A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis

Detalhes bibliográficos
Autor(a) principal: De Vos, Beatrice
Data de Publicação: 2004
Outros Autores: Vesikari, Timo, Linhares, Alexandre da Costa, Salinas, Belén, Pérez-Schael, Irene, Ruiz-Palacios, Guillermo M, Guerrero, Maria de Lourdes, Phua, Kong Boo, Delem, Andrée, Hardt, Karin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
DOI: 10.1097/01.inf.0000142370.16514.4a
Texto Completo: https://patua.iec.gov.br/handle/iec/3248
Resumo: The need for safe and efective vaccines to reduce morbidity and mortality caused by rotavirus gastroenteritis in children is weel-known. A live attenuated monovalent ratavirus vaccine (Rotarix) containing human rotavirus strain RIX4414 of G1P1A P[8] specificity is being developed to meet the global need. An overview of RIX4414 trials in developed and developing sttings is presented for 3 selected trials conducted in Finland (pilot study), Latin America (Brazil, Mexico and venezuela) and Singapore involving 5024 infants. The vaccine was well-tolerte, with no increase in any solicited symptoms as compared with the placebo. After 2 doses, 61-91 per cent of vaccineted infants developed rotavirus-specific IgA antibodies. There was no interference with immunogenicity of coadministere routine pediatric vaccines. Rotarix significantly reduced rotavirus gastroenteritis episodes and rotavirus related hospitalizations in vaccinated infants compared wiyh placebo recipients (p0.05), Vaccine efficacy was observed against severe rotavirus gastroenteritis caused by G1 and non-G1 types including the emerging G9 tyoe (p0.05) in Latin America. these results show prospects for widespread us of Rotarix to reduce raotavieus disease burden ans warrant continued worldwide evaluation.
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spelling De Vos, BeatriceVesikari, TimoLinhares, Alexandre da CostaSalinas, BelénPérez-Schael, IreneRuiz-Palacios, Guillermo MGuerrero, Maria de LourdesPhua, Kong BooDelem, AndréeHardt, Karin2018-07-17T14:14:44Z2018-07-17T14:14:44Z2004DE VOS, Beatrice et al. A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis. Pediatric Infectious Disease Journal, v. 23, n. 10, p. S179-S182, Oct. 2004.0891-3668https://patua.iec.gov.br/handle/iec/324810.1097/01.inf.0000142370.16514.4aThe need for safe and efective vaccines to reduce morbidity and mortality caused by rotavirus gastroenteritis in children is weel-known. A live attenuated monovalent ratavirus vaccine (Rotarix) containing human rotavirus strain RIX4414 of G1P1A P[8] specificity is being developed to meet the global need. An overview of RIX4414 trials in developed and developing sttings is presented for 3 selected trials conducted in Finland (pilot study), Latin America (Brazil, Mexico and venezuela) and Singapore involving 5024 infants. The vaccine was well-tolerte, with no increase in any solicited symptoms as compared with the placebo. After 2 doses, 61-91 per cent of vaccineted infants developed rotavirus-specific IgA antibodies. There was no interference with immunogenicity of coadministere routine pediatric vaccines. Rotarix significantly reduced rotavirus gastroenteritis episodes and rotavirus related hospitalizations in vaccinated infants compared wiyh placebo recipients (p0.05), Vaccine efficacy was observed against severe rotavirus gastroenteritis caused by G1 and non-G1 types including the emerging G9 tyoe (p0.05) in Latin America. these results show prospects for widespread us of Rotarix to reduce raotavieus disease burden ans warrant continued worldwide evaluation.Glaxo SmithKline Biologicals. Rixensart, Belgium.University of Tampere. Medical School. Tampere, Finland.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Universidad de Carabobo. Dr. Enrique Tejera. Ciudad Hospitalaria. Insalud, Valencia, Venezuela.Universidad Central de Venezuela. Instituto de Biomedicina. Caracas, Venezuela.Instituto Nacional de Ciencias Medicas y Nutricion. Mexico.Instituto Nacional de Ciencias Medicas y Nutricion. Mexico.KK Women’s and Children’s Hospital. Singapore.Glaxo SmithKline Biologicals. Rixensart, Belgium.Glaxo SmithKline Biologicals. Rixensart, Belgium.engLippincott, Williams & WilkinsA rotavirus vaccine for prophylaxis against rotavirus gastroenteritisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGastroenterite / virologiaInfecções por Rotavirus / quimioterapiaInfecções por Rotavirus / prevenção & controleVacinas contra Rotavirus / uso terapêuticoVacinas contra Rotavirus / administração & dosageminfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALA rotavirus vaccine for prophylaxis against rotavirus gastroenteritis.pdfA rotavirus vaccine for prophylaxis against rotavirus gastroenteritis.pdfapplication/pdf169086https://patua.iec.gov.br/bitstreams/41ae862d-84ff-4403-bab7-76d15e02c245/downloadb3d71bbdbfde7442bbafbaeb58c44337MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/6232904d-9ce6-4517-a8b1-e4d2a28a2f39/download52f1732ea66fbd1123abe39f5373b797MD52TEXTA rotavirus vaccine for prophylaxis against rotavirus gastroenteritis.pdf.txtA rotavirus vaccine for prophylaxis against rotavirus gastroenteritis.pdf.txtExtracted texttext/plain25057https://patua.iec.gov.br/bitstreams/abb2f204-cb98-4ad8-98f1-137f2a460aa5/download52323c02e851eb7dcf6d96d840c2ccb9MD55THUMBNAILA rotavirus vaccine for prophylaxis against rotavirus gastroenteritis.pdf.jpgA rotavirus vaccine for prophylaxis against rotavirus gastroenteritis.pdf.jpgGenerated Thumbnailimage/jpeg6269https://patua.iec.gov.br/bitstreams/7083635c-ccfa-4724-aff6-a5cda128136b/download25b83bcef769ac2dc9ac4f553d201671MD56iec/32482022-10-21 00:37:56.698oai:patua.iec.gov.br:iec/3248https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-21T00:37:56Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4=
