Sapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4386 |
Resumo: | Parkinson's disease (PD) is one of the most important research challenges nowadays. In the past five decades, no significant changes in the elucidation of the whole pathophysiology and therapeutic scenario for PD were found, and possible strategies to stop, reverse or cure the disease seem to be on a far horizon. Historically, the most relevant advances in therapeutics for PD were reached using nonhuman primate (NHP) models. They are considered invaluable models for studies on new therapeutic strategies, due to their unquestionable validity to evaluate the efficiency, reliability, and safety for human use. However, NHP species choice may affect research outcomes and must be evaluated with careful consideration of the trade-offs between convenience, costs, scientific relevance, and clinical predictivity. Sapajus apella is a New World monkey species with prominent characteristics as a model for research on the brain and behavior bearing on the human condition, especially regarding the complex features clinically relevant in PD. Among the New World primates, Sapajus apella monkeys more closely resemble humans in several relevant aspects for investigations in PD than other species that are most used for such purposes. This paper discusses the relevance of Sapajus apella monkeys as model to study and develop new therapeutic approaches for PD based on phylogenetic characteristics, telencephalization coefficient, anatomic structures and pathways, genetic features, immune responses, cognitive abilities, and behavioral repertoires. |
id |
IEC-2_3aac9468cb8c803e604417c63fc138a2 |
---|---|
oai_identifier_str |
oai:patua.iec.gov.br:iec/4386 |
network_acronym_str |
IEC-2 |
network_name_str |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
repository_id_str |
|
spelling |
Muniz, José Augusto Pereira CarneiroLeal, Leon Claudio PinheiroBahia, Carlomagno PachecoKrejcová, Lane Viana2021-08-06T17:46:14Z2021-08-06T17:46:14Z2021MUNIZ, José Augusto Pereira Carneiro et al. Sapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease. Revista Pan-Amazônica de Saúde, v. 12, n. esp., p. 1-11, jun. 2021.2176-6223https://patua.iec.gov.br/handle/iec/438610.5123/S2176-6223202100514Parkinson's disease (PD) is one of the most important research challenges nowadays. In the past five decades, no significant changes in the elucidation of the whole pathophysiology and therapeutic scenario for PD were found, and possible strategies to stop, reverse or cure the disease seem to be on a far horizon. Historically, the most relevant advances in therapeutics for PD were reached using nonhuman primate (NHP) models. They are considered invaluable models for studies on new therapeutic strategies, due to their unquestionable validity to evaluate the efficiency, reliability, and safety for human use. However, NHP species choice may affect research outcomes and must be evaluated with careful consideration of the trade-offs between convenience, costs, scientific relevance, and clinical predictivity. Sapajus apella is a New World monkey species with prominent characteristics as a model for research on the brain and behavior bearing on the human condition, especially regarding the complex features clinically relevant in PD. Among the New World primates, Sapajus apella monkeys more closely resemble humans in several relevant aspects for investigations in PD than other species that are most used for such purposes. This paper discusses the relevance of Sapajus apella monkeys as model to study and develop new therapeutic approaches for PD based on phylogenetic characteristics, telencephalization coefficient, anatomic structures and pathways, genetic features, immune responses, cognitive abilities, and behavioral repertoires.European Union's Horizon 2020 Research and Innovation Program under contract No. 767092.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Centro Nacional de Primatas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Centro Nacional de Primatas. Ananindeua, PA, Brasil / Universidade Federal do Pará. Instituto de Ciências da Saúde. Laboratório de Neuroplasticidade. Belém, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências da Saúde. Laboratório de Neuroplasticidade. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Centro Nacional de Primatas. Ananindeua, PA, Brasil / Universidade Federal do Pará. Instituto de Ciências da Saúde. Laboratório de Neuroplasticidade. Belém, PA, Brasil.engMS/SVS/Instituto Evandro ChagasSapajus apella as a model for the development of novel therapeutic approaches for Parkinson's diseaseSapajus apella como modelo para o desenvolvimento de novas abordagens terapêuticas para a doença de Parkinsoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePrimatas / anatomia & histologiaSapajus apella / anatomia & histologiaDoença de Parkinson / patologiaDoença de Parkinson / veterináriaDoenças Neurodegenerativas / veterináriainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALSapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease.pdfSapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease.pdfapplication/pdf171518https://patua.iec.gov.br/bitstreams/78b5d0fc-f277-4197-8755-70233d0fdff8/download44611613d1b32c91eec0501714baacadMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/d5894a2c-5b53-4fc0-88b9-4d4fc80605bb/download11832eea31b16df8613079d742d61793MD52TEXTSapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease.pdf.txtSapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease.pdf.txtExtracted texttext/plain56170https://patua.iec.gov.br/bitstreams/2523e837-cce5-4701-bb0c-5d2f310538f1/download8e62709de6ebce5141cf08d695ce3d62MD55THUMBNAILSapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease.pdf.jpgSapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease.pdf.jpgGenerated Thumbnailimage/jpeg5578https://patua.iec.gov.br/bitstreams/40166428-2f3a-4397-b510-fcfc1d8dcd2f/downloada183309b45a2246bb8a15993c2e5df85MD56iec/43862022-10-20 22:22:55.078oai:patua.iec.gov.br:iec/4386https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:22:55Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falsePGI+TGljZW7Dp2EgZGUgRGlzdHJpYnVpw6fDo28gTsOjbyBFeGNsdXNpdmE8L2I+DQoNClRvZG8gZGVwb3NpdGFudGUgZGUgbWF0ZXJpYWwgbm8gUGF0dcOhIGRldmUgY29uY2VkZXIgYW8gSW5zdGl0dXRvIEV2YW5kcm8gQ2hhZ2FzIHVtYSBMaWNlbsOnYSBkZSBEaXN0cmlidWnDp8OjbyBOw6NvIEV4Y2x1c2l2YSBwYXJhIHRvcm5hciBlIG1hbnRlciBhY2Vzc8OtdmVpcyBvcyBzZXVzIGRvY3VtZW50b3MgZW0gZm9ybWF0byBkaWdpdGFsLiANCg0KQ29tIGEgY29uY2Vzc8OjbyBkZXNzYSBsaWNlbsOnYSBuw6NvIGV4Y2x1c2l2YSwgbyBkZXBvc2l0YW50ZSBjb250aW51YSBhIHJldGVyIHRvZG9zIG9zIGRpcmVpdG9zIGRlIGF1dG9yLg0KDQpBbyBhc3NpbmFyIGUgZW50cmVnYXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKQ0KDQphKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRlIHNldSBkb2N1bWVudG8uDQoNCmIpIENvbmNlZGUgYW8gSW5zdGl0dXRvIEV2YW5kcm8gQ2hhZ2FzIG8gZGlyZWl0byBuw6NvIGV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyIGUvb3UgZGlzdHJpYnVpciBubyA8Yj5QYXR1w6E8L2I+LCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgcG9yIHF1YWxxdWVyIG91dHJvIG1laW8uDQoNCmMpIERlY2xhcmEgcXVlIGF1dG9yaXphIG8gSW5zdGl0dXRvIEV2YW5kcm8gQ2hhZ2FzIGEgYXJxdWl2YXIgbWFpcyBkZSB1bWEgY8OzcGlhIGRlc3NlIGRvY3VtZW50byBlIGNvbnZlcnTDqi1sbywgc2VtIGFsdGVyYXIgbyBzZXUgY29udGXDumRvLCBwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgZmljaGVpcm8sIG1laW8gb3Ugc3Vwb3J0ZSwgcGFyYSBlZmVpdG9zIGRlIHNlZ3VyYW7Dp2EsIHByZXNlcnZhw6fDo28gKGJhY2t1cCkgZSBhY2Vzc28uDQoNCmQpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCBlIHF1ZSBkZXTDqW0gbyBkaXJlaXRvIGRlIGNvbmNlZGVyIGEgdGVyY2Vpcm9zIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuDQoNCmUpIERlY2xhcmEgcXVlLCBubyBjYXNvIGRvIGRvY3VtZW50byBzdWJtZXRpZG8gY29udGVyIG1hdGVyaWFsIGRvIHF1YWwgbsOjbyBkZXTDqW0gb3MgZGlyZWl0b3MgZGUgYXV0b3IsIG9idGV2ZSBhIGF1dG9yaXphw6fDo28gaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhbyBJbnN0aXR1dG8gRXZhbmRybyBDaGFnYXMgb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIHV0aWxpesOhLWxvcyBsZWdhbG1lbnRlLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBjb250ZcO6ZG8gZG8gZG9jdW1lbnRvIGVudHJlZ3VlLg0KDQpmKSBTRSBPIERPQ1VNRU5UTyBFTlRSRUdVRSBGT1IgQkFTRUFETyBFTSBUUkFCQUxITyBGSU5BTkNJQURPIE9VIEFQT0lBRE8gUE9SIE9VVFJBIElOU1RJVFVJw4fDg08gUVVFIE7Dg08gTyBJTlNUSVRVVE8gRVZBTkRSTyBDSEFHQVMsIERFQ0xBUkEgUVVFIENVTVBSSVUgUVVBSVNRVUVSIE9CUklHQcOHw5VFUyBFWElHSURBUyBQRUxPIFJFU1BFQ1RJVk8gQ09OVFJBVE8gT1UgQUNPUkRPLg0KDQpPIEluc3RpdHV0byBFdmFuZHJvIENoYWdhcyBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgbyhzKSBub21lKHMpIGRvKHMpIGF1dG9yKGVzKSBkb3MgZGlyZWl0b3MgZG8gZG9jdW1lbnRvIGVudHJlZ3VlIGUgbsOjbyBmYXLDoSBxdWFscXVlciBhbHRlcmHDp8OjbyBhbMOpbSBkbyBwcmV2aXN0byBuYSBhbMOtbmVhIGIpLg== |
dc.title.pt_BR.fl_str_mv |
Sapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease |
dc.title.alternative.pt_BR.fl_str_mv |
Sapajus apella como modelo para o desenvolvimento de novas abordagens terapêuticas para a doença de Parkinson |
title |
Sapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease |
spellingShingle |
Sapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease Muniz, José Augusto Pereira Carneiro Primatas / anatomia & histologia Sapajus apella / anatomia & histologia Doença de Parkinson / patologia Doença de Parkinson / veterinária Doenças Neurodegenerativas / veterinária |
title_short |
Sapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease |
title_full |
Sapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease |
title_fullStr |
Sapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease |
title_full_unstemmed |
Sapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease |
title_sort |
Sapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease |
author |
Muniz, José Augusto Pereira Carneiro |
author_facet |
Muniz, José Augusto Pereira Carneiro Leal, Leon Claudio Pinheiro Bahia, Carlomagno Pacheco Krejcová, Lane Viana |
author_role |
author |
author2 |
Leal, Leon Claudio Pinheiro Bahia, Carlomagno Pacheco Krejcová, Lane Viana |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Muniz, José Augusto Pereira Carneiro Leal, Leon Claudio Pinheiro Bahia, Carlomagno Pacheco Krejcová, Lane Viana |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Primatas / anatomia & histologia Sapajus apella / anatomia & histologia Doença de Parkinson / patologia Doença de Parkinson / veterinária Doenças Neurodegenerativas / veterinária |
topic |
Primatas / anatomia & histologia Sapajus apella / anatomia & histologia Doença de Parkinson / patologia Doença de Parkinson / veterinária Doenças Neurodegenerativas / veterinária |
description |
Parkinson's disease (PD) is one of the most important research challenges nowadays. In the past five decades, no significant changes in the elucidation of the whole pathophysiology and therapeutic scenario for PD were found, and possible strategies to stop, reverse or cure the disease seem to be on a far horizon. Historically, the most relevant advances in therapeutics for PD were reached using nonhuman primate (NHP) models. They are considered invaluable models for studies on new therapeutic strategies, due to their unquestionable validity to evaluate the efficiency, reliability, and safety for human use. However, NHP species choice may affect research outcomes and must be evaluated with careful consideration of the trade-offs between convenience, costs, scientific relevance, and clinical predictivity. Sapajus apella is a New World monkey species with prominent characteristics as a model for research on the brain and behavior bearing on the human condition, especially regarding the complex features clinically relevant in PD. Among the New World primates, Sapajus apella monkeys more closely resemble humans in several relevant aspects for investigations in PD than other species that are most used for such purposes. This paper discusses the relevance of Sapajus apella monkeys as model to study and develop new therapeutic approaches for PD based on phylogenetic characteristics, telencephalization coefficient, anatomic structures and pathways, genetic features, immune responses, cognitive abilities, and behavioral repertoires. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-08-06T17:46:14Z |
dc.date.available.fl_str_mv |
2021-08-06T17:46:14Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MUNIZ, José Augusto Pereira Carneiro et al. Sapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease. Revista Pan-Amazônica de Saúde, v. 12, n. esp., p. 1-11, jun. 2021. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4386 |
dc.identifier.issn.-.fl_str_mv |
2176-6223 |
dc.identifier.doi.-.fl_str_mv |
10.5123/S2176-6223202100514 |
identifier_str_mv |
MUNIZ, José Augusto Pereira Carneiro et al. Sapajus apella as a model for the development of novel therapeutic approaches for Parkinson's disease. Revista Pan-Amazônica de Saúde, v. 12, n. esp., p. 1-11, jun. 2021. 2176-6223 10.5123/S2176-6223202100514 |
url |
https://patua.iec.gov.br/handle/iec/4386 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MS/SVS/Instituto Evandro Chagas |
publisher.none.fl_str_mv |
MS/SVS/Instituto Evandro Chagas |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
instname_str |
Instituto Evandro Chagas (IEC) |
instacron_str |
IEC |
institution |
IEC |
reponame_str |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
collection |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
bitstream.url.fl_str_mv |
https://patua.iec.gov.br/bitstreams/78b5d0fc-f277-4197-8755-70233d0fdff8/download https://patua.iec.gov.br/bitstreams/d5894a2c-5b53-4fc0-88b9-4d4fc80605bb/download https://patua.iec.gov.br/bitstreams/2523e837-cce5-4701-bb0c-5d2f310538f1/download https://patua.iec.gov.br/bitstreams/40166428-2f3a-4397-b510-fcfc1d8dcd2f/download |
bitstream.checksum.fl_str_mv |
44611613d1b32c91eec0501714baacad 11832eea31b16df8613079d742d61793 8e62709de6ebce5141cf08d695ce3d62 a183309b45a2246bb8a15993c2e5df85 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC) |
repository.mail.fl_str_mv |
clariceneta@iec.gov.br || Biblioteca@iec.gov.br |
_version_ |
1787533068330860544 |