Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg

Detalhes bibliográficos
Autor(a) principal: Azevedo, Maycow Marcos L. de
Data de Publicação: 2017
Outros Autores: Cascaes, Márcia M, Guilhon, Giselle Maria S. P, Andrade, Eloisa Helena de Aguiar, Zoghbi, Maria das Graças B, Silva, Joyce Kelly R. da, Santos, Lourivaldo S, Silva, Silvia Helena M. da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
DOI: 10.1080/14786419.2017.1402311
Texto Completo: https://patua.iec.gov.br/handle/iec/2896
Resumo: Chemical composition of the methanol extract of Myrciaria floribunda leaves was investigated. The nor-lupane triterpenoids platanic acid and messagenic I acid were identified, along with other known triterpenoids (betulinic aldehyde, ursolic acid acetate and betulinic acid), a new lupane triterpenoid (2α,6α,30-trihydroxybetulinic acid) and the flavonoids catechin, quercetrin and mirycitrin. The structures were determined by spectroscopic methods (NMR, LC-MS, GC-MS). The major isolated compound was betulinic acid. The methanol extract and 2α,6α,30-trihydroxybetulinic acid were evaluated for their DPPH scavenging potential. The tested triterpenoid was one hundred times more active than betulinic acid, but less active than the extract. Screening for antimicrobial activity showed that the methanol extract was active against Staphylococcus aureus and Escherichia coli, but inactive against Candida albicans and Candida krusei, while 2α,6α,30-trihydroxybetulinic acid was inactive to all tested microorganisms.
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spelling Azevedo, Maycow Marcos L. deCascaes, Márcia MGuilhon, Giselle Maria S. PAndrade, Eloisa Helena de AguiarZoghbi, Maria das Graças BSilva, Joyce Kelly R. daSantos, Lourivaldo SSilva, Silvia Helena M. da2017-12-01T15:48:54Z2017-12-01T15:48:54Z2017AZEVEDO, Maycow Marcos L. de et al. Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg. Natural Product Research, v. 13, p. 1-10, Nov. 2017. DOI: https://doi.org/10.1080/14786419.2017.14023111478-6419https://patua.iec.gov.br/handle/iec/289610.1080/14786419.2017.1402311Chemical composition of the methanol extract of Myrciaria floribunda leaves was investigated. The nor-lupane triterpenoids platanic acid and messagenic I acid were identified, along with other known triterpenoids (betulinic aldehyde, ursolic acid acetate and betulinic acid), a new lupane triterpenoid (2α,6α,30-trihydroxybetulinic acid) and the flavonoids catechin, quercetrin and mirycitrin. The structures were determined by spectroscopic methods (NMR, LC-MS, GC-MS). The major isolated compound was betulinic acid. The methanol extract and 2α,6α,30-trihydroxybetulinic acid were evaluated for their DPPH scavenging potential. The tested triterpenoid was one hundred times more active than betulinic acid, but less active than the extract. Screening for antimicrobial activity showed that the methanol extract was active against Staphylococcus aureus and Escherichia coli, but inactive against Candida albicans and Candida krusei, while 2α,6α,30-trihydroxybetulinic acid was inactive to all tested microorganisms.Universidade Federal do Pará. Instituto de Ciências Exatas e Naturais. Programa de Pós-Graduação em Química. Belém, PA, Brazil.Museu Paraense Emílio Goeldi. Coordenação de Botânica. Programa de Capacitação Institucional. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Exatas e Naturais. Programa de Pós-Graduação em Química. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Exatas e Naturais. Programa de Pós-Graduação em Química. Belém, PA, Brazil / Museu Paraense Emílio Goeldi. Belém, PA, Brazil.Museu Paraense Emílio Goeldi. Belém, PA, Brazil.Universidade Federal do Pará. Programa de Pós-Graduação em Biotecnologia. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Exatas e Naturais. Programa de Pós-Graduação em Química. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.engTaylor & FrancisLupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMyrciaria floribundaExtratos Vegetais / químicaMyrtaceae / toxicidadePlantas / toxicologiaÁcido betulínicoFlavonoidesinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECLICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/57f9e777-5d61-4898-88e8-3392ec99a4c2/download52f1732ea66fbd1123abe39f5373b797MD52ORIGINALAcesso Embargado.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/1edc402b-c4c2-420e-aedf-1438014be061/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD58TEXTLupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg.pdf.txtLupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg.pdf.txtExtracted texttext/plain2697https://patua.iec.gov.br/bitstreams/a23c0a9c-6643-4b11-8b32-a20e69c6c4a2/download4465f121243c6ab7217764587585f1f2MD56Acesso Embargado.pdf.txtAcesso Embargado.