Isolation of Flaviviruses and Alphaviruses with encephalitogenic potential diagnosed by Evandro Chagas Institute (Pará, Brazil) in the period of 1954–2022: six decades of discoveries

• Autor(a) principal: Wanzeller, Ana Lucia Monteiro
• Data de Publicação: 2023
• Outros Autores: Silva, Fabio Silva da, Hernández, Leonardo Henrique Almeida, Barros, Landerson Junior Leopoldino, Freitas, Maria Nazaré Oliveira, Santos, Maissa Maia, Gonçalves, Ercília de Jesus, Pantoja, Jamilla Augusto Sousa, Lima, Creuza de Sousa, Lima, Maxwell Furtado, Costa, Luiz Roberto Oliveira, Chagas, Liliane Leal das, Silva, Iveraldo Ferreira, Cunha, Tania Cristina Alves da Silveira da, Nascimento, Bruna Lais Sena do, Vasconcelos, Helena Baldez, Rosa, Elizabeth Salbé Travassos da, Rodrigues, Sueli Guerreiro, Azevedo, Raimunda do Socorro da Silva, Martins, Lívia Carício, Casseb, Lívia Medeiros Neves, Chiang, Jannifer Oliviera, Nunes Neto, Joaquim Pinto, Cruz, Ana Cecília Ribeiro, Carvalho, Valéria Lima, Vasconcelos, Pedro Fernando da Costa, Silva, Eliana Vieira Pinto da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/6825
• topic: Arbovírus / isolamento & purificação; Encefalite por Arbovirus; Monitoramento Epidemiológico

Viruses with encephalitogenic potential can cause neurological conditions of clinical and epidemiological importance, such as Saint Louis encephalitis virus, Venezuelan equine encephalitis virus, Eastern equine encephalitis virus, Western equine encephalitis virus, Dengue virus, Zika virus, Chikungunya virus, Mayaro virus and West Nile virus. The objective of the present study was to determine the number of arboviruses with neuroinvasive potential isolated in Brazil that corresponds to the collection of viral samples belonging to the Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute (SAARB/IEC) of the Laboratory Network of National Reference for Arbovirus Diagnosis from 1954 to 2022. In the analyzed period, a total of 1,347 arbovirus samples with encephalitogenic potential were isolated from mice; 5,065 human samples were isolated exclusively by cell culture; and 676 viruses were isolated from mosquitoes. The emergence of new arboviruses may be responsible for diseases still unknown to humans, making the Amazon region a hotspot for infectious diseases due to its fauna and flora species characteristics. The detection of circulating arboviruses with the potential to cause neuroinvasive diseases is constant, which justifies the continuation of active epidemiological surveillance work that offers adequate support to the public health system regarding the virological diagnosis of circulating arboviruses in Brazil.