Repeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/6670 |
Resumo: | Alcohol consumption is spread worldwide and can lead to an abuse profile associated with severe health problems. Adolescents are more susceptible to addiction and usually consume ethanol in a binge drinking pattern. This form of consumption can lead to cognitive and emotional disorders, however scarce studies have focused on long-term hazardous effects following withdrawal periods after binge drinking in adolescents. Thus, the present study aims at investigating whether behavioral and cognitive changes persist until mid and late adulthood. Female Wistar rats (9-10 animals/group) received intragastric administration of four cycles of ethanol binge-like pattern (3.0 g/kg/day, 20% w/v; 3 days-on/4 days-off) from 35th to 58th days old, followed withdrawal checkpoints 1 day, 30 days, and 60 days. At each checkpoint period, behavioral tests of open field, object recognition test, elevated plus maze, and forced swimming test were performed, and blood and hippocampus were collected for oxidative biochemistry and brain-derived neurotrophic factor (BDNF) levels analysis, respectively. The results demonstrated that adolescent rats exposed to binge drinking displayed anxiogenic- and depressive-like phenotype in early and midadulthood, however, anxiety-like profile persisted until late adulthood. Similarly, short-term memory was impaired in all withdrawal periods analysed, including late adult life. These behavioral data were associated with oxidative damage in midadulthood but not BDNF alterations. Taken together, the present work highlights the long-lasting emotional and cognitive alterations induced by ethanol binge drinking during adolescence, even after a long period of abstinence, which might impact adult life. |
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Queiroz, Letícia YoshitomeOliveira, Igor Gonçalves deCartágenes, Sabrina de CarvalhoFernandes, Luanna Melo PereiraSantos, Sávio Monteiro dosFerreira, Wallax Augusto SilvaMello Junior, Fernando Augusto RodriguesBittencourt, Leonardo OliveiraPaiva, Edson Bruno CamposBurbano, Rommel Mario RodríguezOliveira, Edivaldo Herculano Corrêa deMonteiro, Marta ChagasFontes Júnior, Enéas AndradeMaia, Cristiane do Socorro FerrazLima, Rafael Rodrigues2022-11-21T14:43:06Z2022-11-21T14:43:06Z2022QUEIROZ, Letícia Yoshitome et al. Repeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats. Oxidative Medicine and Cellular Longevity, v. 2022, article ID 7207755, p 1-11, Oct. 2022. DOI: https://doi.org/10.1155/2022/7207755. Disponível em: https://downloads.hindawi.com/journals/omcl/2022/7207755.pdf.1942-0994https://patua.iec.gov.br/handle/iec/667010.1155/2022/7207755Alcohol consumption is spread worldwide and can lead to an abuse profile associated with severe health problems. Adolescents are more susceptible to addiction and usually consume ethanol in a binge drinking pattern. This form of consumption can lead to cognitive and emotional disorders, however scarce studies have focused on long-term hazardous effects following withdrawal periods after binge drinking in adolescents. Thus, the present study aims at investigating whether behavioral and cognitive changes persist until mid and late adulthood. Female Wistar rats (9-10 animals/group) received intragastric administration of four cycles of ethanol binge-like pattern (3.0 g/kg/day, 20% w/v; 3 days-on/4 days-off) from 35th to 58th days old, followed withdrawal checkpoints 1 day, 30 days, and 60 days. At each checkpoint period, behavioral tests of open field, object recognition test, elevated plus maze, and forced swimming test were performed, and blood and hippocampus were collected for oxidative biochemistry and brain-derived neurotrophic factor (BDNF) levels analysis, respectively. The results demonstrated that adolescent rats exposed to binge drinking displayed anxiogenic- and depressive-like phenotype in early and midadulthood, however, anxiety-like profile persisted until late adulthood. Similarly, short-term memory was impaired in all withdrawal periods analysed, including late adult life. These behavioral data were associated with oxidative damage in midadulthood but not BDNF alterations. Taken together, the present work highlights the long-lasting emotional and cognitive alterations induced by ethanol binge drinking during adolescence, even after a long period of abstinence, which might impact adult life.This work was funded by a Research Productivity Grant awarded to Dr. Cristiane do Socorro Ferraz Maia (grant number 311335/2019-5), Dr. Rafael Rodrigues, and Dr. Rommel Burbano by the Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq/Brazil, and