Lymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiers
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4652 |
Resumo: | Introduction: Canova is a complex homeopathic medicine that enhances a specific immunologic responses against several exogenous and endogenous conditions. Canova activates macrophages both in vivo and in vitro. Aim and method: We evaluated the effects of macrophages activated by Canova in vivo and ex vitro in the proliferation of lymphocytes. Canova was used to activate Cebus apella macrophages in vivo or ex vitro with Canova. Lymphocytes were cultured with the macrophage culture medium. The analysis of Canova effects in cultured lymphocytes was performed according to the cell cycle phase using flow cytometry. The Interferon gamma and Interleukin-5 cytokines quantification in these lymphocyte culture media was performed by Enzyme-linked immunosorbent assay (ELISA). Results: We observed that Canova actives macrophages in vivo and ex vitro. The lymphocytes cultured in a supplemented medium with macrophages activated by Canova treatment presented a higher number of proliferation cells than lymphocytes not exposed to macrophages activated by Canova. The Interferon gamma and Interleukin-5 cytokines were only observed in the medium of lymphocytes exposed to macrophages activated by Canova. Thus, Canova has potential as a new adjuvant therapy. |
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Moreira, Carlos Onete CoelhoCosta, Joana de Fátima Ferreira Borges daLeal, Mariana FerreiraAndrade, Edilson FerreiraRezende, Alexandre PingarilhoImbeloni, Aline AmaralMuniz, José Augusto Pereira CarneiroSmith, Marília de Arruda CardosoBurbano, Rommel Mário RodríguesAssumpção, Paulo Pimentel de2022-09-09T12:17:43Z2022-09-09T12:17:43Z2012MOREIRA, Carlos Onete Coelho et al. Lymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiers. Homeopathy, v. 101, n. 1, p. 74-79, Jan. 2012. DOI: https://doi.org/10.1016/j.homp.2011.09.001.1475-4916https://patua.iec.gov.br/handle/iec/465210.1016/j.homp.2011.09.001.Introduction: Canova is a complex homeopathic medicine that enhances a specific immunologic responses against several exogenous and endogenous conditions. Canova activates macrophages both in vivo and in vitro. Aim and method: We evaluated the effects of macrophages activated by Canova in vivo and ex vitro in the proliferation of lymphocytes. Canova was used to activate Cebus apella macrophages in vivo or ex vitro with Canova. Lymphocytes were cultured with the macrophage culture medium. The analysis of Canova effects in cultured lymphocytes was performed according to the cell cycle phase using flow cytometry. The Interferon gamma and Interleukin-5 cytokines quantification in these lymphocyte culture media was performed by Enzyme-linked immunosorbent assay (ELISA). Results: We observed that Canova actives macrophages in vivo and ex vitro. The lymphocytes cultured in a supplemented medium with macrophages activated by Canova treatment presented a higher number of proliferation cells than lymphocytes not exposed to macrophages activated by Canova. The Interferon gamma and Interleukin-5 cytokines were only observed in the medium of lymphocytes exposed to macrophages activated by Canova. Thus, Canova has potential as a new adjuvant therapy.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal do Pará. Instituto de Ciências Biológicas. Laboratório de Citogenética Humana. Belém, PA, Brazil / Universidade Federal do Pará. Hospital Universitário João de Barros Barreto. Serviço de Cirurgia. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Laboratório de Citogenética Humana. Belém, PA, Brazil.Universidade Federal de São Paulo. Departamento de Morfologia e Genética. São Paulo, SP, Brazil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Laboratório de Citogenética Humana. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Laboratório de Citogenética Humana. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Centro Nacional de Primatas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Centro Nacional de Primatas. Ananindeua, PA, Brasil.Universidade Federal de São Paulo. Departamento de Morfologia e Genética. São Paulo, SP, Brazil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Laboratório de Citogenética Humana. Belém, PA, Brazil.Universidade Federal do Pará. Hospital Universitário João de Barros Barreto. Serviço de Cirurgia. Belém, PA, Brazil.enengThieme GruppeLymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePrimatas / anatomia & histologiaSapajus apella / anatomia & histologiaMedicamento Homeopático / uso terapêuticoMacrofagosSistema ImunitárioCiclo CelularCitocinas / genéticainfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAcesso Embargado.pdfAcesso Embargado.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/0c4d038d-510d-4518-9f39-401df0e09e37/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/34274944-4dc5-49b7-b8bb-757394466b04/download11832eea31b16df8613079d742d61793MD52TEXTAcesso Embargado.pdf.txtAcesso Embargado.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/3a275486-4d34-477f-87a7-24a87b23e068/downloade1c06d85ae7b8b032bef47e42e4c08f9MD55THUMBNAILAcesso Embargado.pdf.jpgAcesso Embargado.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/a621fd7c-2cd6-4caa-b613-97b3aba49d79/download71859d578212107f7f8c49a4ce09d9eeMD56iec/46522022-10-20 23:36:26.713oai:patua.iec.gov.br:iec/4652https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T23:36:26Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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 |
