The innate immune response in Zika virus infection

Detalhes bibliográficos
Autor(a) principal: Sousa, Jorge Rodrigues de
Data de Publicação: 2020
Outros Autores: Azevedo, Raimunda do Socorro da Silva, Quaresma, Juarez Antônio Simões, Vasconcelos, Pedro Fernando da Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: http://patua.iec.gov.br//handle/iec/4180
Resumo: Zika virus (ZIKV; Flaviviridae, Flavivirus) was discovered in 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey (Macaca mulatta). It is an enveloped, positive‐sense, single‐stranded RNA virus, which encodes a single polyprotein that is cleaved into 10 individual proteins. In 2015, the Zika‐epidemic in Brazil was marked mainly by the exponential growth of microcephaly cases and other congenital defects. With regard to host–pathogen relationships, understanding the role of the immune response in the pathogenesis ZIKV infection is challenging. The innate immune response is the first‐line immunological defence, in which pathogen‐associated molecular patterns are recognized by pattern‐recognition receptors that trigger macrophages, dendritic cells, natural killer cells and endothelial cells to produce several mediators, which modulate viral replication and immune evasion. In this review, we have summarized current knowledge on the innate immune response against ZIKV.
id IEC-2_7924727ef800d273999e562ea333375b
oai_identifier_str oai:patua.iec.gov.br:iec/4180
network_acronym_str IEC-2
network_name_str Repositório Digital do Instituto Evandro Chagas (Patuá)
repository_id_str
spelling Sousa, Jorge Rodrigues deAzevedo, Raimunda do Socorro da SilvaQuaresma, Juarez Antônio SimõesVasconcelos, Pedro Fernando da Costa2020-10-13T14:01:39Z2020-10-13T14:01:39Z2020SOUSA, Jorge Rodrigues de et al. The innate immune response in Zika virus infection. Reviews in Medical Virology, v. 31, n. 2, e2166, p. xx, Mar. 2021.1052-9276http://patua.iec.gov.br//handle/iec/418010.1002/rmv.2166Zika virus (ZIKV; Flaviviridae, Flavivirus) was discovered in 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey (Macaca mulatta). It is an enveloped, positive‐sense, single‐stranded RNA virus, which encodes a single polyprotein that is cleaved into 10 individual proteins. In 2015, the Zika‐epidemic in Brazil was marked mainly by the exponential growth of microcephaly cases and other congenital defects. With regard to host–pathogen relationships, understanding the role of the immune response in the pathogenesis ZIKV infection is challenging. The innate immune response is the first‐line immunological defence, in which pathogen‐associated molecular patterns are recognized by pattern‐recognition receptors that trigger macrophages, dendritic cells, natural killer cells and endothelial cells to produce several mediators, which modulate viral replication and immune evasion. In this review, we have summarized current knowledge on the innate immune response against ZIKV.CAPES ; National Council for Scientific and Technological Development (CNPq) 303999/2016-0; 439971/2016-0; 440405/2016-5Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Universidade do Estado do Pará. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Universidade do Estado do Pará. Belém, PA, Brazil / Universidade Federal do Pará. Núcleo de Medicina Tropical. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Universidade do Estado do Pará. Belém, PA, Brazil.engWileyThe innate immune response in Zika virus infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleZika virus / patogenicidadeInfecção por Zika virus / imunologiaCitocinasInterações Hospedeiro-Patógeno / imunologiainfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALThe innate immune response in Zika virus infection.pdfThe innate immune response in Zika virus infection.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/c1ccd063-ebd4-4d28-9e8c-729207ed39eb/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/5d86ec88-9531-4abf-b5c4-6ecf45498827/download11832eea31b16df8613079d742d61793MD52TEXTThe innate immune response in Zika virus infection.pdf.txtThe innate immune response in Zika virus infection.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/a2ade6fd-4361-4cb8-ba97-8e995f126e70/downloade1c06d85ae7b8b032bef47e42e4c08f9MD55THUMBNAILThe innate immune response in Zika virus infection.pdf.jpgThe innate immune response in Zika virus infection.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/b9b77cb4-dc91-4e45-b55a-6c9beea11d58/download71859d578212107f7f8c49a4ce09d9eeMD56iec/41802022-10-21 00:18:27.427oai:patua.iec.gov.br:iec/4180https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-21T00:18:27Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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
