Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/2471 |
Resumo: | Animal control measures in Latin America have decreased the incidence of urban human rabies transmitted by dogs and cats; currently most cases of human rabies are transmitted by bats. In 2004-2005, rabies outbreaks in populations living in rural Brazil prompted widespread vaccination of exposed and at-risk populations. More than 3,500 inhabitants of Augusto Correa (Pará State) received either post-exposure (PEP) or pre-exposure (PrEP) prophylaxis. This study evaluated the persistence of rabies virus-neutralizing antibodies (RVNA) annually for 4 years post-vaccination. The aim was to evaluate the impact of rabies PrEP and PEP in a population at risk living in a rural setting to help improve management of vampire bat exposure and provide additional data on the need for booster vaccination against rabies. Methodology/Principal Findings This prospective study was conducted in 2007 through 2009 in a population previously vaccinated in 2005; study participants were followed-up annually. An RVNA titer >0.5 International Units (IU)/mL was chosen as the threshold of seroconversion. Participants with titers <0.5 IU/mL or Equivalent Units (EU)/mL at enrollment or at subsequent annual visits received booster doses of purified Vero cell rabies vaccine (PVRV). Adherence of the participants from this Amazonian community to the study protocol was excellent, with 428 of the 509 (84 percent) who attended the first interview in 2007 returning for the final visit in 2009. The long-term RVNA persistence was good, with 85-88.0 percent of the non-boosted participants evaluated at each yearly follow-up visit remaining seroconverted. Similar RVNA persistence profiles were observed in participants originally given PEP or PrEP in 2005, and the GMT of the study population remained >1 IU/mL 4 years after vaccination. At the end of the study, 51 subjects (11.9 percent of the interviewed population) had received at least one dose of booster since their vaccination in 2005. Conclusions/Significance This study and the events preceding it underscore the need for the health authorities in rabies enzootic countries to decide on the best strategies and timing for the introduction of routine rabies PrEP vaccination in affected areas. |
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Sousa, Rita Catarina MedeirosJusot, VivianeHouillon, GuyRasuli, AnvarMartorelli, LuziaKataoka, Ana PaulaMechlia, Mohamed BenLe Guern, Anne-SophieRodrigues, LiliamAssef, RhomeroMaestri, AlvinoLima, ReynaldoRotivel, YolandeBosch-Castells, ValerieTordo, Noël2017-02-03T12:31:20Z2017-02-03T12:31:20Z2016SOUSA, Rita Catarina Medeiros et al. Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil. PLoS Neglected Tropical Diseases, v. 10, n. 9, 2016.1935-2735https://patua.iec.gov.br/handle/iec/247110.1371/journal.pntd.0004920Animal control measures in Latin America have decreased the incidence of urban human rabies transmitted by dogs and cats; currently most cases of human rabies are transmitted by bats. In 2004-2005, rabies outbreaks in populations living in rural Brazil prompted widespread vaccination of exposed and at-risk populations. More than 3,500 inhabitants of Augusto Correa (Pará State) received either post-exposure (PEP) or pre-exposure (PrEP) prophylaxis. This study evaluated the persistence of rabies virus-neutralizing antibodies (RVNA) annually for 4 years post-vaccination. The aim was to evaluate the impact of rabies PrEP and PEP in a population at risk living in a rural setting to help improve management of vampire bat exposure and provide additional data on the need for booster vaccination against rabies. Methodology/Principal Findings This prospective study was conducted in 2007 through 2009 in a population previously vaccinated in 2005; study participants were followed-up annually. An RVNA titer >0.5 International Units (IU)/mL was chosen as the threshold of seroconversion. Participants with titers <0.5 IU/mL or Equivalent Units (EU)/mL at enrollment or at subsequent annual visits received booster doses of purified Vero cell rabies vaccine (PVRV). Adherence of the participants from this Amazonian community to the study protocol was excellent, with 428 of the 509 (84 percent) who attended the first interview in 2007 returning for the final visit in 2009. The long-term RVNA