BILIARY ATRESIA: evaluation on two distinct periods at a reference pediatric service

Detalhes bibliográficos
Autor(a) principal: QUEIROZ,Thais Costa Nascentes
Data de Publicação: 2014
Outros Autores: FERREIRA,Alexandre Rodrigues, FAGUNDES,Eleonora Druve Tavares, ROQUETE,Mariza Leitão Valadares, PENNA,Francisco José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de gastroenterologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032014000100053
Resumo: Context Biliary atresia is a progressive, idiopathic, fibro-obliterative disease of the extrahepatic biliary tree that pre­sents with biliary obstruction exclusively in the neonatal period. Objectives To assess the differences regarding age at referral, age at surgery, duration of propaedeutics and waiting time for surgery between two groups of infants in different periods. Methods Retrospective study of infants diagnosed with biliary atresia on two periods: 1983-1993 and 1998-2011. Results Biliary atresia was diagnosed in 129 infants, being 48 in casuistic I and 81 in casuistic II. The median age at admission was 94 and 60 days, respectively (P = 0.0001). On evaluating patients who had undergone portoenterostomy before 120 days of age, no difference was observed regarding the duration of propaedeutics or waiting time for surgery (P = 0.15), but difference was found when comparing the age at surgery (P = 0.002). Among those infants with no biliary flow and without liver transplantation or death after 18 post-operative months, the estimated probability of survival was 44.6% and 38.7% in casuistics I and II, respectively. In casuistic I, all infants who showed biliary flow were alive during the observation period and, in casuistic II, 80.3% were alive after 7 years of follow-up. Conclusions Even though patients were admitted and treated earlier, it is clear that surgery could be done sooner. Delay in referral and timely propaedeutics were the main contributors.
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spelling BILIARY ATRESIA: evaluation on two distinct periods at a reference pediatric serviceBiliary atresiaHepatic portoenterostomyLiver transplantationPrognosis Context Biliary atresia is a progressive, idiopathic, fibro-obliterative disease of the extrahepatic biliary tree that pre­sents with biliary obstruction exclusively in the neonatal period. Objectives To assess the differences regarding age at referral, age at surgery, duration of propaedeutics and waiting time for surgery between two groups of infants in different periods. Methods Retrospective study of infants diagnosed with biliary atresia on two periods: 1983-1993 and 1998-2011. Results Biliary atresia was diagnosed in 129 infants, being 48 in casuistic I and 81 in casuistic II. The median age at admission was 94 and 60 days, respectively (P = 0.0001). On evaluating patients who had undergone portoenterostomy before 120 days of age, no difference was observed regarding the duration of propaedeutics or waiting time for surgery (P = 0.15), but difference was found when comparing the age at surgery (P = 0.002). Among those infants with no biliary flow and without liver transplantation or death after 18 post-operative months, the estimated probability of survival was 44.6% and 38.7% in casuistics I and II, respectively. In casuistic I, all infants who showed biliary flow were alive during the observation period and, in casuistic II, 80.3% were alive after 7 years of follow-up. Conclusions Even though patients were admitted and treated earlier, it is clear that surgery could be done sooner. Delay in referral and timely propaedeutics were the main contributors. Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE. 2014-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032014000100053Arquivos de Gastroenterologia v.51 n.1 2014reponame:Arquivos de gastroenterologia (Online)instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiainstacron:IBEPEGE10.1590/S0004-28032014000100011info:eu-repo/semantics/openAccessQUEIROZ,Thais Costa NascentesFERREIRA,Alexandre RodriguesFAGUNDES,Eleonora Druve TavaresROQUETE,Mariza Leitão ValadaresPENNA,Francisco Joséeng2014-11-24T00:00:00Zoai:scielo:S0004-28032014000100053Revistahttp://www.scielo.br/aghttps://old.scielo.br/oai/scielo-oai.php||secretariaarqgastr@hospitaligesp.com.br1678-42190004-2803opendoar:2014-11-24T00:00Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiafalse
