Concentration of serum evaluation resistin in obese young adults: a cross study

• Autor(a) principal: Bonadeo, Jaí­ne
• Data de Publicação: 2015
• Outros Autores: Vogt, Josiele, Ottobelli Chielle, Eduardo
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista brasileira de obesidade, nutrição e emagrecimento
• Texto Completo: https://www.rbone.com.br/index.php/rbone/article/view/388
• topic: Resistin; Diabetes; Glucose; Obesity; Resistir; Diabetes; Glucosa; Obesidad; Resistere; Diabete; Glucosio; Obesità; Resistina; Diabetes; Glicose; Obesidade; Resistina; Diabetes; Glicose; Obesidade

Resistinis a protein produced by adipocytes and macrophages is associated with the development of insulin resistance (IR) and T2DM, and has been demonstrated that this protein is an antagonist of insulin. The objective of this study was to evaluate serum resistin, glucose, HbA1c, insulin in young adults, obese, overweight and normal weight. A cross-sectional study comparing baseline levels of resistin and biochemical parameters were evaluated. 149 young adults were involved in this study, 54 normal weight (18 to 24.9 kg/m2), 27 overweight (25-29.9 kg/m2) and 68 obese (BMI ≥ 30 kg/m2). Obese patients showed resistinlevels, glucose, HbA1c, insulin, and HOMA significantly higher when compared with normal weight patients, and showed significantly reduced insulin sensitivity. Increased production of resistin in obese young adults may be a major factor in the developmentof the inflammatory process and hence RI and DM2 in this population. However, you need larger studies to clarify the exact mechanisms of action of this adipokine in the obese population.