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/5f8274e3-ae18-412a-9f39-c29662d0a8be/downloade1c06d85ae7b8b032bef47e42e4c08f9MD59THUMBNAILLupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg.pdf.jpgLupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg.pdf.jpgGenerated Thumbnailimage/jpeg4781https://patua.iec.gov.br/bitstreams/0c8f703f-70d5-460e-9173-7304b1cfb4a6/download3b4743279d31d52b736072a673cb3dd6MD57Acesso Embargado.pdf.jpgAcesso Embargado.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/19995cfd-3f23-4820-af33-071a77b01524/download71859d578212107f7f8c49a4ce09d9eeMD510iec/28962023-05-23 12:50:51.12oai:patua.iec.gov.br:iec/2896https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-05-23T12:50:51Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4=
dc.title.pt_BR.fl_str_mv Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg
title Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg
spellingShingle Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg
Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg
Azevedo, Maycow Marcos L. de
Myrciaria floribunda
Extratos Vegetais / química
Myrtaceae / toxicidade
Plantas / toxicologia
Ácido betulínico
Flavonoides
Azevedo, Maycow Marcos L. de
Myrciaria floribunda
Extratos Vegetais / química
Myrtaceae / toxicidade
Plantas / toxicologia
Ácido betulínico
Flavonoides
title_short Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg
title_full Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg
title_fullStr Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg
Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg
title_full_unstemmed Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg
Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg
title_sort Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg
author Azevedo, Maycow Marcos L. de
author_facet Azevedo, Maycow Marcos L. de
Azevedo, Maycow Marcos L. de
Cascaes, Márcia M
Guilhon, Giselle Maria S. P
Andrade, Eloisa Helena de Aguiar
Zoghbi, Maria das Graças B
Silva, Joyce Kelly R. da
Santos, Lourivaldo S
Silva, Silvia Helena M. da
Cascaes, Márcia M
Guilhon, Giselle Maria S. P
Andrade, Eloisa Helena de Aguiar
Zoghbi, Maria das Graças B
Silva, Joyce Kelly R. da
Santos, Lourivaldo S
Silva, Silvia Helena M. da
author_role author
author2 Cascaes, Márcia M
Guilhon, Giselle Maria S. P
Andrade, Eloisa Helena de Aguiar
Zoghbi, Maria das Graças B
Silva, Joyce Kelly R. da
Santos, Lourivaldo S
Silva, Silvia Helena M. da
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Azevedo, Maycow Marcos L. de
Cascaes, Márcia M
Guilhon, Giselle Maria S. P
Andrade, Eloisa Helena de Aguiar
Zoghbi, Maria das Graças B
Silva, Joyce Kelly R. da
Santos, Lourivaldo S
Silva, Silvia Helena M. da
dc.subject.decsPrimary.pt_BR.fl_str_mv Myrciaria floribunda
Extratos Vegetais / química
Myrtaceae / toxicidade
Plantas / toxicologia
Ácido betulínico
Flavonoides
topic Myrciaria floribunda
Extratos Vegetais / química
Myrtaceae / toxicidade
Plantas / toxicologia
Ácido betulínico
Flavonoides
description Chemical composition of the methanol extract of Myrciaria floribunda leaves was investigated. The nor-lupane triterpenoids platanic acid and messagenic I acid were identified, along with other known triterpenoids (betulinic aldehyde, ursolic acid acetate and betulinic acid), a new lupane triterpenoid (2α,6α,30-trihydroxybetulinic acid) and the flavonoids catechin, quercetrin and mirycitrin. The structures were determined by spectroscopic methods (NMR, LC-MS, GC-MS). The major isolated compound was betulinic acid. The methanol extract and 2α,6α,30-trihydroxybetulinic acid were evaluated for their DPPH scavenging potential. The tested triterpenoid was one hundred times more active than betulinic acid, but less active than the extract. Screening for antimicrobial activity showed that the methanol extract was active against Staphylococcus aureus and Escherichia coli, but inactive against Candida albicans and Candida krusei, while 2α,6α,30-trihydroxybetulinic acid was inactive to all tested microorganisms.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-12-01T15:48:54Z
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dc.identifier.citation.fl_str_mv AZEVEDO, Maycow Marcos L. de et al. Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg. Natural Product Research, v. 13, p. 1-10, Nov. 2017. DOI: https://doi.org/10.1080/14786419.2017.1402311
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/2896
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dc.identifier.doi.-.fl_str_mv 10.1080/14786419.2017.1402311
identifier_str_mv AZEVEDO, Maycow Marcos L. de et al. Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg. Natural Product Research, v. 13, p. 1-10, Nov. 2017. DOI: https://doi.org/10.1080/14786419.2017.1402311
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