Characterization of Triniti virus supports its reclassification in the family Peribunyaviridae

• Autor(a) principal: Lima, Juliana Abreu
• Data de Publicação: 2019
• Outros Autores: Nunes Neto, Joaquim Pinto, Castro, Karoline Silva, Rosa, Amélia Paes de Andrade Travassos da, Tesh, Robert B, Nunes, Márcio Roberto Teixeira, Popov, Vsevolod Leonidovich, Vasilakis, Nikos, Guzman, Hilda, Widen, Steven, Silva, Sandro Patroca da, Medeiros, Daniele Barbosa de Almeida, Cardoso, Jedson Ferreira, Martins, Lívia Caricio, Azevedo, Raimunda do Socorro da Silva, Vasconcelos, Pedro Fernando da Costa, Chiang, Jannifer Oliveira
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/3596
• topic: Bunyaviridae / classificação; Vírus Triniti; Arbovirus / classificação; Testes Sorológicos / métodos; Análise Citogenética

Triniti virus (TNTV) has been isolated in Trinidad and Tobago and in Brazil. To date little is known about this virus, which is classified as an ungrouped virus within the family Togaviridae. Here, three isolates of TNTV were characterized both genetically and antigenically. The genome was shown to contain three RNA segments: small (S), medium (M) and large (L). Genome organization, protein sizes and protein motifs were similar to those of viruses in the genus Orthobunyavirus, family Peribunyaviridae. Antigenic reactivity revealed the three TNTV isolates to be closely related, but no serologic cross-reaction with other orthobunyaviruses. Morphological observation by transmission electron microscopy indicated that virus size and symmetry were compatible with those of viruses in the family Peribunyaviridae. Our serological, morphological and molecular results support the taxonomic reclassification of TNTV as a member of the genus Orthobunyavirus, family Peribunyaviridae.