persistence was good, with 85-88.0 percent of the non-boosted participants evaluated at each yearly follow-up visit remaining seroconverted. Similar RVNA persistence profiles were observed in participants originally given PEP or PrEP in 2005, and the GMT of the study population remained >1 IU/mL 4 years after vaccination. At the end of the study, 51 subjects (11.9 percent of the interviewed population) had received at least one dose of booster since their vaccination in 2005. Conclusions/Significance This study and the events preceding it underscore the need for the health authorities in rabies enzootic countries to decide on the best strategies and timing for the introduction of routine rabies PrEP vaccination in affected areas.Universidade Federal do Para. Belém, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Sanofi Pasteur. Lyon, France.Sanofi Pasteur. Lyon, France.Sanofi Pasteur. Lyon, France.Centro de Controle de Zoonoses. São Paulo, SP, Brasil.Centro de Controle de Zoonoses. São Paulo, SP, Brasil.Institut Pasteur. Paris, France.Institut Pasteur. Paris, France.Universidade Federal do Para. Belém, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Universidade Federal do Para. Belém, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Universidade Federal do Para. Belém, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Secretaria de Saúde do Estado do Para. Belém, PA, Brasil.Institut Pasteur. Paris, FranceSanofi Pasteur. Lyon, France.Institut Pasteur. Paris, France / Secretaria de Saúde do Estado do Para. Belém, PA, Brasil / Institut Pasteur de Guine. Conakry, Guinea / Gamal Abdel Nasser University. Conakry, Guinea.application/pdfengPublic Library of SciencePersistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in BrazilPersistência dos anticorpos neutralizantes do vírus da raiva após a vacinação de população após o surto de raiva de morcego vampiro no Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20072009Raiva / epidemiologiaVírus da Raiva / imunologiaVacinas Antirrábicas / imunologiaAnticorpos Neutralizantes / imunologiaImunização SecundáriaPopulação RuralEstudos ProspectivosEcossistema AmazônicoFatores de TempoBrasil (BR)info:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALPersistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil.pdfapplication/pdf1845280https://patua.iec.gov.br/bitstreams/29e183cb-33fc-408b-855d-bcdefb862ffb/downloadfb73852535fc01183e171ce3cb9275a6MD51TEXTPersistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil.pdf.txtPersistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil.pdf.txtExtracted texttext/plain56173https://patua.iec.gov.br/bitstreams/2d548999-da20-4fd4-9f6f-adbf86a4787d/downloadaa8b843bd9d81694bb30c8d7a85a74e0MD55THUMBNAILPersistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil.pdf.jpgPersistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil.pdf.jpgGenerated Thumbnailimage/jpeg5987https://patua.iec.gov.br/bitstreams/3bb59380-88e9-44d2-9aa3-f7326c58883e/download3c785bcd36b7e705ec1d8326b105872fMD56LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil |
dc.title.alternative.pt_BR.fl_str_mv |
Persistência dos anticorpos neutralizantes do vírus da raiva após a vacinação de população após o surto de raiva de morcego vampiro no Brasil |
title |
Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil |
spellingShingle |
Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil Sousa, Rita Catarina Medeiros Raiva / epidemiologia Vírus da Raiva / imunologia Vacinas Antirrábicas / imunologia Anticorpos Neutralizantes / imunologia Imunização Secundária População Rural Estudos Prospectivos Ecossistema Amazônico Fatores de Tempo Brasil (BR) |
title_short |
Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil |
title_full |
Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil |
title_fullStr |
Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil |
title_full_unstemmed |
Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil |
title_sort |
Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil |
author |
Sousa, Rita Catarina Medeiros |
author_facet |
Sousa, Rita Catarina Medeiros Jusot, Viviane Houillon, Guy Rasuli, Anvar Martorelli, Luzia Kataoka, Ana Paula Mechlia, Mohamed Ben Le Guern, Anne-Sophie Rodrigues, Liliam Assef, Rhomero Maestri, Alvino Lima, Reynaldo Rotivel, Yolande Bosch-Castells, Valerie Tordo, Noël |
