Leishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Shaw, Jeffrey Jon
Data de Publicação: 1975
Outros Autores: Lainson, Ralph
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/2771
Resumo: In spite of the difficulty of antigen standardization, paired intradermal skin tests demonstrated qualitative differences between leishmanin and in vitro exo-antigen. Some of these differences may be due to the destruction of certain antigens by phenol, while others seem to reflect basic antigenic differences. Leishmania mexicana amazonensis in vitro exo-antigen produced immediate anaphylactic responses in 74. 4% of the patients with parasitologically proven cutaneous leishmaniasis. Although more individuals responded to leishmanin, 82.4% as compared to 73.9%, the leishmanial in vitro exo-antigen gave significantly larger delayed responses. Trypanosoma cruzi trypamosomin elicited delayed reactions, while trypanosomal in vitro exo-antigen only produced immediate anaphylactic reactions in persons with active cutaneous leishmaniasis. Significantly more immediate anaphylactic responses were seen in L. brasiliensis guyanensis infections, and more marked responses occurred in infections of 6 months or less duration. Patients with mucocutaneous leishmaniasis had larger delayed responses than individuals with cutaneous infections due to L. b. braziliensis. Individuals with diffuse anergid cutaneous leishmaniasis had negative delayed reactions to all antigens, but two had weak anaphylactic reactions. Arthus-type responses were uncommon; they occurred in 4 people with mucocutaneous leishmaniasis, and in 3 with cutaneous leishmaniasis caused by L. b. guyanensis. No hypersensitivity reactions were seen in patients with Chagas' disease
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spelling Shaw, Jeffrey JonLainson, Ralph2017-09-28T10:28:28Z2017-09-28T10:28:28Z1975SHAW, Jeffrey Jon; LAINSON, Ralph. Leishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis. Transactions of The Royal Society of Tropical Medicine and Hygiene1975, v. 69, n. 3, p. 323-335, 1975.0035-9203https://patua.iec.gov.br/handle/iec/277110.1016/0035-9203(75)90127-3In spite of the difficulty of antigen standardization, paired intradermal skin tests demonstrated qualitative differences between leishmanin and in vitro exo-antigen. Some of these differences may be due to the destruction of certain antigens by phenol, while others seem to reflect basic antigenic differences. Leishmania mexicana amazonensis in vitro exo-antigen produced immediate anaphylactic responses in 74. 4% of the patients with parasitologically proven cutaneous leishmaniasis. Although more individuals responded to leishmanin, 82.4% as compared to 73.9%, the leishmanial in vitro exo-antigen gave significantly larger delayed responses. Trypanosoma cruzi trypamosomin elicited delayed reactions, while trypanosomal in vitro exo-antigen only produced immediate anaphylactic reactions in persons with active cutaneous leishmaniasis. Significantly more immediate anaphylactic responses were seen in L. brasiliensis guyanensis infections, and more marked responses occurred in infections of 6 months or less duration. Patients with mucocutaneous leishmaniasis had larger delayed responses than individuals with cutaneous infections due to L. b. braziliensis. Individuals with diffuse anergid cutaneous leishmaniasis had negative delayed reactions to all antigens, but two had weak anaphylactic reactions. Arthus-type responses were uncommon; they occurred in 4 people with mucocutaneous leishmaniasis, and in 3 with cutaneous leishmaniasis caused by L. b. guyanensis. No hypersensitivity reactions were seen in patients with Chagas' diseaseThese studies were conducted under the auspices of the Wellcome Trust, London, Instituto Evandro Chagas of the Fundação Instituto Oswaldo Cruz of Brazil, Fundação Serviço Especial de Saúde Pública of Brazil and the World Health Organization, Geneva.Ministério da Saúde. Fundação Serviços de Saúde Pública. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Serviços de Saúde Pública. Instituto Evandro Chagas. Belém, PA, Brasil.engOxford University PressLeishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeishmaniose / imunologiaLeishmaniose Mucocutânea / imunologiaLeishmania / imunologiaTrypanosoma cruzi / imunologiaTestes CutâneosTestes Intradérmicosinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALLeishmaniasis in Brazil: X. some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis.pdfLeishmaniasis in Brazil: X. some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis.pdfapplication/pdf3580094https://patua.iec.gov.br/bitstreams/84ba4e02-a020-456c-a32b-fe26a51998c6/downloade277a295b222e6e9514f9fb1fe9bd955MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/e9c7974e-3207-49f3-a677-28b6662a76aa/download52f1732ea66fbd1123abe39f5373b797MD52TEXTLeishmaniasis