Serological and molecular retrospective analysis of hepatitis E suspected cases from the Eastern Brazilian Amazon 1993-2014

• Autor(a) principal: Souza, Alex Junior Souza de
• Data de Publicação: 2019
• Outros Autores: Malheiros, Andreza Pinheiro, Sarmento, Vânia Pinto, Resende, Fabricio de Souza, Alves, Max Moreira, Nunes, Heloisa Marceliano, Soares, Manoel do Carmo Pereira, Sá, Lilian Rose Marques de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/3717
• topic: Hepatite E / patologia; Hepatite E / epidemiologia; Sorologia / métodos; Vírus de Hepatite; Amazônia Oriental Brasileira

Introduction: We evaluated the anti-hepatitis E virus (HEV) antibody prevalence and HEV-RNA in archived serum samples of non-A–C hepatitis, or suspected cases of HEV infection from the Eastern Brazilian Amazon from 1993 to 2014. Methods: Serum samples (n = 318) were tested using ELISA and immunoblotting, and screened for HEV-RNA by RT-qPCR. Results: Anti-HEV IgM and IgG were detected in 3.4% (11/318) and 5.9% (19/318) of the samples, respectively. All samples were HEV-RNA negative. Conclusions: HEV was detected at a low prevalence. Broader serological and molecular evaluation of HEV infection in the Amazon region should be carried out.