Lack of Arg972 polymorphism in the IRS1 gene in Parakanã brazilian indians

• Autor(a) principal: Bezerra, Rosângela M. N
• Data de Publicação: 2004
• Outros Autores: Chadid, Thiago T, Altemani, Cláudia M, Sales, Teresa S. I, Menezes, Raimundo, Soares, Manoel do Carmo Pereira, Saad, Sara T. O, Saad, Mario J. A
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/458
• topic: Polimorfismo Genético; Receptor de Insulina; Resistência à Insulina

Several polymorphisms in the insulin receptor substrate-I (IRS I) gene have been reported in the last years. The most common IRSI variant, a Gly -cArg substitution at codon 972 (Arg972 IRS I). is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations. To determine whether the absence of IRS I polymorphism is a more general characteristic of Paleo-Indian-derived populations, we examined the Arg972 IRSI polymorphism in Parakan5t Indians and found a lack of this polymorphism in the Parakana population.