Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | http://patua.iec.gov.br//handle/iec/4555 |
Resumo: | Abstract: The COVID-19 pandemic is the biggest public health threat facing the world today. Multiple vaccines have been approved; however, the emergence of viral variants such as the recent Omicron raises the possibility of booster doses to achieve adequate protection. In Brazil, the CoronaVac (Sinovac, Beijing, China) vaccine was used; however, it is important to assess the immune response to this vaccine over time. This study aimed to monitor the anti-SARS-CoV-2 antibody responses in those immunized with CoronaVac and SARS-CoV-2 infected individuals. Samples were collected between August 2020 and August 2021. Within the vaccinated cohort, some individuals had a history of infection by SARS-CoV-2 prior to immunization, while others did not. We analyzed RBD-specific and neutralizing-antibodies. Anti-RBD antibodies were detected in both cohorts, with a peak between 45–90 days post infection or vaccination, followed by a steady decline over time. In those with a previous history of COVID-19, a higher, longer, more persistent response was observed. This trend was mirrored in the neutralization assays, where infection, followed by immunization, resulted in higher, longer lasting responses which were conditioned on the presence of levels of RBD antibodies right before the vaccination. This supports the necessity of booster doses of CoronaVac in due course to prevent serious disease. |
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Oliveira, Camille F. deFranco Neto, Walter FelixSilva, Carla P. daRibeiro, Ana Claudia SantosMartins, Lívia CaricioSousa, Alana W. deFreitas, Maria N. OChiang, Jannifer OliveiraSilva, Franko ASantos, Eder B. dosMedeiros, Daniele Barbosa de AlmeidaPinheiro, Gleiciane SBrandão, Gleiciane FCarvalho, Valéria LimaAzevedo, Raimunda do Socorro da SilvaVasconcelos, Pedro Fernando da CostaCosta, Igor BrasilCosta, Iran BarrosSantos, Mirleide Cordeiro dosSoares, Luana da SilvaBedran, Rayssa L. SFerreira, James LAmarilla, Alberto AnastacioModhiran, NaphakMcMillan, Christopher L. DFreney, Morgan EMuller, David AWatterson, DanielCasseb, Lívia Medeiros NevesHenriques, Daniele Freitas2022-06-07T12:21:27Z2022-06-07T12:21:27Z2022OLIVEIRA, Camille F. de et al. Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration. Vaccines, v. 10, n. 5, p. 1-13, Apr. 2022.2076-393Xhttp://patua.iec.gov.br//handle/iec/455510.3390/vaccines10050690Abstract: The COVID-19 pandemic is the biggest public health threat facing the world today. Multiple vaccines have been approved; however, the emergence of viral variants such as the recent Omicron raises the possibility of booster doses to achieve adequate protection. In Brazil, the CoronaVac (Sinovac, Beijing, China) vaccine was used; however, it is important to assess the immune response to this vaccine over time. This study aimed to monitor the anti-SARS-CoV-2 antibody responses in those immunized with CoronaVac and SARS-CoV-2 infected individuals. Samples were collected between August 2020 and August 2021. Within the vaccinated cohort, some individuals had a history of infection by SARS-CoV-2 prior to immunization, while others did not. We analyzed RBD-specific and neutralizing-antibodies. Anti-RBD antibodies were detected in both cohorts, with a peak between 45–90 days post infection or vaccination, followed by a steady decline over time. In those with a previous history of COVID-19, a higher, longer, more persistent response was observed. This trend was mirrored in the neutralization assays, where infection, followed by immunization, resulted in higher, longer lasting responses which were conditioned on the presence of levels of RBD antibodies right before the vaccination. This supports the necessity of booster doses of CoronaVac in due course to prevent serious disease.Instituto Evandro Chagas, Ministry of Health—Brazil; University of Queensland—Australia.