in Brazil: X. some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis.pdf.txtLeishmaniasis in Brazil: X. some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis.pdf.txtExtracted texttext/plain45317https://patua.iec.gov.br/bitstreams/47c06091-4b05-49e3-873e-87b08a424c58/download7d2a9206306bc2e5874b77e9f75d065aMD55THUMBNAILLeishmaniasis in Brazil: X. some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis.pdf.jpgLeishmaniasis in Brazil: X. some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis.pdf.jpgGenerated Thumbnailimage/jpeg8365https://patua.iec.gov.br/bitstreams/9f287495-ee08-4a6f-b1f9-2e39cd6ab535/downloadda3d39781c0e068ad349db81a4cd01edMD56iec/27712022-10-21 00:03:00.412oai:patua.iec.gov.br:iec/2771https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-21T00:03Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4=
dc.title.pt_BR.fl_str_mv Leishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis
title Leishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis
spellingShingle Leishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis
Shaw, Jeffrey Jon
Leishmaniose / imunologia
Leishmaniose Mucocutânea / imunologia
Leishmania / imunologia
Trypanosoma cruzi / imunologia
Testes Cutâneos
Testes Intradérmicos
title_short Leishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis
title_full Leishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis
title_fullStr Leishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis
title_full_unstemmed Leishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis
title_sort Leishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis
author Shaw, Jeffrey Jon
author_facet Shaw, Jeffrey Jon
Lainson, Ralph
author_role author
author2 Lainson, Ralph
author2_role author
dc.contributor.author.fl_str_mv Shaw, Jeffrey Jon
Lainson, Ralph
dc.subject.decsPrimary.pt_BR.fl_str_mv Leishmaniose / imunologia
Leishmaniose Mucocutânea / imunologia
Leishmania / imunologia
Trypanosoma cruzi / imunologia
Testes Cutâneos
Testes Intradérmicos
topic Leishmaniose / imunologia
Leishmaniose Mucocutânea / imunologia
Leishmania / imunologia
Trypanosoma cruzi / imunologia
Testes Cutâneos
Testes Intradérmicos
description In spite of the difficulty of antigen standardization, paired intradermal skin tests demonstrated qualitative differences between leishmanin and in vitro exo-antigen. Some of these differences may be due to the destruction of certain antigens by phenol, while others seem to reflect basic antigenic differences. Leishmania mexicana amazonensis in vitro exo-antigen produced immediate anaphylactic responses in 74. 4% of the patients with parasitologically proven cutaneous leishmaniasis. Although more individuals responded to leishmanin, 82.4% as compared to 73.9%, the leishmanial in vitro exo-antigen gave significantly larger delayed responses. Trypanosoma cruzi trypamosomin elicited delayed reactions, while trypanosomal in vitro exo-antigen only produced immediate anaphylactic reactions in persons with active cutaneous leishmaniasis. Significantly more immediate anaphylactic responses were seen in L. brasiliensis guyanensis infections, and more marked responses occurred in infections of 6 months or less duration. Patients with mucocutaneous leishmaniasis had larger delayed responses than individuals with cutaneous infections due to L. b. braziliensis. Individuals with diffuse anergid cutaneous leishmaniasis had negative delayed reactions to all antigens, but two had weak anaphylactic reactions. Arthus-type responses were uncommon; they occurred in 4 people with mucocutaneous leishmaniasis, and in 3 with cutaneous leishmaniasis caused by L. b. guyanensis. No hypersensitivity reactions were seen in patients with Chagas' disease
publishDate 1975
dc.date.issued.fl_str_mv 1975
dc.date.accessioned.fl_str_mv 2017-09-28T10:28:28Z
dc.date.available.fl_str_mv 2017-09-28T10:28:28Z
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dc.identifier.citation.fl_str_mv SHAW, Jeffrey Jon; LAINSON, Ralph. Leishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis. Transactions of The Royal Society of Tropical Medicine and Hygiene1975, v. 69, n. 3, p. 323-335, 1975.
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dc.identifier.doi.-.fl_str_mv 10.1016/0035-9203(75)90127-3
identifier_str_mv SHAW, Jeffrey Jon; LAINSON, Ralph. Leishmaniasis in Brazil X: some observations on intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis. Transactions of The Royal Society of Tropical Medicine and Hygiene1975, v. 69, n. 3, p. 323-335, 1975.
0035-9203
10.1016/0035-9203(75)90127-3
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