Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4170 |
Resumo: | Background/Aim: Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, with different clinical features. The aim of the study was to perform a microarray-based analysis in two groups of patients (<45 and ≥45 years old), in order to verify the occurrence of specific copy number alterations (CNAs) that could be associated to different patient behaviors associated with age. Patients and Methods: In order to search and compare genomic alterations that may be related to age, we evaluated the occurrence of CNAs in the genome of 24 PTC samples, divided in two groups (<45 and ≥45 years old). Results: We identified only one region showing a statistically significant difference between the groups (p=0.00357): a deletion of approximately 537 kps in 1p35.3., which was more frequent in patients aged 45 years or older. This is the region where, among others, the gene SESN2 is located, which is activated under oxidative stress and plays an antioxidant role, in addition to protecting the genetic material from damage generated by reactive oxygen species (ROS). Conclusion: This is the first time that a CNA involving the deletion of the SESN2 gene is associated with papillary thyroid carcinomas, particularly in patients aged 45 years and older, indicating that this deletion would lead to a more malignant and prominent tumoral behavior associated to a worst prognosis. |
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Almeida, Deise Cibele N. deSouza, Michel Platini Caldas deAmorim, Carolina Koury NassarMaués, Jersey Heitor da SilvaSagica, Fernanda do Espírito SantoNunes, Caroline Aquino MoreiraOliveria, Edivaldo Herculano Corrêa de2020-09-15T16:15:22Z2020-09-15T16:15:22Z2020ALMEIDA, Deise Cibele N. de et al. Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?. Cancer Genomics and Proteomics, v. 17, n. 5, p. 643-648, Sept./Oct. 2020. DOI: https://doi.org/10.21873/cgp.20220. Disponível em: https://cgp.iiarjournals.org/content/cgp/17/5/643.full.pdf.1790-6245https://patua.iec.gov.br/handle/iec/417010.21873/cgp.20220Background/Aim: Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, with different clinical features. The aim of the study was to perform a microarray-based analysis in two groups of patients (<45 and ≥45 years old), in order to verify the occurrence of specific copy number alterations (CNAs) that could be associated to different patient behaviors associated with age. Patients and Methods: In order to search and compare genomic alterations that may be related to age, we evaluated the occurrence of CNAs in the genome of 24 PTC samples, divided in two groups (<45 and ≥45 years old). Results: We identified only one region showing a statistically significant difference between the groups (p=0.00357): a deletion of approximately 537 kps in 1p35.3., which was more frequent in patients aged 45 years or older. This is the region where, among others, the gene SESN2 is located, which is activated under oxidative stress and plays an antioxidant role, in addition to protecting the genetic material from damage generated by reactive oxygen species (ROS). Conclusion: This is the first time that a CNA involving the deletion of the SESN2 gene is associated with papillary thyroid carcinomas, particularly in patients aged 45 years and older, indicating that this deletion would lead to a more malignant and prominent tumoral behavior associated to a worst prognosis.This study was partially supported by the Ministry of Health through the Evandro Chagas Institute official budget and by CNPq (process 307382/2019-2)Federal University of Pará. Institute of Biological Sciences. Neuroscience and Cell Biology Pos-Graduation Program. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Cultura de Tecidos e Citogenética. Ananindeua, PA, Brasil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Human Cytogenetics. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Cultura de Tecidos e Citogenética. Ananindeua, PA, Brasil.Federal University of Ceará. Drug Research and Development Center. Pharmacogenetics Laboratory. Fortaleza, CE, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Cultura de Tecidos e Citogenética. Ananindeua, PA, Brasil / Federal University of Pará. Institute of Exact and Natural Sciences. Belém, PA, Brazil.engInternational Institute of Anticancer ResearchCopy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNeoplasias / diagnósticoNeoplasias da Glândula Tireoide / diagnósticoCâncer Papilífero da TireoideEstresse Oxidativo / genéticaIdoso / fisiologiaEnvelhecimentoinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALCopy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?.pdfCopy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?.pdfapplication/pdf2136580https://patua.iec.gov.br/bitstreams/5a160fe1-5186-4cd3-b3c7-2c55467d656b/downloaddf9be0648ce4e14ab07c3a709279ddcdMD51TEXTCopy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?.pdf.txtCopy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?.pdf.txtExtracted texttext/plain29181https://patua.iec.gov.br/bitstreams/37444a74-1a1b-44eb-8166-eaa929cd11b5/download738963b8f3799237bea7bc4fcffab467MD55THUMBNAILCopy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?.pdf.jpgCopy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?.pdf.jpgGenerated Thumbnailimage/jpeg5569https://patua.iec.gov.br/bitstreams/8e54148e-4b4a-47a7-b1b4-57d60d7e8a95/download496a6ba47f690ee414f32ed0ad0ae0caMD56LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses? |
