of the rectum
Jurach,Márcia Teresinha
Protein p53
Rectal neoplasms
Adenocarcinoma
title_short Expression of the p53 protein and clinical and pathologic correlation in adenocarcinoma of the rectum
title_full Expression of the p53 protein and clinical and pathologic correlation in adenocarcinoma of the rectum
title_fullStr Expression of the p53 protein and clinical and pathologic correlation in adenocarcinoma of the rectum
title_full_unstemmed Expression of the p53 protein and clinical and pathologic correlation in adenocarcinoma of the rectum
title_sort Expression of the p53 protein and clinical and pathologic correlation in adenocarcinoma of the rectum
author Jurach,Márcia Teresinha
author_facet Jurach,Márcia Teresinha
Meurer,Luise
Moreira,Luis Fernando
author_role author
author2 Meurer,Luise
Moreira,Luis Fernando
author2_role author
author
dc.contributor.author.fl_str_mv Jurach,Márcia Teresinha
Meurer,Luise
Moreira,Luis Fernando
dc.subject.por.fl_str_mv Protein p53
Rectal neoplasms
Adenocarcinoma
topic Protein p53
Rectal neoplasms
Adenocarcinoma
description BACKGROUND: p53 is a tumor suppressor gene that has been implicated in the pathogenesis of a wide range of tumors, including colorectal cancer. AIM: To evaluate the prognostic significance of p53 protein expression, and to correlate with clinical and pathologic variables as well as survival. PATIENTS AND METHODS: Immunohistochemical staining for p53 protein was performed in a series of 83 patients with rectal cancer with a follow-up of at least 5 years. RESULTS: Expression of nuclear protein was positive in 36 (43.4%) of the tumors. We found association between positive p53 and death, local recurrence, distant metastasis and overall recurrence and we also found association between p53 and death, local recurrence, metastasis and overall recurrence when analysis was adjusted to Astler-Coller stage and grade of differentiation. CONCLUSION: p53 immunoexpression has shown to be an independent prognostic factor in these series.
publishDate 2006
dc.date.none.fl_str_mv 2006-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032006000100006
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-28032006000100006
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
dc.source.none.fl_str_mv Arquivos de Gastroenterologia v.43 n.1 2006
reponame:Arquivos de gastroenterologia (Online)
instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron:IBEPEGE
instname_str Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron_str IBEPEGE
institution IBEPEGE
reponame_str Arquivos de gastroenterologia (Online)
collection Arquivos de gastroenterologia (Online)
repository.name.fl_str_mv Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
repository.mail.fl_str_mv ||secretariaarqgastr@hospitaligesp.com.br
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