Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3490 |
Resumo: | Pseudomonas aeruginosa is the leading cause of nosocomial infections with high mortality rates owing to the limited therapeutic options for multidrug-resistant Pseudomonas aeruginosa (MDRPA) and metallo-beta-lactamase (MBL)-producing strains. Herein, we present a meta-analysis exploring the association between MDRPA and São Paulo MBL-1 (SPM-1)-producing strains vs. mortality. Online databases were screened to identify studies published between 2006 and 2016. A total of 15 studies, comprising 3,201 cases of P. aeruginosa infection, were included. Our results demonstrated a higher mortality rate among patients infected with MDRPA (44.6%, 363/813) than those with non-MDRPA infection (24.8%, 593/2,388) [odds ratio (OR) 2.39, 95% confidence interval (CI) 1.70-3.36, p <0.00001]. The risk of mortality in patients with non-SPM-1 strains was four times higher than that observed in the patients of the SPM-1 group; however, no statistically significant difference was observed (p = 0.43). In conclusion, the results of our study demonstrated that patients infected with MDRPA had a significantly higher mortality rate than that of patients infected with non-MDRPA strains, especially patients with bloodstream infection (BSI), immunosuppression, and inadequate antimicrobial therapy. The absence of studies on the molecular aspects of blaSPM-1 and its association with mortality limited the analysis; therefore, our results should be interpreted with caution. Our findings also highlight the need for more studies on the molecular aspects of resistance and the peculiarities of different nosocomial settings. |
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Matos, Eliseth Costa Oliveira deAndriolo, Regis BruniRodrigues, Yan CorrêaLima, Patrícia Danielle Lima deCarneiro, Irna Carla do Rosário SouzaLima, Karla Valéria Batista2018-10-03T18:27:26Z2018-10-03T18:27:26Z2018MATOS, Eliseth Costa Oliveira de et al. Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 4, p. 415-420, July-August, 2018.1678-9849https://patua.iec.gov.br/handle/iec/349010.1590/0037-8682-0506-2017Pseudomonas aeruginosa is the leading cause of nosocomial infections with high mortality rates owing to the limited therapeutic options for multidrug-resistant Pseudomonas aeruginosa (MDRPA) and metallo-beta-lactamase (MBL)-producing strains. Herein, we present a meta-analysis exploring the association between MDRPA and São Paulo MBL-1 (SPM-1)-producing strains vs. mortality. Online databases were screened to identify studies published between 2006 and 2016. A total of 15 studies, comprising 3,201 cases of P. aeruginosa infection, were included. Our results demonstrated a higher mortality rate among patients infected with MDRPA (44.6%, 363/813) than those with non-MDRPA infection (24.8%, 593/2,388) [odds ratio (OR) 2.39, 95% confidence interval (CI) 1.70-3.36, p <0.00001]. The risk of mortality in patients with non-SPM-1 strains was four times higher than that observed in the patients of the SPM-1 group; however, no statistically significant difference was observed (p = 0.43). In conclusion, the results of our study demonstrated that patients infected with MDRPA had a significantly higher mortality rate than that of patients infected with non-MDRPA strains, especially patients with bloodstream infection (BSI), immunosuppression, and inadequate antimicrobial therapy. The absence of studies on the molecular aspects of blaSPM-1 and its association with mortality limited the analysis; therefore, our results should be interpreted with caution. Our findings also highlight the need for more studies on the molecular aspects of resistance and the peculiarities of different nosocomial settings.Universidade do Estado do Pará. Departamento de Patologia. Belém, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil.Universidade do Estado do Pará. Departamento de Patologia. Belém, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.engSociedade Brasileira de Medicina TropicalMortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePseudomonas aeruginosa / patogenicidadeInfecções por PseudomonasInfecção Hospitalar / mortalidadeUnidades de Terapia Intensiva / estatística & dados numéricosbeta-LactamasesResistência Microbiana a Medicamentosinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALMortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis.pdfMortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis.pdfapplication/pdf1169115https://patua.iec.gov.br/bitstreams/d0e95a32-486f-4fa7-ac21-400767733015/downloadca7a1ad088b35da3211792a0e4757b81MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/b34db75d-d57f-41fe-9bab-59191210a1c2/download52f1732ea66fbd1123abe39f5373b797MD52TEXTMortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis.pdf.txtMortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis.pdf.txtExtracted texttext/plain25999https://patua.iec.gov.br/bitstreams/b13418c7-1661-49fe-93b1-bd16e50a26b8/downloadabaddc5e1d0d8028225a4729c19ae53dMD55THUMBNAILMortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis.pdf.jpgMortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis.pdf.jpgGenerated Thumbnailimage/jpeg6410https://patua.iec.gov.br/bitstreams/669e64cd-3ffa-45b3-815e-378210507f7f/downloadd44ce590095944c20a5a0f8e2e483ac9MD56iec/34902022-10-20 22:06:53.918oai:patua.iec.gov.br:iec/3490https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:06:53Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis |
title |
Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis |
spellingShingle |
Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis Matos, Eliseth Costa Oliveira de Pseudomonas aeruginosa / patogenicidade Infecções por Pseudomonas Infecção Hospitalar / mortalidade Unidades de Terapia Intensiva / estatística & dados numéricos beta-Lactamases Resistência Microbiana a Medicamentos |
title_short |
Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis |
title_full |
Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis |
title_fullStr |
Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis |
title_full_unstemmed |
Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis |
title_sort |
Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis |
author |
Matos, Eliseth Costa Oliveira de |
author_facet |
Matos, Eliseth Costa Oliveira de Andriolo, Regis Bruni Rodrigues, Yan Corrêa Lima, Patrícia Danielle Lima de Carneiro, Irna Carla do Rosário Souza Lima, Karla Valéria Batista |
author_role |
author |
author2 |
Andriolo, Regis Bruni Rodrigues, Yan Corrêa Lima, Patrícia Danielle Lima de Carneiro, Irna Carla do Rosário Souza Lima, Karla Valéria Batista |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Matos, Eliseth Costa Oliveira de Andriolo, Regis Bruni Rodrigues, Yan Corrêa Lima, Patrícia Danielle Lima de Carneiro, Irna Carla do Rosário Souza Lima, Karla Valéria Batista |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Pseudomonas aeruginosa / patogenicidade Infecções por Pseudomonas Infecção Hospitalar / mortalidade Unidades de Terapia Intensiva / estatística & dados numéricos beta-Lactamases Resistência Microbiana a Medicamentos |
topic |
Pseudomonas aeruginosa / patogenicidade Infecções por Pseudomonas Infecção Hospitalar / mortalidade Unidades de Terapia Intensiva / estatística & dados numéricos beta-Lactamases Resistência Microbiana a Medicamentos |
description |
Pseudomonas aeruginosa is the leading cause of nosocomial infections with high mortality rates owing to the limited therapeutic options for multidrug-resistant Pseudomonas aeruginosa (MDRPA) and metallo-beta-lactamase (MBL)-producing strains. Herein, we present a meta-analysis exploring the association between MDRPA and São Paulo MBL-1 (SPM-1)-producing strains vs. mortality. Online databases were screened to identify studies published between 2006 and 2016. A total of 15 studies, comprising 3,201 cases of P. aeruginosa infection, were included. Our results demonstrated a higher mortality rate among patients infected with MDRPA (44.6%, 363/813) than those with non-MDRPA infection (24.8%, 593/2,388) [odds ratio (OR) 2.39, 95% confidence interval (CI) 1.70-3.36, p <0.00001]. The risk of mortality in patients with non-SPM-1 strains was four times higher than that observed in the patients of the SPM-1 group; however, no statistically significant difference was observed (p = 0.43). In conclusion, the results of our study demonstrated that patients infected with MDRPA had a significantly higher mortality rate than that of patients infected with non-MDRPA strains, especially patients with bloodstream infection (BSI), immunosuppression, and inadequate antimicrobial therapy. The absence of studies on the molecular aspects of blaSPM-1 and its association with mortality limited the analysis; therefore, our results should be interpreted with caution. Our findings also highlight the need for more studies on the molecular aspects of resistance and the peculiarities of different nosocomial settings. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-10-03T18:27:26Z |
dc.date.available.fl_str_mv |
2018-10-03T18:27:26Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MATOS, Eliseth Costa Oliveira de et al. Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 4, p. 415-420, July-August, 2018. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3490 |
dc.identifier.issn.-.fl_str_mv |
1678-9849 |
dc.identifier.doi.-.fl_str_mv |
10.1590/0037-8682-0506-2017 |
identifier_str_mv |
MATOS, Eliseth Costa Oliveira de et al. Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 4, p. 415-420, July-August, 2018. 1678-9849 10.1590/0037-8682-0506-2017 |
url |
https://patua.iec.gov.br/handle/iec/3490 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical |
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IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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