Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil

Detalhes bibliográficos
Autor(a) principal: Nunes, Márcio Roberto Teixeira
Data de Publicação: 2014
Outros Autores: Palacios, Gustavo, Faria, Nuno Rodrigues, Sousa Junior, Edivaldo Costa, Pantoja, Jamilla A, Rodrigues, Sueli Guerreiro, Carvalho, Valéria Lima, Medeiros, Daniele Barbosa de Almeida, Savji, Nazir, Baele, Guy, Suchard, Marc A, Lemey, Philippe, Vasconcelos, Pedro Fernando da Costa, Lipkin, W. Ian
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/1013
Resumo: Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. For all three serotypes, we estimated that the introduction of new lineages occurred within 7 to 10-year intervals. New lineages were most likely to be imported from the Caribbean region to the North and Northeast regions of Brazil, and then to disperse at a rate of approximately 0.5 km/day. Joint statistical analysis of evolutionary, epidemiological and ecological data indicates that aerial transportation of humans and/or vector mosquitoes, rather than Aedes aegypti infestation rates or geographical distances, determine dengue virus spread in Brazil.
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spelling Nunes, Márcio Roberto TeixeiraPalacios, GustavoFaria, Nuno RodriguesSousa Junior, Edivaldo CostaPantoja, Jamilla ARodrigues, Sueli GuerreiroCarvalho, Valéria LimaMedeiros, Daniele Barbosa de AlmeidaSavji, NazirBaele, GuySuchard, Marc ALemey, PhilippeVasconcelos, Pedro Fernando da CostaLipkin, W. Ian2016-01-26T11:40:28Z2016-01-26T11:40:28Z2014NUNES, Márcio Roberto Teixeira et al. Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil. Plos Neglected Tropical Diseases, v. 8, n. 4, p. 1-13, Apr. 2014. DOI: https://doi.org/10.1371/journal.pntd.0002769.1935-2735https://patua.iec.gov.br/handle/iec/101310.1371/journal.pntd.0002769Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. For all three serotypes, we estimated that the introduction of new lineages occurred within 7 to 10-year intervals. New lineages were most likely to be imported from the Caribbean region to the North and Northeast regions of Brazil, and then to disperse at a rate of approximately 0.5 km/day. Joint statistical analysis of evolutionary, epidemiological and ecological data indicates that aerial transportation of humans and/or vector mosquitoes, rather than Aedes aegypti infestation rates or geographical distances, determine dengue virus spread in Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.United States Army Medical Research Institute for Infectious Diseases. Center for Genomic Sciences. Maryland, USA / Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, USA.University of Oxford. Department of Zoology. Oxford, United Kingdom.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, USA.Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, USA.University of Oxford. Department of Zoology. Oxford, United Kingdom.University of Oxford. Department of Zoology. Oxford, United Kingdom.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Universidade do Estado do Pará. Belém, PA, Brazil.Columbia University. Mailman School of Public Health. Center for Infection and Immunity. 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dc.title.pt_BR.fl_str_mv Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil
title Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil
spellingShingle Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil
Nunes, Márcio Roberto Teixeira
Vírus da Dengue / isolamento & purificação
Estruturas Genéticas
title_short Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil
title_full Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil
title_fullStr Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil
title_full_unstemmed Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil
title_sort Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil
author Nunes, Márcio Roberto Teixeira
author_facet Nunes, Márcio Roberto Teixeira
Palacios, Gustavo
Faria, Nuno Rodrigues
Sousa Junior, Edivaldo Costa
Pantoja, Jamilla A
Rodrigues, Sueli Guerreiro
Carvalho, Valéria Lima
Medeiros, Daniele Barbosa de Almeida
Savji, Nazir
Baele, Guy
Suchard, Marc A
Lemey, Philippe
Vasconcelos, Pedro Fernando da Costa
Lipkin, W. Ian
author_role author
author2 Palacios, Gustavo
Faria, Nuno Rodrigues
Sousa Junior, Edivaldo Costa
Pantoja, Jamilla A
Rodrigues, Sueli Guerreiro
Carvalho, Valéria Lima
Medeiros, Daniele Barbosa de Almeida
Savji, Nazir
Baele, Guy
Suchard, Marc A
Lemey, Philippe
Vasconcelos, Pedro Fernando da Costa
Lipkin, W. Ian
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nunes, Márcio Roberto Teixeira
Palacios, Gustavo
Faria, Nuno Rodrigues
Sousa Junior, Edivaldo Costa
Pantoja, Jamilla A
Rodrigues, Sueli Guerreiro
Carvalho, Valéria Lima
Medeiros, Daniele Barbosa de Almeida
Savji, Nazir
Baele, Guy
Suchard, Marc A
Lemey, Philippe
Vasconcelos, Pedro Fernando da Costa
Lipkin, W. Ian
dc.subject.decsPrimary.pt_BR.fl_str_mv Vírus da Dengue / isolamento & purificação
Estruturas Genéticas
topic Vírus da Dengue / isolamento & purificação
Estruturas Genéticas
description Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. For all three serotypes, we estimated that the introduction of new lineages occurred within 7 to 10-year intervals. New lineages were most likely to be imported from the Caribbean region to the North and Northeast regions of Brazil, and then to disperse at a rate of approximately 0.5 km/day. Joint statistical analysis of evolutionary, epidemiological and ecological data indicates that aerial transportation of humans and/or vector mosquitoes, rather than Aedes aegypti infestation rates or geographical distances, determine dengue virus spread in Brazil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2016-01-26T11:40:28Z
dc.date.available.fl_str_mv 2016-01-26T11:40:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv NUNES, Márcio Roberto Teixeira et al. Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil. Plos Neglected Tropical Diseases, v. 8, n. 4, p. 1-13, Apr. 2014. DOI: https://doi.org/10.1371/journal.pntd.0002769.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/1013
dc.identifier.issn.-.fl_str_mv 1935-2735
dc.identifier.doi.pt_BR.fl_str_mv 10.1371/journal.pntd.0002769
identifier_str_mv NUNES, Márcio Roberto Teixeira et al. Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil. Plos Neglected Tropical Diseases, v. 8, n. 4, p. 1-13, Apr. 2014. DOI: https://doi.org/10.1371/journal.pntd.0002769.
1935-2735
10.1371/journal.pntd.0002769
url https://patua.iec.gov.br/handle/iec/1013
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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