New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4092 |
Resumo: | The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi-infection in Amazonian Brazil has recently been reviewed based on the combined use of the delayed-type hypersensitivity (DTH) and indirect fluorescence antibody test (IFAT-IgG/IgM), both with homologous L. (L.) infantum chagasi-antigens, and associated with the clinical evaluation of infected individuals. This diagnostic approach has allowed to identify the broadest clinical-immunological spectrum of human L. (L.) infantum chagasi-infection composed by five clinical-immunological profiles of infection: three asymptomatic, 1) Asymptomatic Infection (AI) [DTH+/++++, IFAT−], 2) Subclinical Resistant Infection (SRI) [DTH+/++++, IFAT+/++], and 3) Indeterminate Initial Infection (III) [DTH−, IFAT+/++], and two symptomatic ones, 4) Symptomatic Infection (SI) [=American visceral leishmaniasis - AVL] and, 5) Subclinical Oligosymptomatic Infection (SOI), both with the same immune profile [DTH−, IFAT+++/++++]. Herein, we confirm for the third time the preclinical diagnosis of AVL through IgM-antibody response in an early asymptomatic case of infection (profile III), a 17-year-old boy who evolved to AVL (=profile SI) six weeks after the initial infection diagnosis, confirming that the combined use of DTH and IFAT-(IgG/IgM) assays associated with the clinical evaluation of infected individuals is potentially useful for monitoring human L. (L.) infantum chagasi-infection in endemic areas as well as optimizing AVL control. |
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Lima, Luciana Vieira do RêgoSantos, Thiago Vasconcelos dosCampos, Marliane BatistaRamos, Patrícia KarlaGomes, Claudia Maria de CastroLaurenti, Márcia DalastraMatta, Vania daCorbett, Carlos Eduardo PereiraSilveira, Fernando Tobias2020-05-26T19:14:33Z2020-05-26T19:14:33Z2020LIMA, Luciana Vieira do Rêgo et al. New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control. Parasite Epidemiology and Control, v. 10, e00154, p. 1-6, Aug. 2020.2405-6731https://patua.iec.gov.br/handle/iec/409210.1016/j.parepi.2020.e00154The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi-infection in Amazonian Brazil has recently been reviewed based on the combined use of the delayed-type hypersensitivity (DTH) and indirect fluorescence antibody test (IFAT-IgG/IgM), both with homologous L. (L.) infantum chagasi-antigens, and associated with the clinical evaluation of infected individuals. This diagnostic approach has allowed to identify the broadest clinical-immunological spectrum of human L. (L.) infantum chagasi-infection composed by five clinical-immunological profiles of infection: three asymptomatic, 1) Asymptomatic Infection (AI) [DTH+/++++, IFAT−], 2) Subclinical Resistant Infection (SRI) [DTH+/++++, IFAT+/++], and 3) Indeterminate Initial Infection (III) [DTH−, IFAT+/++], and two symptomatic ones, 4) Symptomatic Infection (SI) [=American visceral leishmaniasis - AVL] and, 5) Subclinical Oligosymptomatic Infection (SOI), both with the same immune profile [DTH−, IFAT+++/++++]. Herein, we confirm for the third time the preclinical diagnosis of AVL through IgM-antibody response in an early asymptomatic case of infection (profile III), a 17-year-old boy who evolved to AVL (=profile SI) six weeks after the initial infection diagnosis, confirming that the combined use of DTH and IFAT-(IgG/IgM) assays associated with the clinical evaluation of infected individuals is potentially useful for monitoring human L. (L.) infantum chagasi-infection in endemic areas as well as optimizing AVL control.This work was supported by Instituto Evandro Chagas (Secretaria de Vigilância em Saúde, Ministério da Saúde, Brazil); Núcleo de Medicina Tropical (Universidade Federal do Pará, Brazil); Laboratório de Investigação Médica (LIM)-50 (Hospital de ClínicasFaculdade de Medicina-Universidade de São Paulo (USP), Brazil) and, Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP: 2014/50315-0).Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.University São Paulo. Medical School. Pathology Department. São Paulo SP, Brazil.University São Paulo. Medical School. Pathology Department. São Paulo SP, Brazil.University São Paulo. Medical School. Pathology Department. São Paulo SP, Brazil.University São Paulo. Medical School. Pathology Department. São Paulo SP, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Federal University of Pará. Nucleus of Tropical Medicine. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.engElsevierNew record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease controlinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeishmaniose Visceral / patologiaLeishmaniose Visceral / parasitologiaLeishmaniose Visceral / diagnósticoControle de Doenças Transmissíveisinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALNew record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease controlpdfNew record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease controlpdfapplication/pdf487187https://patua.iec.gov.br/bitstreams/fc1b969a-6019-4e5b-a8b1-d2b1fea839d9/download4a5755a9ca6e2eb312098d52ef543f65MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/034849fc-ceae-44bc-bc99-2c393941b735/download11832eea31b16df8613079d742d61793MD52TEXTNew record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease controlpdf.txtNew record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease controlpdf.txtExtracted texttext/plain33488https://patua.iec.gov.br/bitstreams/19f6105c-7dc7-433d-af3a-e73d27c37cde/download0b6fb27ddbf8529423d38151b092a87bMD55THUMBNAILNew record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease controlpdf.jpgNew record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease controlpdf.jpgGenerated Thumbnailimage/jpeg5147https://patua.iec.gov.br/bitstreams/270fbc47-649c-490c-8b92-6496588edb87/download21d7c32e72d065ce14a10ee910bbf0f4MD56iec/40922023-04-18 12:14:15.204oai:patua.iec.gov.br:iec/4092https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-04-18T12:14:15Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv |
New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control |
title |
New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control |
spellingShingle |
New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control Lima, Luciana Vieira do Rêgo Leishmaniose Visceral / patologia Leishmaniose Visceral / parasitologia Leishmaniose Visceral / diagnóstico Controle de Doenças Transmissíveis |
title_short |
New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control |
title_full |
New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control |
title_fullStr |
New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control |
title_full_unstemmed |
New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control |
title_sort |
New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control |
author |
Lima, Luciana Vieira do Rêgo |
author_facet |
Lima, Luciana Vieira do Rêgo Santos, Thiago Vasconcelos dos Campos, Marliane Batista Ramos, Patrícia Karla Gomes, Claudia Maria de Castro Laurenti, Márcia Dalastra Matta, Vania da Corbett, Carlos Eduardo Pereira Silveira, Fernando Tobias |
author_role |
author |
author2 |
Santos, Thiago Vasconcelos dos Campos, Marliane Batista Ramos, Patrícia Karla Gomes, Claudia Maria de Castro Laurenti, Márcia Dalastra Matta, Vania da Corbett, Carlos Eduardo Pereira Silveira, Fernando Tobias |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lima, Luciana Vieira do Rêgo Santos, Thiago Vasconcelos dos Campos, Marliane Batista Ramos, Patrícia Karla Gomes, Claudia Maria de Castro Laurenti, Márcia Dalastra Matta, Vania da Corbett, Carlos Eduardo Pereira Silveira, Fernando Tobias |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Leishmaniose Visceral / patologia Leishmaniose Visceral / parasitologia Leishmaniose Visceral / diagnóstico Controle de Doenças Transmissíveis |
topic |
Leishmaniose Visceral / patologia Leishmaniose Visceral / parasitologia Leishmaniose Visceral / diagnóstico Controle de Doenças Transmissíveis |
description |
The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi-infection in Amazonian Brazil has recently been reviewed based on the combined use of the delayed-type hypersensitivity (DTH) and indirect fluorescence antibody test (IFAT-IgG/IgM), both with homologous L. (L.) infantum chagasi-antigens, and associated with the clinical evaluation of infected individuals. This diagnostic approach has allowed to identify the broadest clinical-immunological spectrum of human L. (L.) infantum chagasi-infection composed by five clinical-immunological profiles of infection: three asymptomatic, 1) Asymptomatic Infection (AI) [DTH+/++++, IFAT−], 2) Subclinical Resistant Infection (SRI) [DTH+/++++, IFAT+/++], and 3) Indeterminate Initial Infection (III) [DTH−, IFAT+/++], and two symptomatic ones, 4) Symptomatic Infection (SI) [=American visceral leishmaniasis - AVL] and, 5) Subclinical Oligosymptomatic Infection (SOI), both with the same immune profile [DTH−, IFAT+++/++++]. Herein, we confirm for the third time the preclinical diagnosis of AVL through IgM-antibody response in an early asymptomatic case of infection (profile III), a 17-year-old boy who evolved to AVL (=profile SI) six weeks after the initial infection diagnosis, confirming that the combined use of DTH and IFAT-(IgG/IgM) assays associated with the clinical evaluation of infected individuals is potentially useful for monitoring human L. (L.) infantum chagasi-infection in endemic areas as well as optimizing AVL control. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-05-26T19:14:33Z |
dc.date.available.fl_str_mv |
2020-05-26T19:14:33Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LIMA, Luciana Vieira do Rêgo et al. New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control. Parasite Epidemiology and Control, v. 10, e00154, p. 1-6, Aug. 2020. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4092 |
dc.identifier.issn.-.fl_str_mv |
2405-6731 |
dc.identifier.doi.-.fl_str_mv |
10.1016/j.parepi.2020.e00154 |
identifier_str_mv |
LIMA, Luciana Vieira do Rêgo et al. New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control. Parasite Epidemiology and Control, v. 10, e00154, p. 1-6, Aug. 2020. 2405-6731 10.1016/j.parepi.2020.e00154 |
url |
https://patua.iec.gov.br/handle/iec/4092 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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