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilUniversity of Pará State. Department of Biological and Health Sciences. Belém, PA, BrazilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilThe University of Queensland. School of Chemistry and Molecular Biosciences. St Lucia, AustraliaThe University of Queensland. School of Chemistry and Molecular Biosciences. St Lucia, AustraliaThe University of Queensland. School of Chemistry and Molecular Biosciences. St Lucia, AustraliaThe University of Queensland. School of Chemistry and Molecular Biosciences. St Lucia, AustraliaThe University of Queensland. School of Chemistry and Molecular Biosciences. St Lucia, Australia / The University of Queensland. Australian Infectious Disease Research Centre. St Lucia, AustraliaThe University of Queensland. School of Chemistry and Molecular Biosciences. St Lucia, Australia / The University of Queensland. Australian Infectious Disease Research Centre. St Lucia, Australia / The University of Queensland. The Australian Institute for Biotechnology and Nanotechnology. St Lucia, AustraliaMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilengMDPIAbsence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months durationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSARS-CoV-2 / patogenicidadeCOVID-19Anticorpos / análiseVacinas contra COVID-19 / análiseTeste Sorológico para COVID-19CoronaVacinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAbsence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration.pdfAbsence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration.pdfapplication/pdf2062225https://patua.iec.gov.br/bitstreams/77acd1f3-4c26-4b86-9129-98631987f261/downloadb44a2c800a9be99aafae0f42768a3f3bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/f93cadfc-8135-4340-aa23-eb22739a2d83/download11832eea31b16df8613079d742d61793MD52TEXTAbsence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration.pdf.txtAbsence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration.pdf.txtExtracted texttext/plain57822https://patua.iec.gov.br/bitstreams/e0a00bdd-aef5-481d-98c1-651586109277/download02d38fb65093a9434bd4d9012319d7d0MD55THUMBNAILAbsence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration.pdf.jpgAbsence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration.pdf.jpgGenerated Thumbnailimage/jpeg5970https://patua.iec.gov.br/bitstreams/a6f3e1ae-f151-4c2b-8647-070ddd0a3445/download4cb4f9d11c84128a04bf9e88b3aae764MD56iec/45552023-09-29 12:10:31.212oai:patua.iec.gov.br:iec/4555https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-09-29T12:10:31Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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 |
dc.title.pt_BR.fl_str_mv |
Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration |
title |
Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration |
spellingShingle |
Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration Oliveira, Camille F. de SARS-CoV-2 / patogenicidade COVID-19 Anticorpos / análise Vacinas contra COVID-19 / análise Teste Sorológico para COVID-19 CoronaVac |
title_short |
Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration |
title_full |
Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration |
title_fullStr |
Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration |
title_full_unstemmed |
Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration |
title_sort |
Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration |
author |
Oliveira, Camille F. de |
author_facet |
Oliveira, Camille F. de Franco Neto, Walter Felix Silva, Carla P. da Ribeiro, Ana Claudia Santos Martins, Lívia Caricio Sousa, Alana W. de Freitas, Maria N. O Chiang, Jannifer Oliveira Silva, Franko A Santos, Eder B. dos Medeiros, Daniele Barbosa de Almeida Pinheiro, Gleiciane S Brandão, Gleiciane F Carvalho, Valéria Lima Azevedo, Raimunda do Socorro da Silva Vasconcelos, Pedro Fernando da Costa Costa, Igor Brasil Costa, Iran Barros Santos, Mirleide Cordeiro dos Soares, Luana da Silva Bedran, Rayssa L. S Ferreira, James L Amarilla, Alberto Anastacio Modhiran, Naphak McMillan, Christopher L. D Freney, Morgan E Muller, David A Watterson, Daniel Casseb, Lívia Medeiros Neves Henriques, Daniele Freitas |