dc.title.pt_BR.fl_str_mv |
Lymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiers |
title |
Lymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiers |
spellingShingle |
Lymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiers Moreira, Carlos Onete Coelho Primatas / anatomia & histologia Sapajus apella / anatomia & histologia Medicamento Homeopático / uso terapêutico Macrofagos Sistema Imunitário Ciclo Celular Citocinas / genética |
title_short |
Lymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiers |
title_full |
Lymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiers |
title_fullStr |
Lymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiers |
title_full_unstemmed |
Lymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiers |
title_sort |
Lymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiers |
author |
Moreira, Carlos Onete Coelho |
author_facet |
Moreira, Carlos Onete Coelho Costa, Joana de Fátima Ferreira Borges da Leal, Mariana Ferreira Andrade, Edilson Ferreira Rezende, Alexandre Pingarilho Imbeloni, Aline Amaral Muniz, José Augusto Pereira Carneiro Smith, Marília de Arruda Cardoso Burbano, Rommel Mário Rodrígues Assumpção, Paulo Pimentel de |
author_role |
author |
author2 |
Costa, Joana de Fátima Ferreira Borges da Leal, Mariana Ferreira Andrade, Edilson Ferreira Rezende, Alexandre Pingarilho Imbeloni, Aline Amaral Muniz, José Augusto Pereira Carneiro Smith, Marília de Arruda Cardoso Burbano, Rommel Mário Rodrígues Assumpção, Paulo Pimentel de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Moreira, Carlos Onete Coelho Costa, Joana de Fátima Ferreira Borges da Leal, Mariana Ferreira Andrade, Edilson Ferreira Rezende, Alexandre Pingarilho Imbeloni, Aline Amaral Muniz, José Augusto Pereira Carneiro Smith, Marília de Arruda Cardoso Burbano, Rommel Mário Rodrígues Assumpção, Paulo Pimentel de |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Primatas / anatomia & histologia Sapajus apella / anatomia & histologia Medicamento Homeopático / uso terapêutico Macrofagos Sistema Imunitário Ciclo Celular Citocinas / genética |
topic |
Primatas / anatomia & histologia Sapajus apella / anatomia & histologia Medicamento Homeopático / uso terapêutico Macrofagos Sistema Imunitário Ciclo Celular Citocinas / genética |
description |
Introduction: Canova is a complex homeopathic medicine that enhances a specific immunologic responses against several exogenous and endogenous conditions. Canova activates macrophages both in vivo and in vitro. Aim and method: We evaluated the effects of macrophages activated by Canova in vivo and ex vitro in the proliferation of lymphocytes. Canova was used to activate Cebus apella macrophages in vivo or ex vitro with Canova. Lymphocytes were cultured with the macrophage culture medium. The analysis of Canova effects in cultured lymphocytes was performed according to the cell cycle phase using flow cytometry. The Interferon gamma and Interleukin-5 cytokines quantification in these lymphocyte culture media was performed by Enzyme-linked immunosorbent assay (ELISA). Results: We observed that Canova actives macrophages in vivo and ex vitro. The lymphocytes cultured in a supplemented medium with macrophages activated by Canova treatment presented a higher number of proliferation cells than lymphocytes not exposed to macrophages activated by Canova. The Interferon gamma and Interleukin-5 cytokines were only observed in the medium of lymphocytes exposed to macrophages activated by Canova. Thus, Canova has potential as a new adjuvant therapy. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2022-09-09T12:17:43Z |
dc.date.available.fl_str_mv |
2022-09-09T12:17:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MOREIRA, Carlos Onete Coelho et al. Lymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiers. Homeopathy, v. 101, n. 1, p. 74-79, Jan. 2012. DOI: https://doi.org/10.1016/j.homp.2011.09.001. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4652 |
dc.identifier.issn.-.fl_str_mv |
1475-4916 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1016/j.homp.2011.09.001. |
identifier_str_mv |
MOREIRA, Carlos Onete Coelho et al. Lymphocyte proliferation stimulated by activated Cebus Apella marcophages treated whit a complex homeopathic immune response modifiers. Homeopathy, v. 101, n. 1, p. 74-79, Jan. 2012. DOI: https://doi.org/10.1016/j.homp.2011.09.001. 1475-4916 10.1016/j.homp.2011.09.001. |
url |
https://patua.iec.gov.br/handle/iec/4652 |
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en eng |
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dc.publisher.none.fl_str_mv |
Thieme Gruppe |
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Thieme Gruppe |
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