Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/2443 |
Resumo: | Introduction: Due to the importance that howler monkeys have on the yellow fever (YF) epidemiological sylvatic cycle in Brazil, more accurate morphological diagnostic criteria needs to be established, especially considering the differences that may exist between the genera of Brazilian non-human primates (NHPs) involved in yellow fever virus (YFV) epizootics. Methods: Records of YF epizootics in NHPs in Brazil between 2007 and 2009 were obtained from the Brazilian Ministry of Health database to select YF positive (n=98) Howler monkeys (Alouatta sp.) for this study. The changes described in the histopathological reports were categorized by organ and their frequencies calculated. Results: The most frequent lesions observed in the animals with YF were hepatocyte apoptosis (Councilman body formation), midzonal hepatocyte necrosis, steatosis, liver hemorrhage, infl ammatory mononuclear cell infi ltration of the liver, renal acute tubular necrosis and interstitial nephritis. Midzonal hepatocyte necrosis, steatosis and hemorrhage presented positive correlations with apoptosis of hepatocytes, suggesting strong YFV pathogenic effect association; they were also the main histopathological changes in the Alouatta sp. A pronounced negative correlation between apoptosis of hepatocytes and hepatic mononuclear cell infi ltration pointed to signifi cant histopathological differences between YFV infection in Howler monkeys and humans. Conclusions: The results warn that NHPs may exhibit different response patterns following YFV infection and require a more careful diagnosis. Presumptive diagnosis based on primate histopathological lesions may contribute to public health service control. |
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Leal, Silvana GomesRomano, Alessandro Pecego MartinsMonteiro, Rafael VeríssimoMelo, Cristiano Barros deVasconcelos, Pedro Fernando da CostaCastro, Márcio Botelho de2017-01-30T15:07:57Z2017-01-30T15:07:57Z2016LEAL, Silvana Gomes et al. Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 49, n. 1, p. 29-33, Jan.-Feb. 2016.1678-9849https://patua.iec.gov.br/handle/iec/244310.1590/0037-8682-0363-2015Introduction: Due to the importance that howler monkeys have on the yellow fever (YF) epidemiological sylvatic cycle in Brazil, more accurate morphological diagnostic criteria needs to be established, especially considering the differences that may exist between the genera of Brazilian non-human primates (NHPs) involved in yellow fever virus (YFV) epizootics. Methods: Records of YF epizootics in NHPs in Brazil between 2007 and 2009 were obtained from the Brazilian Ministry of Health database to select YF positive (n=98) Howler monkeys (Alouatta sp.) for this study. The changes described in the histopathological reports were categorized by organ and their frequencies calculated. Results: The most frequent lesions observed in the animals with YF were hepatocyte apoptosis (Councilman body formation), midzonal hepatocyte necrosis, steatosis, liver hemorrhage, infl ammatory mononuclear cell infi ltration of the liver, renal acute tubular necrosis and interstitial nephritis. Midzonal hepatocyte necrosis, steatosis and hemorrhage presented positive correlations with apoptosis of hepatocytes, suggesting strong YFV pathogenic effect association; they were also the main histopathological changes in the Alouatta sp. A pronounced negative correlation between apoptosis of hepatocytes and hepatic mononuclear cell infi ltration pointed to signifi cant histopathological differences between YFV infection in Howler monkeys and humans. Conclusions: The results warn that NHPs may exhibit different response patterns following YFV infection and require a more careful diagnosis. Presumptive diagnosis based on primate histopathological lesions may contribute to public health service control.Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Brasília, DF, Brasil.Universidade de Brasília. Faculdade de Agronomia e Veterinária. Brasília, DF, Brasil.Universidade de Brasília. Faculdade de Agronomia e Veterinária. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade de Brasília. Faculdade de Agronomia e Veterinária. Brasília, DF, Brasil.application/pdfengSociedade Brasileira de Medicina TropicalFrequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in BrazilFrequência de alterações histopatológicas em macacos-macacos (Alouatta sp.) Infectados naturalmente com o vírus da febre amarela no Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20072009Febre Amarela / veterináriaVírus da Febre Amarela / patogenicidadeAlouatta / virologiaDoenças dos MacacosEspecificidade da EspécieBrasil (BR)info:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECTHUMBNAILFrequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil.pdf.jpgFrequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil.pdf.jpgGenerated Thumbnailimage/jpeg6664https://patua.iec.gov.br/bitstreams/b5fdfb7c-6d27-414d-a4b5-3e08f6b72689/download8ca0478aede0ce4009ab61bfed6700b8MD57ORIGINALFrequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil.pdfapplication/pdf3157511https://patua.iec.gov.br/bitstreams/ff151909-7a1a-4159-9c3b-784f2f29d514/downloadedaefce0c578aaa90a92ec2e94112947MD51TEXTFrequency of histopathological changes in Howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil.pdf.txtFrequency of histopathological changes in Howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil.pdf.txtExtracted texttext/plain21887https://patua.iec.gov.br/bitstreams/e7ec238e-a88b-40f0-a0a9-20dbde299249/download9012af07e645bb81ef3ab92a1a0168d1MD52Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil.pdf.txtFrequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil.pdf.txtExtracted texttext/plain21988https://patua.iec.gov.br/bitstreams/fef01c1f-a78a-47f8-b367-3a22b2784e66/downloaddfcbb0c81ebfbffda8cf9d5a736bdc93MD56LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil |
dc.title.alternative.pt_BR.fl_str_mv |
Frequência de alterações histopatológicas em macacos-macacos (Alouatta sp.) Infectados naturalmente com o vírus da febre amarela no Brasil |
title |
Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil |
spellingShingle |
Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil Leal, Silvana Gomes Febre Amarela / veterinária Vírus da Febre Amarela / patogenicidade Alouatta / virologia Doenças dos Macacos Especificidade da Espécie Brasil (BR) |
title_short |
Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil |
title_full |
Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil |
title_fullStr |
Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil |
title_full_unstemmed |
Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil |
title_sort |
Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil |
author |
Leal, Silvana Gomes |
author_facet |
Leal, Silvana Gomes Romano, Alessandro Pecego Martins Monteiro, Rafael Veríssimo Melo, Cristiano Barros de Vasconcelos, Pedro Fernando da Costa Castro, Márcio Botelho de |
author_role |
author |
author2 |
Romano, Alessandro Pecego Martins Monteiro, Rafael Veríssimo Melo, Cristiano Barros de Vasconcelos, Pedro Fernando da Costa Castro, Márcio Botelho de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Leal, Silvana Gomes Romano, Alessandro Pecego Martins Monteiro, Rafael Veríssimo Melo, Cristiano Barros de Vasconcelos, Pedro Fernando da Costa Castro, Márcio Botelho de |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Febre Amarela / veterinária Vírus da Febre Amarela / patogenicidade Alouatta / virologia Doenças dos Macacos Especificidade da Espécie Brasil (BR) |
topic |
Febre Amarela / veterinária Vírus da Febre Amarela / patogenicidade Alouatta / virologia Doenças dos Macacos Especificidade da Espécie Brasil (BR) |
description |
Introduction: Due to the importance that howler monkeys have on the yellow fever (YF) epidemiological sylvatic cycle in Brazil, more accurate morphological diagnostic criteria needs to be established, especially considering the differences that may exist between the genera of Brazilian non-human primates (NHPs) involved in yellow fever virus (YFV) epizootics. Methods: Records of YF epizootics in NHPs in Brazil between 2007 and 2009 were obtained from the Brazilian Ministry of Health database to select YF positive (n=98) Howler monkeys (Alouatta sp.) for this study. The changes described in the histopathological reports were categorized by organ and their frequencies calculated. Results: The most frequent lesions observed in the animals with YF were hepatocyte apoptosis (Councilman body formation), midzonal hepatocyte necrosis, steatosis, liver hemorrhage, infl ammatory mononuclear cell infi ltration of the liver, renal acute tubular necrosis and interstitial nephritis. Midzonal hepatocyte necrosis, steatosis and hemorrhage presented positive correlations with apoptosis of hepatocytes, suggesting strong YFV pathogenic effect association; they were also the main histopathological changes in the Alouatta sp. A pronounced negative correlation between apoptosis of hepatocytes and hepatic mononuclear cell infi ltration pointed to signifi cant histopathological differences between YFV infection in Howler monkeys and humans. Conclusions: The results warn that NHPs may exhibit different response patterns following YFV infection and require a more careful diagnosis. Presumptive diagnosis based on primate histopathological lesions may contribute to public health service control. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-01-30T15:07:57Z |
dc.date.available.fl_str_mv |
2017-01-30T15:07:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LEAL, Silvana Gomes et al. Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 49, n. 1, p. 29-33, Jan.-Feb. 2016. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/2443 |
dc.identifier.issn.-.fl_str_mv |
1678-9849 |
dc.identifier.doi.-.fl_str_mv |
10.1590/0037-8682-0363-2015 |
identifier_str_mv |
LEAL, Silvana Gomes et al. Frequency of histopathological changes in howler monkeys (Alouatta sp.) naturally infected with yellow fever virus in Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 49, n. 1, p. 29-33, Jan.-Feb. 2016. 1678-9849 10.1590/0037-8682-0363-2015 |
url |
https://patua.iec.gov.br/handle/iec/2443 |
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eng |
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eng |
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Sociedade Brasileira de Medicina Tropical |
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Sociedade Brasileira de Medicina Tropical |
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