author_role |
author |
author2 |
Franco Neto, Walter Felix Silva, Carla P. da Ribeiro, Ana Claudia Santos Martins, Lívia Caricio Sousa, Alana W. de Freitas, Maria N. O Chiang, Jannifer Oliveira Silva, Franko A Santos, Eder B. dos Medeiros, Daniele Barbosa de Almeida Pinheiro, Gleiciane S Brandão, Gleiciane F Carvalho, Valéria Lima Azevedo, Raimunda do Socorro da Silva Vasconcelos, Pedro Fernando da Costa Costa, Igor Brasil Costa, Iran Barros Santos, Mirleide Cordeiro dos Soares, Luana da Silva Bedran, Rayssa L. S Ferreira, James L Amarilla, Alberto Anastacio Modhiran, Naphak McMillan, Christopher L. D Freney, Morgan E Muller, David A Watterson, Daniel Casseb, Lívia Medeiros Neves Henriques, Daniele Freitas |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Camille F. de Franco Neto, Walter Felix Silva, Carla P. da Ribeiro, Ana Claudia Santos Martins, Lívia Caricio Sousa, Alana W. de Freitas, Maria N. O Chiang, Jannifer Oliveira Silva, Franko A Santos, Eder B. dos Medeiros, Daniele Barbosa de Almeida Pinheiro, Gleiciane S Brandão, Gleiciane F Carvalho, Valéria Lima Azevedo, Raimunda do Socorro da Silva Vasconcelos, Pedro Fernando da Costa Costa, Igor Brasil Costa, Iran Barros Santos, Mirleide Cordeiro dos Soares, Luana da Silva Bedran, Rayssa L. S Ferreira, James L Amarilla, Alberto Anastacio Modhiran, Naphak McMillan, Christopher L. D Freney, Morgan E Muller, David A Watterson, Daniel Casseb, Lívia Medeiros Neves Henriques, Daniele Freitas |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
SARS-CoV-2 / patogenicidade COVID-19 Anticorpos / análise Vacinas contra COVID-19 / análise Teste Sorológico para COVID-19 CoronaVac |
topic |
SARS-CoV-2 / patogenicidade COVID-19 Anticorpos / análise Vacinas contra COVID-19 / análise Teste Sorológico para COVID-19 CoronaVac |
description |
Abstract: The COVID-19 pandemic is the biggest public health threat facing the world today. Multiple vaccines have been approved; however, the emergence of viral variants such as the recent Omicron raises the possibility of booster doses to achieve adequate protection. In Brazil, the CoronaVac (Sinovac, Beijing, China) vaccine was used; however, it is important to assess the immune response to this vaccine over time. This study aimed to monitor the anti-SARS-CoV-2 antibody responses in those immunized with CoronaVac and SARS-CoV-2 infected individuals. Samples were collected between August 2020 and August 2021. Within the vaccinated cohort, some individuals had a history of infection by SARS-CoV-2 prior to immunization, while others did not. We analyzed RBD-specific and neutralizing-antibodies. Anti-RBD antibodies were detected in both cohorts, with a peak between 45–90 days post infection or vaccination, followed by a steady decline over time. In those with a previous history of COVID-19, a higher, longer, more persistent response was observed. This trend was mirrored in the neutralization assays, where infection, followed by immunization, resulted in higher, longer lasting responses which were conditioned on the presence of levels of RBD antibodies right before the vaccination. This supports the necessity of booster doses of CoronaVac in due course to prevent serious disease. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-06-07T12:21:27Z |
dc.date.available.fl_str_mv |
2022-06-07T12:21:27Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Camille F. de et al. Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration. Vaccines, v. 10, n. 5, p. 1-13, Apr. 2022. |
dc.identifier.uri.fl_str_mv |
http://patua.iec.gov.br//handle/iec/4555 |
dc.identifier.issn.-.fl_str_mv |
2076-393X |
dc.identifier.doi.-.fl_str_mv |
10.3390/vaccines10050690 |
identifier_str_mv |
OLIVEIRA, Camille F. de et al. Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration. Vaccines, v. 10, n. 5, p. 1-13, Apr. 2022. 2076-393X 10.3390/vaccines10050690 |
url |
http://patua.iec.gov.br//handle/iec/4555 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
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collection |
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