dc.title.pt_BR.fl_str_mv A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis
title A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis
spellingShingle A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis
A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis
De Vos, Beatrice
Gastroenterite / virologia
Infecções por Rotavirus / quimioterapia
Infecções por Rotavirus / prevenção & controle
Vacinas contra Rotavirus / uso terapêutico
Vacinas contra Rotavirus / administração & dosagem
De Vos, Beatrice
Gastroenterite / virologia
Infecções por Rotavirus / quimioterapia
Infecções por Rotavirus / prevenção & controle
Vacinas contra Rotavirus / uso terapêutico
Vacinas contra Rotavirus / administração & dosagem
title_short A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis
title_full A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis
title_fullStr A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis
A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis
title_full_unstemmed A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis
A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis
title_sort A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis
author De Vos, Beatrice
author_facet De Vos, Beatrice
De Vos, Beatrice
Vesikari, Timo
Linhares, Alexandre da Costa
Salinas, Belén
Pérez-Schael, Irene
Ruiz-Palacios, Guillermo M
Guerrero, Maria de Lourdes
Phua, Kong Boo
Delem, Andrée
Hardt, Karin
Vesikari, Timo
Linhares, Alexandre da Costa
Salinas, Belén
Pérez-Schael, Irene
Ruiz-Palacios, Guillermo M
Guerrero, Maria de Lourdes
Phua, Kong Boo
Delem, Andrée
Hardt, Karin
author_role author
author2 Vesikari, Timo
Linhares, Alexandre da Costa
Salinas, Belén
Pérez-Schael, Irene
Ruiz-Palacios, Guillermo M
Guerrero, Maria de Lourdes
Phua, Kong Boo
Delem, Andrée
Hardt, Karin
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv De Vos, Beatrice
Vesikari, Timo
Linhares, Alexandre da Costa
Salinas, Belén
Pérez-Schael, Irene
Ruiz-Palacios, Guillermo M
Guerrero, Maria de Lourdes
Phua, Kong Boo
Delem, Andrée
Hardt, Karin
dc.subject.decsPrimary.pt_BR.fl_str_mv Gastroenterite / virologia
Infecções por Rotavirus / quimioterapia
Infecções por Rotavirus / prevenção & controle
Vacinas contra Rotavirus / uso terapêutico
Vacinas contra Rotavirus / administração & dosagem
topic Gastroenterite / virologia
Infecções por Rotavirus / quimioterapia
Infecções por Rotavirus / prevenção & controle
Vacinas contra Rotavirus / uso terapêutico
Vacinas contra Rotavirus / administração & dosagem
description The need for safe and efective vaccines to reduce morbidity and mortality caused by rotavirus gastroenteritis in children is weel-known. A live attenuated monovalent ratavirus vaccine (Rotarix) containing human rotavirus strain RIX4414 of G1P1A P[8] specificity is being developed to meet the global need. An overview of RIX4414 trials in developed and developing sttings is presented for 3 selected trials conducted in Finland (pilot study), Latin America (Brazil, Mexico and venezuela) and Singapore involving 5024 infants. The vaccine was well-tolerte, with no increase in any solicited symptoms as compared with the placebo. After 2 doses, 61-91 per cent of vaccineted infants developed rotavirus-specific IgA antibodies. There was no interference with immunogenicity of coadministere routine pediatric vaccines. Rotarix significantly reduced rotavirus gastroenteritis episodes and rotavirus related hospitalizations in vaccinated infants compared wiyh placebo recipients (p0.05), Vaccine efficacy was observed against severe rotavirus gastroenteritis caused by G1 and non-G1 types including the emerging G9 tyoe (p0.05) in Latin America. these results show prospects for widespread us of Rotarix to reduce raotavieus disease burden ans warrant continued worldwide evaluation.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2018-07-17T14:14:44Z
dc.date.available.fl_str_mv 2018-07-17T14:14:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv DE VOS, Beatrice et al. A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis. Pediatric Infectious Disease Journal, v. 23, n. 10, p. S179-S182, Oct. 2004.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/3248
dc.identifier.issn.-.fl_str_mv 0891-3668
dc.identifier.doi.-.fl_str_mv 10.1097/01.inf.0000142370.16514.4a
identifier_str_mv DE VOS, Beatrice et al. A rotavirus vaccine for prophylaxis against rotavirus gastroenteritis. Pediatric Infectious Disease Journal, v. 23, n. 10, p. S179-S182, Oct. 2004.
0891-3668
10.1097/01.inf.0000142370.16514.4a
url https://patua.iec.gov.br/handle/iec/3248
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
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reponame_str Repositório Digital do Instituto Evandro Chagas (Patuá)
collection Repositório Digital do Instituto Evandro Chagas (Patuá)
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