First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil

Detalhes bibliográficos
Autor(a) principal: Santos, Anderson Lineu Siqueira dos
Data de Publicação: 2020
Outros Autores: Rodrigues, Yan Corrêa, Melo, Marcos Vinícios Hino de, Santos, Pabllo Antonny Silva dos, Oliveira, Tatyellen Natasha da Costa, Sardinha, Daniele Melo, Lima, Luana Nepomuceno Gondim Costa, Brasiliense, Danielle Murici, Lima, Karla Valéria Batista
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: http://patua.iec.gov.br//handle/iec/4221
Resumo: Abstract: Klebsiella pneumoniae appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by K. pneumoniae in cancer patients treated at an oncology referral center in the state of Pará, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational, cross-sectional study, with a descriptive and analytical approach was conducted, including patients with confirmed diagnosis of cancer who acquired infection by K. pneumoniae 72 h after hospital admission. K. pneumoniae isolates included in the study were obtained from different clinical materials (blood, urine, catheter tip and bladder catheter, orotracheal secretions, oncological and surgical wounds). Antimicrobial susceptibility testing and molecular detection of the carbapenemase-encoding genes were performed. A high prevalence of MDR K. pneumoniae isolates was observed, including two colistin-resistant isolates and seven isolates harboring blaKPC-1 gene. To conclude, our findings provide the firsts insights into the epidemiology and infection by K. pneumoniae in the state of Pará, Brazil, and may be useful on treatment guidance and establishment of strategies to control the spread of resistance strains of K. pneumoniae in the region.
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spelling Santos, Anderson Lineu Siqueira dosRodrigues, Yan CorrêaMelo, Marcos Vinícios Hino deSantos, Pabllo Antonny Silva dosOliveira, Tatyellen Natasha da CostaSardinha, Daniele MeloLima, Luana Nepomuceno Gondim CostaBrasiliense, Danielle MuriciLima, Karla Valéria Batista2021-01-26T12:22:00Z2021-01-26T12:22:00Z2020SANTOS, Anderson Lineu Siqueira dos et al. First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil. Infectious Disease Reports, v. 12, n. 3, p. 110-120, Dec. 2020.2036-7449http://patua.iec.gov.br//handle/iec/422110.3390/idr12030021Abstract: Klebsiella pneumoniae appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by K. pneumoniae in cancer patients treated at an oncology referral center in the state of Pará, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational, cross-sectional study, with a descriptive and analytical approach was conducted, including patients with confirmed diagnosis of cancer who acquired infection by K. pneumoniae 72 h after hospital admission. K. pneumoniae isolates included in the study were obtained from different clinical materials (blood, urine, catheter tip and bladder catheter, orotracheal secretions, oncological and surgical wounds). Antimicrobial susceptibility testing and molecular detection of the carbapenemase-encoding genes were performed. A high prevalence of MDR K. pneumoniae isolates was observed, including two colistin-resistant isolates and seven isolates harboring blaKPC-1 gene. To conclude, our findings provide the firsts insights into the epidemiology and infection by K. pneumoniae in the state of Pará, Brazil, and may be useful on treatment guidance and establishment of strategies to control the spread of resistance strains of K. pneumoniae in the region.This research was supported by funding from the Fundação de Amparo à Pesquisa do Pará/Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (FAPESPA/CAPES) [Cooperation grant Nº017/2014], Programa Institucional de Bolsas de Iniciação Científica/Fundação Amazônia Paraense de Amparo à Pesquisa/Universidade do Estado do Pará (FAPESPA/UEPA) [Cooperation grant Nº001/2017/PPGBPA], Fundação de Amparo à Pesquisa do Pará/Universidade do Estado do Pará (FAPESPA/UEPA) [Cooperation grant Nº004/2019] and the Instituto Evandro Chagas/Ministério da Saúde/Secretaria de Vigilância em Saúde (IEC/MS/SVS)State University of Pará. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Belém, PA, Brasil.State University of Pará. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Belém, PA, Brasil.State University of Pará. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Belém, PA, Brasil.State University of Pará. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Belém, PA, Brasil.State University of Pará. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Pós- Graduação em Epidemiologia e Vigilância em Saúde. Ananindeua, PA, Brasil.State University of Pará. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Belém, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.State University of Pará. