Genetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4431 |
Resumo: | Abstract: Genetic polymorphisms involved in mercury toxicokinetics and toxicodynamics may be associated with severe mercury toxicity. This study aimed to investigate the impact of an ALAD polymorphism on chronic mercury exposure and the health situation of indigenous children from the Brazilian Amazon. One-hundred-and-three indigenous children (under 15 years old) were included and genotyped (rs1800435) using a TaqMan validated assay. The mean age was 6.6 ± 4.5 years old, 60% were female, 49% presented with anemia, and the mean hair mercury concentration was 7.0 ± 4.5 (1.4–23.9) µg/g, with 49% exceeding the reference limit (≥6.0 µg/g). Only two children were heterozygous ALAD, while the others were all wild type. Minor allele frequency (ALAD G) and heterozygous genotype (ALAD CG) were 1% and 2%, respectively. The two children (12 and 14 years old) with the ALAD polymorphism had mercury levels above the average as well as had neurological symptoms related to chronic mercury exposure, such as visual field alterations, memory deficit, distal neuropathy, and toe amyotrophy. Both children also reported frequent consumption of fish in the diet, at least three times a week. In conclusion, our data confirm that an ALAD polymorphism can contribute to mercury half-life time, harmful effects, and neuropsychological disorders in indigenous children with chronic mercury exposure to gold mining activity |
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Perini, Jamila AlessandraSilva, Mayara CalixtoVasconcellos, Ana Claudia Santiago deViana, Paulo Victor SousaLima, Marcelo de OliveiraJesus, Iracina Maura deKempton, Joeseph WilliamOliveira, Rogério Adas AyresHacon, Sandra SouzaBasta, Paulo Cesar2021-08-30T13:35:31Z2021-08-30T13:35:31Z2021PERINI, Jamila Alessandra et al. Genetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon. International Journal of Environmental Research and Public Health, v. 18, n. 16, p. 1-12, Aug. 2021.1660-4601https://patua.iec.gov.br/handle/iec/443110.3390/ijerph18168746Abstract: Genetic polymorphisms involved in mercury toxicokinetics and toxicodynamics may be associated with severe mercury toxicity. This study aimed to investigate the impact of an ALAD polymorphism on chronic mercury exposure and the health situation of indigenous children from the Brazilian Amazon. One-hundred-and-three indigenous children (under 15 years old) were included and genotyped (rs1800435) using a TaqMan validated assay. The mean age was 6.6 ± 4.5 years old, 60% were female, 49% presented with anemia, and the mean hair mercury concentration was 7.0 ± 4.5 (1.4–23.9) µg/g, with 49% exceeding the reference limit (≥6.0 µg/g). Only two children were heterozygous ALAD, while the others were all wild type. Minor allele frequency (ALAD G) and heterozygous genotype (ALAD CG) were 1% and 2%, respectively. The two children (12 and 14 years old) with the ALAD polymorphism had mercury levels above the average as well as had neurological symptoms related to chronic mercury exposure, such as visual field alterations, memory deficit, distal neuropathy, and toe amyotrophy. Both children also reported frequent consumption of fish in the diet, at least three times a week. In conclusion, our data confirm that an ALAD polymorphism can contribute to mercury half-life time, harmful effects, and neuropsychological disorders in indigenous children with chronic mercury exposure to gold mining activityThis research was funded by the Vice-Presidency of Environment, Care and Health Promotion (VPPAS) of Fundação Oswaldo Cruz through Decentralized Execution of Resources Document No. 175/2018, Process: 25000.209221/2018-18, signed between the Fundação Oswaldo Cruz and the Special Department for Indigenous Health, both under the Ministry of Health. The non-governmental organization WWF-Brasil offered financial support to disseminate the results of the research. This study was supported by the Brazilian agency Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro - FAPERJ, Brazil.Centro Universitário Estadual da Zona Oeste. Laboratório de Pesquisa de Ciências Farmacêuticas. Rio de Janeiro, RJ, Brazil.Centro Universitário Estadual da Zona Oeste. Laboratório de Pesquisa de Ciências Farmacêuticas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Escola Politécnica de Saúde Joaquim Venâncio. Laboratório de Educação Profissional em Vigilância em Saúde. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Centro de Referência Professor Hélio Fraga. Rio de Janeiro, RJ, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Faculty of Medicine. Imperial College London. Medical School Building. St Mary’s Hospital. Norfolk Place. London , UK.Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brazil.engMDPIGenetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMercúrio / toxicidadeSintase do Porfobilinogênio / análiseIntoxicação do Sistema Nervoso por MercúrioPolimorfismo GenéticoSaúde AmbientalIngestão de AlimentosPovos IndígenasEtnia Mundurukuinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALGenetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon.pdfGenetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon.pdfapplication/pdf412496https://patua.iec.gov.br/bitstreams/6cf8df86-a5f6-4a7f-8f12-2101e224efa9/downloadca3f2c455aa2388eabc9f2497791b383MD51LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Genetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon |
title |
Genetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon |
spellingShingle |
Genetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon Perini, Jamila Alessandra Mercúrio / toxicidade Sintase do Porfobilinogênio / análise Intoxicação do Sistema Nervoso por Mercúrio Polimorfismo Genético Saúde Ambiental Ingestão de Alimentos Povos Indígenas Etnia Munduruku |
title_short |
Genetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon |
title_full |
Genetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon |
title_fullStr |
Genetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon |
title_full_unstemmed |
Genetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon |
title_sort |
Genetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon |
author |
Perini, Jamila Alessandra |
author_facet |
Perini, Jamila Alessandra Silva, Mayara Calixto Vasconcellos, Ana Claudia Santiago de Viana, Paulo Victor Sousa Lima, Marcelo de Oliveira Jesus, Iracina Maura de Kempton, Joeseph William Oliveira, Rogério Adas Ayres Hacon, Sandra Souza Basta, Paulo Cesar |
author_role |
author |
author2 |
Silva, Mayara Calixto Vasconcellos, Ana Claudia Santiago de Viana, Paulo Victor Sousa Lima, Marcelo de Oliveira Jesus, Iracina Maura de Kempton, Joeseph William Oliveira, Rogério Adas Ayres Hacon, Sandra Souza Basta, Paulo Cesar |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Perini, Jamila Alessandra Silva, Mayara Calixto Vasconcellos, Ana Claudia Santiago de Viana, Paulo Victor Sousa Lima, Marcelo de Oliveira Jesus, Iracina Maura de Kempton, Joeseph William Oliveira, Rogério Adas Ayres Hacon, Sandra Souza Basta, Paulo Cesar |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Mercúrio / toxicidade Sintase do Porfobilinogênio / análise Intoxicação do Sistema Nervoso por Mercúrio Polimorfismo Genético Saúde Ambiental Ingestão de Alimentos Povos Indígenas Etnia Munduruku |
topic |
Mercúrio / toxicidade Sintase do Porfobilinogênio / análise Intoxicação do Sistema Nervoso por Mercúrio Polimorfismo Genético Saúde Ambiental Ingestão de Alimentos Povos Indígenas Etnia Munduruku |
description |
Abstract: Genetic polymorphisms involved in mercury toxicokinetics and toxicodynamics may be associated with severe mercury toxicity. This study aimed to investigate the impact of an ALAD polymorphism on chronic mercury exposure and the health situation of indigenous children from the Brazilian Amazon. One-hundred-and-three indigenous children (under 15 years old) were included and genotyped (rs1800435) using a TaqMan validated assay. The mean age was 6.6 ± 4.5 years old, 60% were female, 49% presented with anemia, and the mean hair mercury concentration was 7.0 ± 4.5 (1.4–23.9) µg/g, with 49% exceeding the reference limit (≥6.0 µg/g). Only two children were heterozygous ALAD, while the others were all wild type. Minor allele frequency (ALAD G) and heterozygous genotype (ALAD CG) were 1% and 2%, respectively. The two children (12 and 14 years old) with the ALAD polymorphism had mercury levels above the average as well as had neurological symptoms related to chronic mercury exposure, such as visual field alterations, memory deficit, distal neuropathy, and toe amyotrophy. Both children also reported frequent consumption of fish in the diet, at least three times a week. In conclusion, our data confirm that an ALAD polymorphism can contribute to mercury half-life time, harmful effects, and neuropsychological disorders in indigenous children with chronic mercury exposure to gold mining activity |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-08-30T13:35:31Z |
dc.date.available.fl_str_mv |
2021-08-30T13:35:31Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PERINI, Jamila Alessandra et al. Genetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon. International Journal of Environmental Research and Public Health, v. 18, n. 16, p. 1-12, Aug. 2021. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4431 |
dc.identifier.issn.-.fl_str_mv |
1660-4601 |
dc.identifier.doi.-.fl_str_mv |
10.3390/ijerph18168746 |
identifier_str_mv |
PERINI, Jamila Alessandra et al. Genetic polymorphism of delta aminolevulinic acid dehydratase (Alad) gene and symptoms of chronic mercury exposure in Munduruku Indigenous children within the Brazilian amazon. International Journal of Environmental Research and Public Health, v. 18, n. 16, p. 1-12, Aug. 2021. 1660-4601 10.3390/ijerph18168746 |
url |
https://patua.iec.gov.br/handle/iec/4431 |
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eng |
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eng |
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MDPI |
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MDPI |
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