Loss of toxicity by Pseudanabaena galeata in culture
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Hoehnea |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2236-89062017000200269 |
Resumo: | ABSTRACT Pseudanabaena galeata, a well-known toxin-producer, is commonly found in water supplies. In order to assess potential risks associated with oral exposure to this cyanobacterium, mouse toxicological studies were carried out with the monoespecific strain P. galeata CCIBt 3082, which has been kept in culture since 1996. In our studies, the acute oral lethal dose has been estimated to be 5,000 mg kg-1 bw and, in the oral sub-chronic assays, the animals showed a decrease in weight and presented microscopic intestinal lesions, results that did not correspond to statements by other authors. In their studies, oral administration of the extract, whose acute lethal dose has been established to be 1,000 mg kg-1 bw, led to severe intoxication and promoted hepatic and renal lesions. Toxicity loss of this strain may be the result of reductive evolution that can occur in organisms that remain in static environments for long periods. |
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Loss of toxicity by Pseudanabaena galeata in cultureadaptive processchanges in culturecyanobacteriatoxicity lossABSTRACT Pseudanabaena galeata, a well-known toxin-producer, is commonly found in water supplies. In order to assess potential risks associated with oral exposure to this cyanobacterium, mouse toxicological studies were carried out with the monoespecific strain P. galeata CCIBt 3082, which has been kept in culture since 1996. In our studies, the acute oral lethal dose has been estimated to be 5,000 mg kg-1 bw and, in the oral sub-chronic assays, the animals showed a decrease in weight and presented microscopic intestinal lesions, results that did not correspond to statements by other authors. In their studies, oral administration of the extract, whose acute lethal dose has been established to be 1,000 mg kg-1 bw, led to severe intoxication and promoted hepatic and renal lesions. Toxicity loss of this strain may be the result of reductive evolution that can occur in organisms that remain in static environments for long periods.Instituto de Pesquisas Ambientais2017-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2236-89062017000200269Hoehnea v.44 n.2 2017reponame:Hoehneainstname:Instituto de Botânica (IBT)instacron:IBT10.1590/2236-8906-53/2016info:eu-repo/semantics/openAccessGarcia,Angelica NunesPipole,FernandoCunha,Luciana Castro daElias,FabianaGórniak,Silvana LimaSant'Anna,Célia LeiteCarvalho,Luciana Retz deeng2017-06-08T00:00:00Zoai:scielo:S2236-89062017000200269Revistahttp://www.ibot.sp.gov.br/publicacoes/hoehnea/sobre_hoehnea.phpPUBhttps://old.scielo.br/oai/scielo-oai.php||hoehneaibt@gmail.com2236-89060073-2877opendoar:2017-06-08T00:00Hoehnea - Instituto de Botânica (IBT)false |
dc.title.none.fl_str_mv |
Loss of toxicity by Pseudanabaena galeata in culture |
title |
Loss of toxicity by Pseudanabaena galeata in culture |
spellingShingle |
Loss of toxicity by Pseudanabaena galeata in culture Garcia,Angelica Nunes adaptive process changes in culture cyanobacteria toxicity loss |
title_short |
Loss of toxicity by Pseudanabaena galeata in culture |
title_full |
Loss of toxicity by Pseudanabaena galeata in culture |
title_fullStr |
Loss of toxicity by Pseudanabaena galeata in culture |
title_full_unstemmed |
Loss of toxicity by Pseudanabaena galeata in culture |
title_sort |
Loss of toxicity by Pseudanabaena galeata in culture |
author |
Garcia,Angelica Nunes |
author_facet |
Garcia,Angelica Nunes Pipole,Fernando Cunha,Luciana Castro da Elias,Fabiana Górniak,Silvana Lima Sant'Anna,Célia Leite Carvalho,Luciana Retz de |
author_role |
author |
author2 |
Pipole,Fernando Cunha,Luciana Castro da Elias,Fabiana Górniak,Silvana Lima Sant'Anna,Célia Leite Carvalho,Luciana Retz de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Garcia,Angelica Nunes Pipole,Fernando Cunha,Luciana Castro da Elias,Fabiana Górniak,Silvana Lima Sant'Anna,Célia Leite Carvalho,Luciana Retz de |
dc.subject.por.fl_str_mv |
adaptive process changes in culture cyanobacteria toxicity loss |
topic |
adaptive process changes in culture cyanobacteria toxicity loss |
description |
ABSTRACT Pseudanabaena galeata, a well-known toxin-producer, is commonly found in water supplies. In order to assess potential risks associated with oral exposure to this cyanobacterium, mouse toxicological studies were carried out with the monoespecific strain P. galeata CCIBt 3082, which has been kept in culture since 1996. In our studies, the acute oral lethal dose has been estimated to be 5,000 mg kg-1 bw and, in the oral sub-chronic assays, the animals showed a decrease in weight and presented microscopic intestinal lesions, results that did not correspond to statements by other authors. In their studies, oral administration of the extract, whose acute lethal dose has been established to be 1,000 mg kg-1 bw, led to severe intoxication and promoted hepatic and renal lesions. Toxicity loss of this strain may be the result of reductive evolution that can occur in organisms that remain in static environments for long periods. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2236-89062017000200269 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2236-89062017000200269 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2236-8906-53/2016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Pesquisas Ambientais |
publisher.none.fl_str_mv |
Instituto de Pesquisas Ambientais |
dc.source.none.fl_str_mv |
Hoehnea v.44 n.2 2017 reponame:Hoehnea instname:Instituto de Botânica (IBT) instacron:IBT |
instname_str |
Instituto de Botânica (IBT) |
instacron_str |
IBT |
institution |
IBT |
reponame_str |
Hoehnea |
collection |
Hoehnea |
repository.name.fl_str_mv |
Hoehnea - Instituto de Botânica (IBT) |
repository.mail.fl_str_mv |
||hoehneaibt@gmail.com |
_version_ |
1754193647586246656 |