by the Research Pro-Rectory of the Federal University of Pará (PROPESP, UFPA, Brazil), which provided the article publication feeFederal University of Pará. Institute of Health Science. Faculty of Pharmacy. Laboratory of Pharmacology of Inflammation and Behavior. Belém, PA, Brazil.Federal University of Pará. Institute of Health Science. Faculty of Pharmacy. Laboratory of Pharmacology of Inflammation and Behavior. Belém, PA, Brazil / Federal University of Pará. Institute of Health Science. Program of Post-Graduation of Pharmaceutical Science. Belém, PA, Brazil.Federal University of Pará. Institute of Health Science. Faculty of Pharmacy. Laboratory of Pharmacology of Inflammation and Behavior. Belém, PA, Brazil.Federal University of Pará. Institute of Health Science. Faculty of Pharmacy. Laboratory of Pharmacology of Inflammation and Behavior. Belém, PA, Brazil / State University of Pará. Biological and Health Science Centre. Physiological and Morphological Sciences Department. Belém, PA, Brazil.Federal University of Pará. Institute of Health Science. Program of Post-Graduation of Pharmaceutical Science. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Faculty of Pharmacy. Laboratory of In Vitro Assays, Immunology and Microbiology. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos. Instituto Evandro Chagas. Laboratório de Citogenômica e Mutagênese Ambiental. Ananindeua, PA, Brasil / Federal University of Pará. Institute of Exact and Natural Sciences. Faculty of Natural Sciences. Belém, PA, Brasil.Ophir Loyola Hospital. Laboratory of Molecular Biology. Belém, PA, Brazil.Federal University of Pará. Biological Science Institute. Laboratory of Functional and Structural Biology. Belém, PA, Brazil.Federal University of Western Pará. Santarém, PA, Brazil.Ophir Loyola Hospital. Laboratory of Molecular Biology. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos. Instituto Evandro Chagas. Laboratório de Citogenômica e Mutagênese Ambiental. Ananindeua, PA, Brasil / Federal University of Pará. Institute of Exact and Natural Sciences. Faculty of Natural Sciences. Belém, PA, Brasil.Federal University of Pará. Institute of Health Science. Program of Post-Graduation of Pharmaceutical Science. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Faculty of Pharmacy. Laboratory of In Vitro Assays, Immunology and Microbiology. Belém, PA, Brazil.Federal University of Pará. Biological Science Institute. Laboratory of Functional and Structural Biology. Belém, PA, Brazil.Federal University of Pará. Institute of Health Science. Faculty of Pharmacy. Laboratory of Pharmacology of Inflammation and Behavior. Belém, PA, Brazil / Federal University of Pará. Institute of Health Science. Program of Post-Graduation of Pharmaceutical Science. Belém, PA, Brazil.Federal University of Pará. Institute of Health Science. Faculty of Pharmacy. Laboratory of Pharmacology of Inflammation and Behavior. Belém, PA, Brazil / Federal University of Pará. Institute of Health Science. Program of Post-Graduation of Pharmaceutical Science. Belém, PA, Brazil.engHindawiRepeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRatos Wistar / anatomia & histologiaConsumo de Bebidas AlcoólicasTranstornos Relacionados ao Uso de ÁlcoolAbstinência de ÁlcoolComportamento / fisiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALRepeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats.pdfRepeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats.pdfapplication/pdf1105542https://patua.iec.gov.br/bitstreams/42fc8901-87c0-4d26-a291-1faf8900e367/downloadf35adea3b368b2e2cce7b6909a764949MD51LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Repeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats |
title |
Repeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats |
spellingShingle |
Repeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats Queiroz, Letícia Yoshitome Ratos Wistar / anatomia & histologia Consumo de Bebidas Alcoólicas Transtornos Relacionados ao Uso de Álcool Abstinência de Álcool Comportamento / fisiologia |
title_short |
Repeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats |
title_full |
Repeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats |
title_fullStr |
Repeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats |
title_full_unstemmed |
Repeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats |
title_sort |
Repeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats |
author |
Queiroz, Letícia Yoshitome |
author_facet |