dc.title.pt_BR.fl_str_mv The innate immune response in Zika virus infection
title The innate immune response in Zika virus infection
spellingShingle The innate immune response in Zika virus infection
Sousa, Jorge Rodrigues de
Zika virus / patogenicidade
Infecção por Zika virus / imunologia
Citocinas
Interações Hospedeiro-Patógeno / imunologia
title_short The innate immune response in Zika virus infection
title_full The innate immune response in Zika virus infection
title_fullStr The innate immune response in Zika virus infection
title_full_unstemmed The innate immune response in Zika virus infection
title_sort The innate immune response in Zika virus infection
author Sousa, Jorge Rodrigues de
author_facet Sousa, Jorge Rodrigues de
Azevedo, Raimunda do Socorro da Silva
Quaresma, Juarez Antônio Simões
Vasconcelos, Pedro Fernando da Costa
author_role author
author2 Azevedo, Raimunda do Socorro da Silva
Quaresma, Juarez Antônio Simões
Vasconcelos, Pedro Fernando da Costa
author2_role author
author
author
dc.contributor.author.fl_str_mv Sousa, Jorge Rodrigues de
Azevedo, Raimunda do Socorro da Silva
Quaresma, Juarez Antônio Simões
Vasconcelos, Pedro Fernando da Costa
dc.subject.decsPrimary.pt_BR.fl_str_mv Zika virus / patogenicidade
Infecção por Zika virus / imunologia
Citocinas
Interações Hospedeiro-Patógeno / imunologia
topic Zika virus / patogenicidade
Infecção por Zika virus / imunologia
Citocinas
Interações Hospedeiro-Patógeno / imunologia
description Zika virus (ZIKV; Flaviviridae, Flavivirus) was discovered in 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey (Macaca mulatta). It is an enveloped, positive‐sense, single‐stranded RNA virus, which encodes a single polyprotein that is cleaved into 10 individual proteins. In 2015, the Zika‐epidemic in Brazil was marked mainly by the exponential growth of microcephaly cases and other congenital defects. With regard to host–pathogen relationships, understanding the role of the immune response in the pathogenesis ZIKV infection is challenging. The innate immune response is the first‐line immunological defence, in which pathogen‐associated molecular patterns are recognized by pattern‐recognition receptors that trigger macrophages, dendritic cells, natural killer cells and endothelial cells to produce several mediators, which modulate viral replication and immune evasion. In this review, we have summarized current knowledge on the innate immune response against ZIKV.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-10-13T14:01:39Z
dc.date.available.fl_str_mv 2020-10-13T14:01:39Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUSA, Jorge Rodrigues de et al. The innate immune response in Zika virus infection. Reviews in Medical Virology, v. 31, n. 2, e2166, p. xx, Mar. 2021.
dc.identifier.uri.fl_str_mv http://patua.iec.gov.br//handle/iec/4180
dc.identifier.issn.-.fl_str_mv 1052-9276
dc.identifier.doi.-.fl_str_mv 10.1002/rmv.2166
identifier_str_mv SOUSA, Jorge Rodrigues de et al. The innate immune response in Zika virus infection. Reviews in Medical Virology, v. 31, n. 2, e2166, p. xx, Mar. 2021.
1052-9276
10.1002/rmv.2166
url http://patua.iec.gov.br//handle/iec/4180
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Digital do Instituto Evandro Chagas (Patuá)
instname:Instituto Evandro Chagas (IEC)
instacron:IEC
instname_str Instituto Evandro Chagas (IEC)
instacron_str IEC
institution IEC
reponame_str Repositório Digital do Instituto Evandro Chagas (Patuá)
collection Repositório Digital do Instituto Evandro Chagas (Patuá)
bitstream.url.fl_str_mv https://patua.iec.gov.br/bitstreams/c1ccd063-ebd4-4d28-9e8c-729207ed39eb/download
https://patua.iec.gov.br/bitstreams/5d86ec88-9531-4abf-b5c4-6ecf45498827/download
https://patua.iec.gov.br/bitstreams/a2ade6fd-4361-4cb8-ba97-8e995f126e70/download
https://patua.iec.gov.br/bitstreams/b9b77cb4-dc91-4e45-b55a-6c9beea11d58/download
bitstream.checksum.fl_str_mv c9a9c128e29cac82a5d7fdf3f4e6da73
11832eea31b16df8613079d742d61793
e1c06d85ae7b8b032bef47e42e4c08f9
71859d578212107f7f8c49a4ce09d9ee
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)
repository.mail.fl_str_mv clariceneta@iec.gov.br || Biblioteca@iec.gov.br
_version_ 1809190057525903360