Serum levels of vitamin d and hepatic changes in patients with malaria in the Amazon region

• Autor(a) principal: Setto, Janaina Maria
• Data de Publicação: 2023
• Outros Autores: Libonati, Rosana Maria Feio, Ventura, Ana Maria Revoredo da Silva, Chaves, Tânia do Socorro Souza, Sequeira, Carina Guilhon, Martins Filho, Arnaldo Jorge
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Baiana de Saúde Pública (Online)
• Texto Completo: https://rbsp.sesab.ba.gov.br/index.php/rbsp/article/view/3589
• topic: Malária; Testes de função hepática; Vitamina D; Malaria; Pruebas de función hepática; Vitamina D; Malaria; Liver function tests; Vitamin D

Several studies suggest the importance of vitamin D – 25(OH)D – in the clinical evolution of patients with malaria. However, the prevalence of 25(OH)D deficiency in the Amazonian population is little known, and studies with patients diagnosed with malaria are scarce. Thus the objective of this study is to evaluate the serum levels of 25(OH)D in patients with malaria and its relationship with epidemiological and parasitological data and liver function tests. To that end, an analytical cross-sectional study was carried out with a group of patients with malaria and a control group in the municipality of Itaituba (PA), Brazil, from January 2018 to October 2019. A protocol was elaborated for the evaluation of sociodemographic, parasitological, and laboratory data, adopting a significance level of 5%. Results: The prevalence of 25(OH)D deficiency was observed in patients with malaria (28.5%) and in the control group (24.6%), with no statistical difference; however, among residents in the mining, serum levels were statistically lower in patients with malaria. The glutamic-pyruvic transaminase (GPT) serum levels showed an inverse correlation with 25(OH)D levels. Liver function tests were significantly higher in the malaria group. Thus, this study evidenced 25(OH)D deficiency in Itaituba. Hepatic changes due to plasmodial infection may have contributed to the inverse correlation observed between GPT and 25(OH)D levels.