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Belém, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.engMDPIFirst insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNeoplasias / patologiaKlebsiella pneumoniae / patogenicidadeInfecções por Klebsiella / microbiologiaResistência a Múltiplos Medicamentosinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALFirst insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil.pdfFirst insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil.pdfapplication/pdf295486https://patua.iec.gov.br/bitstreams/0035764c-0137-498b-8396-aa6499259735/download5b818cf30055da417d322e55ff80c407MD51LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil
title First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil
spellingShingle First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil
Santos, Anderson Lineu Siqueira dos
Neoplasias / patologia
Klebsiella pneumoniae / patogenicidade
Infecções por Klebsiella / microbiologia
Resistência a Múltiplos Medicamentos
title_short First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil
title_full First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil
title_fullStr First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil
title_full_unstemmed First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil
title_sort First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil
author Santos, Anderson Lineu Siqueira dos
author_facet Santos, Anderson Lineu Siqueira dos
Rodrigues, Yan Corrêa
Melo, Marcos Vinícios Hino de
Santos, Pabllo Antonny Silva dos
Oliveira, Tatyellen Natasha da Costa
Sardinha, Daniele Melo
Lima, Luana Nepomuceno Gondim Costa
Brasiliense, Danielle Murici
Lima, Karla Valéria Batista
author_role author
author2 Rodrigues, Yan Corrêa
Melo, Marcos Vinícios Hino de
Santos, Pabllo Antonny Silva dos
Oliveira, Tatyellen Natasha da Costa
Sardinha, Daniele Melo
Lima, Luana Nepomuceno Gondim Costa
Brasiliense, Danielle Murici
Lima, Karla Valéria Batista
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Anderson Lineu Siqueira dos
Rodrigues, Yan Corrêa
Melo, Marcos Vinícios Hino de
Santos, Pabllo Antonny Silva dos
Oliveira, Tatyellen Natasha da Costa
Sardinha, Daniele Melo
Lima, Luana Nepomuceno Gondim Costa
Brasiliense, Danielle Murici
Lima, Karla Valéria Batista
dc.subject.decsPrimary.pt_BR.fl_str_mv Neoplasias / patologia
Klebsiella pneumoniae / patogenicidade
Infecções por Klebsiella / microbiologia
Resistência a Múltiplos Medicamentos
topic Neoplasias / patologia
Klebsiella pneumoniae / patogenicidade
Infecções por Klebsiella / microbiologia
Resistência a Múltiplos Medicamentos
description Abstract: Klebsiella pneumoniae appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by K. pneumoniae in cancer patients treated at an oncology referral center in the state of Pará, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational, cross-sectional study, with a descriptive and analytical approach was conducted, including patients with confirmed diagnosis of cancer who acquired infection by K. pneumoniae 72 h after hospital admission. K. pneumoniae isolates included in the study were obtained from different clinical materials (blood, urine, catheter tip and bladder catheter, orotracheal secretions, oncological and surgical wounds). Antimicrobial susceptibility testing and molecular detection of the carbapenemase-encoding genes were performed. A high prevalence of MDR K. pneumoniae isolates was observed, including two colistin-resistant isolates and seven isolates harboring blaKPC-1 gene. To conclude, our findings provide the firsts insights into the epidemiology and infection by K. pneumoniae in the state of Pará, Brazil, and may be useful on treatment guidance and establishment of strategies to control the spread of resistance strains of K. pneumoniae in the region.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-01-26T12:22:00Z
dc.date.available.fl_str_mv 2021-01-26T12:22:00Z
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dc.identifier.citation.fl_str_mv SANTOS, Anderson Lineu Siqueira dos et al. First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil. Infectious Disease Reports, v. 12, n. 3, p. 110-120, Dec. 2020.
dc.identifier.uri.fl_str_mv http://patua.iec.gov.br//handle/iec/4221
dc.identifier.issn.-.fl_str_mv 2036-7449
dc.identifier.doi.-.fl_str_mv 10.3390/idr12030021
identifier_str_mv SANTOS, Anderson Lineu Siqueira dos et al. First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil. Infectious Disease Reports, v. 12, n. 3, p. 110-120, Dec. 2020.
2036-7449
10.3390/idr12030021
url http://patua.iec.gov.br//handle/iec/4221
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