Novel rodent arterivirus detected in the Brazilian Amazon
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/6837 |
Resumo: | As part of a continuous effort to investigate the viral communities associated with wild mammals at the human–animal interface in an Amazonian metropolitan region, this study describes the detection of a novel rodent-borne arterivirus. A sample containing pooled organs of Oecomys paricola was submitted to RNA sequencing, and four sequences taxonomically assigned as related to the Arteriviridae family were recovered, corresponding to an almost complete genome of nearly 13 kb summed. In the phylogenetic analysis with the standard domains used for taxa demarcation in the family, the tentatively named Oecomys arterivirus 1 (OAV-1) was placed within the clade of rodent- and porcine-associated viruses, corresponding to the Variarterivirinae subfamily. The divergence analysis, based on the same amino acid alignment, corroborated the hypothesis that the virus may represent a new genus within the subfamily. These findings contribute to the expansion of the current knowledge about the diversity, host and geographical range of the viral family. Arterivirids are non-human pathogens and are usually species-specific, but the susceptibility of cell lines derived from different organisms should be conducted to confirm these statements for this proposed new genus in an initial attempt to assess its spillover potential. |
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Paz, Thito Y. Bezerra daHernández, Leonardo Henrique AlmeidaSilva, Sandro Patroca daSilva, Fábio Silva daBarros, Bruno C. Veloso deCasseb, Livia Medeiros NevesGuimarães, Ricardo José de Paula Souza eVasconcelos, Pedro Fernando da CostaCruz, Ana Cecília Ribeiro2023-06-06T17:37:32Z2023-06-06T17:37:32Z2023PAZ, Thito Y. Bezerra da et al. Novel rodent arterivirus detected in the Brazilian Amazon. Viruses, v. 15, n. 5, p. 1-11, 2023. DOI: https://doi.org/10.3390/v15051150. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222503/pdf/viruses-15-01150.pdf1999-4915https://patua.iec.gov.br/handle/iec/683710.3390/v15051150As part of a continuous effort to investigate the viral communities associated with wild mammals at the human–animal interface in an Amazonian metropolitan region, this study describes the detection of a novel rodent-borne arterivirus. A sample containing pooled organs of Oecomys paricola was submitted to RNA sequencing, and four sequences taxonomically assigned as related to the Arteriviridae family were recovered, corresponding to an almost complete genome of nearly 13 kb summed. In the phylogenetic analysis with the standard domains used for taxa demarcation in the family, the tentatively named Oecomys arterivirus 1 (OAV-1) was placed within the clade of rodent- and porcine-associated viruses, corresponding to the Variarterivirinae subfamily. The divergence analysis, based on the same amino acid alignment, corroborated the hypothesis that the virus may represent a new genus within the subfamily. These findings contribute to the expansion of the current knowledge about the diversity, host and geographical range of the viral family. Arterivirids are non-human pathogens and are usually species-specific, but the susceptibility of cell lines derived from different organisms should be conducted to confirm these statements for this proposed new genus in an initial attempt to assess its spillover potential.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88882.449761/2019-01—CAPES) and resources conceded by Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Ministry of Health.Pará State University. Parasite Biology in the Amazon Region Graduate Program. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Pará State University. Parasite Biology in the Amazon Region Graduate Program. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratorio de Geoprocessamento. Ananindeua, PA, Brasil.Pará State University. Parasite Biology in the Amazon Region Graduate Program. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Pará State University. Parasite Biology in the Amazon Region Graduate Program. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.engMDPINovel rodent arterivirus detected in the Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleArterivirus / patogenicidadeInfecções por ArterivirusSigmodontinae / anatomia & histologiaRNA-SeqVírus de RNAinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALNovel rodent arterivirus detected in the Brazilian Amazon.pdfNovel rodent arterivirus detected in the Brazilian Amazon.pdfapplication/pdf2108475https://patua.iec.gov.br/bitstreams/8f736187-ea75-4903-80e4-fc1fd41f73b8/download0e2d60e54f194210937c2f90f1d172e6MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/aa99ce07-e21a-43de-8cef-aeae53875e60/download11832eea31b16df8613079d742d61793MD52TEXTNovel rodent arterivirus detected in the Brazilian Amazon.pdf.txtNovel rodent arterivirus detected in the Brazilian Amazon.pdf.txtExtracted texttext/plain47153https://patua.iec.gov.br/bitstreams/35aab08d-ea7a-4560-a38e-00ed2c35de02/download38b8e9bedd2bd406b25e3b726ed1e373MD53THUMBNAILNovel rodent arterivirus detected in the Brazilian Amazon.pdf.jpgNovel rodent arterivirus detected in the Brazilian Amazon.pdf.jpgGenerated Thumbnailimage/jpeg5745https://patua.iec.gov.br/bitstreams/b9fdd389-a415-4c14-96f7-383ad92098dd/downloadc4cd4f6495a1b0f68fa85f19a3c72a88MD54iec/68372023-06-06 18:15:53.696oai:patua.iec.gov.br:iec/6837https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-06-06T18:15:53Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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 |