Queiroz, Letícia Yoshitome Oliveira, Igor Gonçalves de Cartágenes, Sabrina de Carvalho Fernandes, Luanna Melo Pereira Santos, Sávio Monteiro dos Ferreira, Wallax Augusto Silva Mello Junior, Fernando Augusto Rodrigues Bittencourt, Leonardo Oliveira Paiva, Edson Bruno Campos Burbano, Rommel Mario Rodríguez Oliveira, Edivaldo Herculano Corrêa de Monteiro, Marta Chagas Fontes Júnior, Enéas Andrade Maia, Cristiane do Socorro Ferraz Lima, Rafael Rodrigues |
author_role |
author |
author2 |
Oliveira, Igor Gonçalves de Cartágenes, Sabrina de Carvalho Fernandes, Luanna Melo Pereira Santos, Sávio Monteiro dos Ferreira, Wallax Augusto Silva Mello Junior, Fernando Augusto Rodrigues Bittencourt, Leonardo Oliveira Paiva, Edson Bruno Campos Burbano, Rommel Mario Rodríguez Oliveira, Edivaldo Herculano Corrêa de Monteiro, Marta Chagas Fontes Júnior, Enéas Andrade Maia, Cristiane do Socorro Ferraz Lima, Rafael Rodrigues |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Queiroz, Letícia Yoshitome Oliveira, Igor Gonçalves de Cartágenes, Sabrina de Carvalho Fernandes, Luanna Melo Pereira Santos, Sávio Monteiro dos Ferreira, Wallax Augusto Silva Mello Junior, Fernando Augusto Rodrigues Bittencourt, Leonardo Oliveira Paiva, Edson Bruno Campos Burbano, Rommel Mario Rodríguez Oliveira, Edivaldo Herculano Corrêa de Monteiro, Marta Chagas Fontes Júnior, Enéas Andrade Maia, Cristiane do Socorro Ferraz Lima, Rafael Rodrigues |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Ratos Wistar / anatomia & histologia Consumo de Bebidas Alcoólicas Transtornos Relacionados ao Uso de Álcool Abstinência de Álcool Comportamento / fisiologia |
topic |
Ratos Wistar / anatomia & histologia Consumo de Bebidas Alcoólicas Transtornos Relacionados ao Uso de Álcool Abstinência de Álcool Comportamento / fisiologia |
description |
Alcohol consumption is spread worldwide and can lead to an abuse profile associated with severe health problems. Adolescents are more susceptible to addiction and usually consume ethanol in a binge drinking pattern. This form of consumption can lead to cognitive and emotional disorders, however scarce studies have focused on long-term hazardous effects following withdrawal periods after binge drinking in adolescents. Thus, the present study aims at investigating whether behavioral and cognitive changes persist until mid and late adulthood. Female Wistar rats (9-10 animals/group) received intragastric administration of four cycles of ethanol binge-like pattern (3.0 g/kg/day, 20% w/v; 3 days-on/4 days-off) from 35th to 58th days old, followed withdrawal checkpoints 1 day, 30 days, and 60 days. At each checkpoint period, behavioral tests of open field, object recognition test, elevated plus maze, and forced swimming test were performed, and blood and hippocampus were collected for oxidative biochemistry and brain-derived neurotrophic factor (BDNF) levels analysis, respectively. The results demonstrated that adolescent rats exposed to binge drinking displayed anxiogenic- and depressive-like phenotype in early and midadulthood, however, anxiety-like profile persisted until late adulthood. Similarly, short-term memory was impaired in all withdrawal periods analysed, including late adult life. These behavioral data were associated with oxidative damage in midadulthood but not BDNF alterations. Taken together, the present work highlights the long-lasting emotional and cognitive alterations induced by ethanol binge drinking during adolescence, even after a long period of abstinence, which might impact adult life. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-11-21T14:43:06Z |
dc.date.available.fl_str_mv |
2022-11-21T14:43:06Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
QUEIROZ, Letícia Yoshitome et al. Repeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats. Oxidative Medicine and Cellular Longevity, v. 2022, article ID 7207755, p 1-11, Oct. 2022. DOI: https://doi.org/10.1155/2022/7207755. Disponível em: https://downloads.hindawi.com/journals/omcl/2022/7207755.pdf. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/6670 |
dc.identifier.issn.-.fl_str_mv |
1942-0994 |
dc.identifier.doi.-.fl_str_mv |
10.1155/2022/7207755 |
identifier_str_mv |
QUEIROZ, Letícia Yoshitome et al. Repeated cycles of binge-like ethanol exposure induces neurobehavioral changes during short- and long-term withdrawal in adolescent female rats. Oxidative Medicine and Cellular Longevity, v. 2022, article ID 7207755, p 1-11, Oct. 2022. DOI: https://doi.org/10.1155/2022/7207755. Disponível em: https://downloads.hindawi.com/journals/omcl/2022/7207755.pdf. 1942-0994 10.1155/2022/7207755 |
url |
https://patua.iec.gov.br/handle/iec/6670 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Hindawi |
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Hindawi |
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