Effect of age and sex on bone markers in Chlorocebus aethiops raised in captivity

• Autor(a) principal: Imbeloni, Aline Amaral
• Data de Publicação: 2016
• Outros Autores: Rahal, Sheila Canavese, Silva Filho, Ednaldo da, Faria, Bianca Mendonça, Silva, Wellington Bandeira da, Oliveira, Karol Guimarães, Aihara, Mika Ester, Monteiro, Frederico Ozanan Barros
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/4016
• topic: Primatas / anatomia & histologia; Cercopithecinae / anatomia & histologia; Biomarcadores / análise; Reabsorção Óssea / veterinária

The objective was to evaluate the procollagen type I N-propeptide (PINP), osteocalcin (OC), β-crosslaps (β-CTX), and parathyroid hormone (PTH) in relation to age and sex of Chlorocebus aethiops in captivity. METHODS: Seventy-three monkeys were divided into four age groups: AG1 (juvenile); AG2 (young adult); AG3 (adult); and AG4 (senile). An electrochemiluminescence immunoassay with an Elecsys 2010 analyzer was used to determine the serum markers of bone. RESULTS AND CONCLUSIONS: Sex did not influence the results of the markers. However, the variables PINP, OC, and β-CTX were negatively correlated with age (r = -0.643; r = -0.711; r = -0.488; P < 0.001, respectively), and PTH was correlated positively with age (r = 0.418, P < 0.001). The data obtained can be used as biomarkers of bone metabolism reference intervals in healthy C. aethiops in captivity.