author_role |
author |
author2 |
Jusot, Viviane Houillon, Guy Rasuli, Anvar Martorelli, Luzia Kataoka, Ana Paula Mechlia, Mohamed Ben Le Guern, Anne-Sophie Rodrigues, Liliam Assef, Rhomero Maestri, Alvino Lima, Reynaldo Rotivel, Yolande Bosch-Castells, Valerie Tordo, Noël |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Sousa, Rita Catarina Medeiros Jusot, Viviane Houillon, Guy Rasuli, Anvar Martorelli, Luzia Kataoka, Ana Paula Mechlia, Mohamed Ben Le Guern, Anne-Sophie Rodrigues, Liliam Assef, Rhomero Maestri, Alvino Lima, Reynaldo Rotivel, Yolande Bosch-Castells, Valerie Tordo, Noël |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Raiva / epidemiologia Vírus da Raiva / imunologia Vacinas Antirrábicas / imunologia Anticorpos Neutralizantes / imunologia Imunização Secundária População Rural Estudos Prospectivos Ecossistema Amazônico Fatores de Tempo Brasil (BR) |
topic |
Raiva / epidemiologia Vírus da Raiva / imunologia Vacinas Antirrábicas / imunologia Anticorpos Neutralizantes / imunologia Imunização Secundária População Rural Estudos Prospectivos Ecossistema Amazônico Fatores de Tempo Brasil (BR) |
description |
Animal control measures in Latin America have decreased the incidence of urban human rabies transmitted by dogs and cats; currently most cases of human rabies are transmitted by bats. In 2004-2005, rabies outbreaks in populations living in rural Brazil prompted widespread vaccination of exposed and at-risk populations. More than 3,500 inhabitants of Augusto Correa (Pará State) received either post-exposure (PEP) or pre-exposure (PrEP) prophylaxis. This study evaluated the persistence of rabies virus-neutralizing antibodies (RVNA) annually for 4 years post-vaccination. The aim was to evaluate the impact of rabies PrEP and PEP in a population at risk living in a rural setting to help improve management of vampire bat exposure and provide additional data on the need for booster vaccination against rabies. Methodology/Principal Findings This prospective study was conducted in 2007 through 2009 in a population previously vaccinated in 2005; study participants were followed-up annually. An RVNA titer >0.5 International Units (IU)/mL was chosen as the threshold of seroconversion. Participants with titers <0.5 IU/mL or Equivalent Units (EU)/mL at enrollment or at subsequent annual visits received booster doses of purified Vero cell rabies vaccine (PVRV). Adherence of the participants from this Amazonian community to the study protocol was excellent, with 428 of the 509 (84 percent) who attended the first interview in 2007 returning for the final visit in 2009. The long-term RVNA persistence was good, with 85-88.0 percent of the non-boosted participants evaluated at each yearly follow-up visit remaining seroconverted. Similar RVNA persistence profiles were observed in participants originally given PEP or PrEP in 2005, and the GMT of the study population remained >1 IU/mL 4 years after vaccination. At the end of the study, 51 subjects (11.9 percent of the interviewed population) had received at least one dose of booster since their vaccination in 2005. Conclusions/Significance This study and the events preceding it underscore the need for the health authorities in rabies enzootic countries to decide on the best strategies and timing for the introduction of routine rabies PrEP vaccination in affected areas. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
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2017-02-03T12:31:20Z |
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2017-02-03T12:31:20Z |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUSA, Rita Catarina Medeiros et al. Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil. PLoS Neglected Tropical Diseases, v. 10, n. 9, 2016. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/2471 |
dc.identifier.issn.-.fl_str_mv |
1935-2735 |
dc.identifier.doi.-.fl_str_mv |
10.1371/journal.pntd.0004920 |
identifier_str_mv |
SOUSA, Rita Catarina Medeiros et al. Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil. PLoS Neglected Tropical Diseases, v. 10, n. 9, 2016. 1935-2735 10.1371/journal.pntd.0004920 |
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https://patua.iec.gov.br/handle/iec/2471 |
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Public Library of Science |
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