title |
Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses? |
spellingShingle |
Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses? Almeida, Deise Cibele N. de Neoplasias / diagnóstico Neoplasias da Glândula Tireoide / diagnóstico Câncer Papilífero da Tireoide Estresse Oxidativo / genética Idoso / fisiologia Envelhecimento |
title_short |
Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses? |
title_full |
Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses? |
title_fullStr |
Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses? |
title_full_unstemmed |
Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses? |
title_sort |
Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses? |
author |
Almeida, Deise Cibele N. de |
author_facet |
Almeida, Deise Cibele N. de Souza, Michel Platini Caldas de Amorim, Carolina Koury Nassar Maués, Jersey Heitor da Silva Sagica, Fernanda do Espírito Santo Nunes, Caroline Aquino Moreira Oliveria, Edivaldo Herculano Corrêa de |
author_role |
author |
author2 |
Souza, Michel Platini Caldas de Amorim, Carolina Koury Nassar Maués, Jersey Heitor da Silva Sagica, Fernanda do Espírito Santo Nunes, Caroline Aquino Moreira Oliveria, Edivaldo Herculano Corrêa de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Almeida, Deise Cibele N. de Souza, Michel Platini Caldas de Amorim, Carolina Koury Nassar Maués, Jersey Heitor da Silva Sagica, Fernanda do Espírito Santo Nunes, Caroline Aquino Moreira Oliveria, Edivaldo Herculano Corrêa de |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Neoplasias / diagnóstico Neoplasias da Glândula Tireoide / diagnóstico Câncer Papilífero da Tireoide Estresse Oxidativo / genética Idoso / fisiologia Envelhecimento |
topic |
Neoplasias / diagnóstico Neoplasias da Glândula Tireoide / diagnóstico Câncer Papilífero da Tireoide Estresse Oxidativo / genética Idoso / fisiologia Envelhecimento |
description |
Background/Aim: Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, with different clinical features. The aim of the study was to perform a microarray-based analysis in two groups of patients (<45 and ≥45 years old), in order to verify the occurrence of specific copy number alterations (CNAs) that could be associated to different patient behaviors associated with age. Patients and Methods: In order to search and compare genomic alterations that may be related to age, we evaluated the occurrence of CNAs in the genome of 24 PTC samples, divided in two groups (<45 and ≥45 years old). Results: We identified only one region showing a statistically significant difference between the groups (p=0.00357): a deletion of approximately 537 kps in 1p35.3., which was more frequent in patients aged 45 years or older. This is the region where, among others, the gene SESN2 is located, which is activated under oxidative stress and plays an antioxidant role, in addition to protecting the genetic material from damage generated by reactive oxygen species (ROS). Conclusion: This is the first time that a CNA involving the deletion of the SESN2 gene is associated with papillary thyroid carcinomas, particularly in patients aged 45 years and older, indicating that this deletion would lead to a more malignant and prominent tumoral behavior associated to a worst prognosis. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-09-15T16:15:22Z |
dc.date.available.fl_str_mv |
2020-09-15T16:15:22Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ALMEIDA, Deise Cibele N. de et al. Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?. Cancer Genomics and Proteomics, v. 17, n. 5, p. 643-648, Sept./Oct. 2020. DOI: https://doi.org/10.21873/cgp.20220. Disponível em: https://cgp.iiarjournals.org/content/cgp/17/5/643.full.pdf. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4170 |
dc.identifier.issn.-.fl_str_mv |
1790-6245 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.21873/cgp.20220 |
identifier_str_mv |
ALMEIDA, Deise Cibele N. de et al. Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?. Cancer Genomics and Proteomics, v. 17, n. 5, p. 643-648, Sept./Oct. 2020. DOI: https://doi.org/10.21873/cgp.20220. Disponível em: https://cgp.iiarjournals.org/content/cgp/17/5/643.full.pdf. 1790-6245 10.21873/cgp.20220 |
url |
https://patua.iec.gov.br/handle/iec/4170 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
International Institute of Anticancer Research |
publisher.none.fl_str_mv |
International Institute of Anticancer Research |
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reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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