Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option

Detalhes bibliográficos
Autor(a) principal: Eisig,Jaime Natan
Data de Publicação: 2011
Outros Autores: Silva,Fernando Marcuz, Barbuti,Ricardo Correa, Navarro-Rodriguez,Tomás, Moraes-Filho,Joaquim Prado P, Pedrazzoli Jr,José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de gastroenterologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032011000400008
Resumo: CONTEXT: The antibiotic susceptibility is the cornerstone for the eradication therapies of Helicobacter pylori. OBJECTIVES: To evaluate the prevalence of primary resistance of H. pylori was evaluated in an urban Brazilian population. METHODS:H. pylori isolates were obtained from patients submitted to an upper gastrointestinal endoscopy for the evaluation of dyspeptic symptoms. Biopsies from antrum, corpus and fundus were taken to determine the antibiotic susceptibility of H. pylori isolates. The minimal inhibitory concentration of furazolidone and bismuth were routinely determined by agar dilution method and the minimal inhibitory for amoxicillin, clarithromycin, tetracycline, levofloxacin, and metronidazole were routinely determined with the E-test. RESULTS: Fifty-four patients were included. In vitro antimicrobial susceptibility of H. pylori strains were obtained from 39 patients. Resistance to metronidazole was detected in 20 patients (51%), to clarithromycin in 3 patients (8%), to levofloxacin in 9 patients (23%) and to bismuth in 2 patients (5%). There was no observed resistance to amoxicillin, tetracycline or furazolidone. CONCLUSION: Due to the low amoxicillin and clarithromycin resistance observed in this study, therapies using these antimicrobials remain appropriated first-line H. pylori therapy.
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spelling Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good optionHelicobacter pyloriDrug resistancemicrobialClarithromycinAmoxicillinCONTEXT: The antibiotic susceptibility is the cornerstone for the eradication therapies of Helicobacter pylori. OBJECTIVES: To evaluate the prevalence of primary resistance of H. pylori was evaluated in an urban Brazilian population. METHODS:H. pylori isolates were obtained from patients submitted to an upper gastrointestinal endoscopy for the evaluation of dyspeptic symptoms. Biopsies from antrum, corpus and fundus were taken to determine the antibiotic susceptibility of H. pylori isolates. The minimal inhibitory concentration of furazolidone and bismuth were routinely determined by agar dilution method and the minimal inhibitory for amoxicillin, clarithromycin, tetracycline, levofloxacin, and metronidazole were routinely determined with the E-test. RESULTS: Fifty-four patients were included. In vitro antimicrobial susceptibility of H. pylori strains were obtained from 39 patients. Resistance to metronidazole was detected in 20 patients (51%), to clarithromycin in 3 patients (8%), to levofloxacin in 9 patients (23%) and to bismuth in 2 patients (5%). There was no observed resistance to amoxicillin, tetracycline or furazolidone. CONCLUSION: Due to the low amoxicillin and clarithromycin resistance observed in this study, therapies using these antimicrobials remain appropriated first-line H. pylori therapy.Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE. 2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032011000400008Arquivos de Gastroenterologia v.48 n.4 2011reponame:Arquivos de gastroenterologia (Online)instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiainstacron:IBEPEGE10.1590/S0004-28032011000400008info:eu-repo/semantics/openAccessEisig,Jaime NatanSilva,Fernando MarcuzBarbuti,Ricardo CorreaNavarro-Rodriguez,TomásMoraes-Filho,Joaquim Prado PPedrazzoli Jr,Joséeng2012-03-02T00:00:00Zoai:scielo:S0004-28032011000400008Revistahttp://www.scielo.br/aghttps://old.scielo.br/oai/scielo-oai.php||secretariaarqgastr@hospitaligesp.com.br1678-42190004-2803opendoar:2012-03-02T00:00Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiafalse
dc.title.none.fl_str_mv Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option
title Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option
spellingShingle Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option
Eisig,Jaime Natan
Helicobacter pylori
Drug resistance
microbial
Clarithromycin
Amoxicillin
title_short Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option
title_full Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option
title_fullStr Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option
title_full_unstemmed Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option
title_sort Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option
author Eisig,Jaime Natan
author_facet Eisig,Jaime Natan
Silva,Fernando Marcuz
Barbuti,Ricardo Correa
Navarro-Rodriguez,Tomás
Moraes-Filho,Joaquim Prado P
Pedrazzoli Jr,José
author_role author
author2 Silva,Fernando Marcuz
Barbuti,Ricardo Correa
Navarro-Rodriguez,Tomás
Moraes-Filho,Joaquim Prado P
Pedrazzoli Jr,José
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Eisig,Jaime Natan
Silva,Fernando Marcuz
Barbuti,Ricardo Correa
Navarro-Rodriguez,Tomás
Moraes-Filho,Joaquim Prado P
Pedrazzoli Jr,José
dc.subject.por.fl_str_mv Helicobacter pylori
Drug resistance
microbial
Clarithromycin
Amoxicillin
topic Helicobacter pylori
Drug resistance
microbial
Clarithromycin
Amoxicillin
description CONTEXT: The antibiotic susceptibility is the cornerstone for the eradication therapies of Helicobacter pylori. OBJECTIVES: To evaluate the prevalence of primary resistance of H. pylori was evaluated in an urban Brazilian population. METHODS:H. pylori isolates were obtained from patients submitted to an upper gastrointestinal endoscopy for the evaluation of dyspeptic symptoms. Biopsies from antrum, corpus and fundus were taken to determine the antibiotic susceptibility of H. pylori isolates. The minimal inhibitory concentration of furazolidone and bismuth were routinely determined by agar dilution method and the minimal inhibitory for amoxicillin, clarithromycin, tetracycline, levofloxacin, and metronidazole were routinely determined with the E-test. RESULTS: Fifty-four patients were included. In vitro antimicrobial susceptibility of H. pylori strains were obtained from 39 patients. Resistance to metronidazole was detected in 20 patients (51%), to clarithromycin in 3 patients (8%), to levofloxacin in 9 patients (23%) and to bismuth in 2 patients (5%). There was no observed resistance to amoxicillin, tetracycline or furazolidone. CONCLUSION: Due to the low amoxicillin and clarithromycin resistance observed in this study, therapies using these antimicrobials remain appropriated first-line H. pylori therapy.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032011000400008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032011000400008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-28032011000400008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
dc.source.none.fl_str_mv Arquivos de Gastroenterologia v.48 n.4 2011
reponame:Arquivos de gastroenterologia (Online)
instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron:IBEPEGE
instname_str Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron_str IBEPEGE
institution IBEPEGE
reponame_str Arquivos de gastroenterologia (Online)
collection Arquivos de gastroenterologia (Online)
repository.name.fl_str_mv Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
repository.mail.fl_str_mv ||secretariaarqgastr@hospitaligesp.com.br
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