dc.title.pt_BR.fl_str_mv |
Novel rodent arterivirus detected in the Brazilian Amazon |
title |
Novel rodent arterivirus detected in the Brazilian Amazon |
spellingShingle |
Novel rodent arterivirus detected in the Brazilian Amazon Paz, Thito Y. Bezerra da Arterivirus / patogenicidade Infecções por Arterivirus Sigmodontinae / anatomia & histologia RNA-Seq Vírus de RNA |
title_short |
Novel rodent arterivirus detected in the Brazilian Amazon |
title_full |
Novel rodent arterivirus detected in the Brazilian Amazon |
title_fullStr |
Novel rodent arterivirus detected in the Brazilian Amazon |
title_full_unstemmed |
Novel rodent arterivirus detected in the Brazilian Amazon |
title_sort |
Novel rodent arterivirus detected in the Brazilian Amazon |
author |
Paz, Thito Y. Bezerra da |
author_facet |
Paz, Thito Y. Bezerra da Hernández, Leonardo Henrique Almeida Silva, Sandro Patroca da Silva, Fábio Silva da Barros, Bruno C. Veloso de Casseb, Livia Medeiros Neves Guimarães, Ricardo José de Paula Souza e Vasconcelos, Pedro Fernando da Costa Cruz, Ana Cecília Ribeiro |
author_role |
author |
author2 |
Hernández, Leonardo Henrique Almeida Silva, Sandro Patroca da Silva, Fábio Silva da Barros, Bruno C. Veloso de Casseb, Livia Medeiros Neves Guimarães, Ricardo José de Paula Souza e Vasconcelos, Pedro Fernando da Costa Cruz, Ana Cecília Ribeiro |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Paz, Thito Y. Bezerra da Hernández, Leonardo Henrique Almeida Silva, Sandro Patroca da Silva, Fábio Silva da Barros, Bruno C. Veloso de Casseb, Livia Medeiros Neves Guimarães, Ricardo José de Paula Souza e Vasconcelos, Pedro Fernando da Costa Cruz, Ana Cecília Ribeiro |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Arterivirus / patogenicidade Infecções por Arterivirus Sigmodontinae / anatomia & histologia RNA-Seq Vírus de RNA |
topic |
Arterivirus / patogenicidade Infecções por Arterivirus Sigmodontinae / anatomia & histologia RNA-Seq Vírus de RNA |
description |
As part of a continuous effort to investigate the viral communities associated with wild mammals at the human–animal interface in an Amazonian metropolitan region, this study describes the detection of a novel rodent-borne arterivirus. A sample containing pooled organs of Oecomys paricola was submitted to RNA sequencing, and four sequences taxonomically assigned as related to the Arteriviridae family were recovered, corresponding to an almost complete genome of nearly 13 kb summed. In the phylogenetic analysis with the standard domains used for taxa demarcation in the family, the tentatively named Oecomys arterivirus 1 (OAV-1) was placed within the clade of rodent- and porcine-associated viruses, corresponding to the Variarterivirinae subfamily. The divergence analysis, based on the same amino acid alignment, corroborated the hypothesis that the virus may represent a new genus within the subfamily. These findings contribute to the expansion of the current knowledge about the diversity, host and geographical range of the viral family. Arterivirids are non-human pathogens and are usually species-specific, but the susceptibility of cell lines derived from different organisms should be conducted to confirm these statements for this proposed new genus in an initial attempt to assess its spillover potential. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-06-06T17:37:32Z |
dc.date.available.fl_str_mv |
2023-06-06T17:37:32Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PAZ, Thito Y. Bezerra da et al. Novel rodent arterivirus detected in the Brazilian Amazon. Viruses, v. 15, n. 5, p. 1-11, 2023. DOI: https://doi.org/10.3390/v15051150. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222503/pdf/viruses-15-01150.pdf |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/6837 |
dc.identifier.issn.-.fl_str_mv |
1999-4915 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.3390/v15051150 |
identifier_str_mv |
PAZ, Thito Y. Bezerra da et al. Novel rodent arterivirus detected in the Brazilian Amazon. Viruses, v. 15, n. 5, p. 1-11, 2023. DOI: https://doi.org/10.3390/v15051150. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222503/pdf/viruses-15-01150.pdf 1999-4915 10.3390/v15051150 |
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https://patua.iec.gov.br/handle/iec/6837 |
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eng |
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eng |
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MDPI |
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MDPI |
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