Genomic and epidemiological surveillance of Zika virus in the Amazon region

• Autor(a) principal: Giovanetti, Marta
• Data de Publicação: 2020
• Outros Autores: Faria, Nuno Rodrigues, Lourenço, José, Jesus, Jaqueline Goes de, Xavier, Joilson, Claro, Ingra Morales, Kraemer, Moritz U. G, Fonseca, Vagner, Dellicour, Simon, Théze, Julien, Salles, Flavia da Silva, Graf, Tiago, Silveira, Paola Paz, Nascimento, Valdinete Alves do, Souza, Victor Costa de, Iani, Felipe Campos de Melo, Martins, Emerson Augusto Castilho, Cruz, Laura Nogueira, Wallau, Gabriel, Fabri, Allison, Levy, Flávia, Quick, Joshua, Azevedo, Vasco de, Aguiar, Renato Santana de, Oliveira, Tulio de, Menezes, Camila Bôtto de, Castilho, Marcia da Costa, Terra, Tirza Matos, Silva, Marineide Souza da, Filippis, Ana Maria Bispo de, Abreu, André Luiz de, Oliveira, Wanderson Kleber, Croda, Julio, Albuquerque, Carlos Frederico Campelo de, Nunes, Márcio Roberto Teixeira, Sabino, Ester Cerdeira, Loman, Nicholas, Naveca, Felipe Gomes, Pybus, Oliver G, Alcantara, Luiz Carlos Júnior
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/4067
• topic: Zika virus / patogenicidade; Zika virus / isolamento & purificação; Infecção por Zika virus / transmissão; Infecção por Zika virus / genética; Surtos de Doenças; Manaus (AM)

Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, in terms of both transmission and viral genetic diversity. Using portable virus genome sequencing, we generated 59 ZIKV genomes in Manaus. Phylogenetic analyses indicated multiple introductions of ZIKV from northeastern Brazil to Manaus. Spatial genomic analysis of virus movement among six areas in Manaus suggested that populous northern neighborhoods acted as sources of virus transmission to other neighborhoods. Our study revealed how the ZIKV epidemic was ignited and maintained within the largest urban metropolis in the Amazon. These results might contribute to improving the public health response to outbreaks in Brazil.