dc.title.none.fl_str_mv BILIARY ATRESIA: evaluation on two distinct periods at a reference pediatric service
title BILIARY ATRESIA: evaluation on two distinct periods at a reference pediatric service
spellingShingle BILIARY ATRESIA: evaluation on two distinct periods at a reference pediatric service
QUEIROZ,Thais Costa Nascentes
Biliary atresia
Hepatic portoenterostomy
Liver transplantation
Prognosis
title_short BILIARY ATRESIA: evaluation on two distinct periods at a reference pediatric service
title_full BILIARY ATRESIA: evaluation on two distinct periods at a reference pediatric service
title_fullStr BILIARY ATRESIA: evaluation on two distinct periods at a reference pediatric service
title_full_unstemmed BILIARY ATRESIA: evaluation on two distinct periods at a reference pediatric service
title_sort BILIARY ATRESIA: evaluation on two distinct periods at a reference pediatric service
author QUEIROZ,Thais Costa Nascentes
author_facet QUEIROZ,Thais Costa Nascentes
FERREIRA,Alexandre Rodrigues
FAGUNDES,Eleonora Druve Tavares
ROQUETE,Mariza Leitão Valadares
PENNA,Francisco José
author_role author
author2 FERREIRA,Alexandre Rodrigues
FAGUNDES,Eleonora Druve Tavares
ROQUETE,Mariza Leitão Valadares
PENNA,Francisco José
author2_role author
author
author
author
dc.contributor.author.fl_str_mv QUEIROZ,Thais Costa Nascentes
FERREIRA,Alexandre Rodrigues
FAGUNDES,Eleonora Druve Tavares
ROQUETE,Mariza Leitão Valadares
PENNA,Francisco José
dc.subject.por.fl_str_mv Biliary atresia
Hepatic portoenterostomy
Liver transplantation
Prognosis
topic Biliary atresia
Hepatic portoenterostomy
Liver transplantation
Prognosis
description Context Biliary atresia is a progressive, idiopathic, fibro-obliterative disease of the extrahepatic biliary tree that pre­sents with biliary obstruction exclusively in the neonatal period. Objectives To assess the differences regarding age at referral, age at surgery, duration of propaedeutics and waiting time for surgery between two groups of infants in different periods. Methods Retrospective study of infants diagnosed with biliary atresia on two periods: 1983-1993 and 1998-2011. Results Biliary atresia was diagnosed in 129 infants, being 48 in casuistic I and 81 in casuistic II. The median age at admission was 94 and 60 days, respectively (P = 0.0001). On evaluating patients who had undergone portoenterostomy before 120 days of age, no difference was observed regarding the duration of propaedeutics or waiting time for surgery (P = 0.15), but difference was found when comparing the age at surgery (P = 0.002). Among those infants with no biliary flow and without liver transplantation or death after 18 post-operative months, the estimated probability of survival was 44.6% and 38.7% in casuistics I and II, respectively. In casuistic I, all infants who showed biliary flow were alive during the observation period and, in casuistic II, 80.3% were alive after 7 years of follow-up. Conclusions Even though patients were admitted and treated earlier, it is clear that surgery could be done sooner. Delay in referral and timely propaedeutics were the main contributors.
publishDate 2014
dc.date.none.fl_str_mv 2014-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032014000100053
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032014000100053
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-28032014000100011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
dc.source.none.fl_str_mv Arquivos de Gastroenterologia v.51 n.1 2014
reponame:Arquivos de gastroenterologia (Online)
instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron:IBEPEGE
instname_str Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron_str IBEPEGE
institution IBEPEGE
reponame_str Arquivos de gastroenterologia (Online)
collection Arquivos de gastroenterologia (Online)
repository.name.fl_str_mv Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
repository.mail.fl_str_mv ||secretariaarqgastr@hospitaligesp.com.br
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