Evidence for persistence of infectious agents in isolated human populations

Detalhes bibliográficos
Autor(a) principal: Black, Francis Lee
Data de Publicação: 1974
Outros Autores: Hierholzer, Walter J, Pinheiro, Francisco de Paula, Evans, Alfred S, Woodall, John P, Opton, Edward M, Emmons, Jean E, West, Bernice S, Edsall, Geoffrey, Downs, Wilbur G, Wallace, Gordon D
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/958
Resumo: More than 900 members of three Carib and four Kayapo Indian tribes, living on the periphery of the Amazon basin, have been studied for immunity to various viral, bacterial and protozoal agents. These tribes are isolated from the main Brazilian culture, and severaI had remained hostile and dependent on stone tools until less than 10 years prior to the study. The prevalence of antibodies to herpesvirus types 1 and 2, Epstein-Barr virus, cytomegalovirus, varicella and hepatitis B antigen was very high in every tribe studied. The age of acquisition of immunity was lower than in previously studied cosmopolitan communities. These agents seem to maintain a very stable relation with their host populations. Antibodies to measles, mumps, rubella, influenza Ao, A2 and B, parainfluenza 1, 2 and 3 and poliovirus 1 were nearly or totally absent from one or more tribes. When these antibodies were found in anyone who had not been outside the tribial area, they were usually found in nearly everyone over a specific age. These agents seem to maintain an unstable relation with their hosts, appearing only when introduced from the outside and then disappearing again. There was no evidence of smallpox in any tribe. Antibodies to the arboviruses (yellow fever viruses, Ilhéus, and Mayaro) were found with high frequency in certain areas. Prevalence of antibody to these viruses increased gradually with age, suggesting endemicitv of a different arder from that of the herpes group viruses. Antibody to Toxoplasma was absent from children but was frequently present in older adults. Antibody to treponema had a very high prevalence in the Kayapo tribes without evidence of pathology, suggesting that the parasite present in these communities was well adapted to its host. Malaria and tuberculosis, on the other hand, caused extensive and severe morbidity and threatened destruction of their host populations. Tetanus antibodies were virtually absent.
id IEC-2_92a5478286c344e5280ef691887788ed
oai_identifier_str oai:patua.iec.gov.br:iec/958
network_acronym_str IEC-2
network_name_str Repositório Digital do Instituto Evandro Chagas (Patuá)
repository_id_str
spelling Black, Francis LeeHierholzer, Walter JPinheiro, Francisco de PaulaEvans, Alfred SWoodall, John POpton, Edward MEmmons, Jean EWest, Bernice SEdsall, GeoffreyDowns, Wilbur GWallace, Gordon D2016-01-26T11:39:51Z2016-01-26T11:39:51Z1974BLACK, Francis L. et al. Evidence for persistence of infectious agents in isolated human populations. American Journal of Epidemiology, v. 100, n. 3, p. 230-250, 1974.0002-9262https://patua.iec.gov.br/handle/iec/958More than 900 members of three Carib and four Kayapo Indian tribes, living on the periphery of the Amazon basin, have been studied for immunity to various viral, bacterial and protozoal agents. These tribes are isolated from the main Brazilian culture, and severaI had remained hostile and dependent on stone tools until less than 10 years prior to the study. The prevalence of antibodies to herpesvirus types 1 and 2, Epstein-Barr virus, cytomegalovirus, varicella and hepatitis B antigen was very high in every tribe studied. The age of acquisition of immunity was lower than in previously studied cosmopolitan communities. These agents seem to maintain a very stable relation with their host populations. Antibodies to measles, mumps, rubella, influenza Ao, A2 and B, parainfluenza 1, 2 and 3 and poliovirus 1 were nearly or totally absent from one or more tribes. When these antibodies were found in anyone who had not been outside the tribial area, they were usually found in nearly everyone over a specific age. These agents seem to maintain an unstable relation with their hosts, appearing only when introduced from the outside and then disappearing again. There was no evidence of smallpox in any tribe. Antibodies to the arboviruses (yellow fever viruses, Ilhéus, and Mayaro) were found with high frequency in certain areas. Prevalence of antibody to these viruses increased gradually with age, suggesting endemicitv of a different arder from that of the herpes group viruses. Antibody to Toxoplasma was absent from children but was frequently present in older adults. Antibody to treponema had a very high prevalence in the Kayapo tribes without evidence of pathology, suggesting that the parasite present in these communities was well adapted to its host. Malaria and tuberculosis, on the other hand, caused extensive and severe morbidity and threatened destruction of their host populations. Tetanus antibodies were virtually absent.Yale University. Departament of Epidemiology and Public Health. New Haven, Conn.Yale University. Departament of Epidemiology and Public Health. New Haven, Conn.Ministério da Saúde. Fundação Instituto Oswaldo Cruz. Instituto Evandro Chagas. Belém, PA, Brasil.Yale University. Departament of Epidemiology and Public Health. New Haven, CO, USA.State of New York Dept of Health. Albany, NY, USAYale University. Departament of Epidemiology and Public Health. New Haven, CO, USA.Yale University. Departament of Epidemiology and Public Health. New Haven, CO, USA.State of New York Dept of Health. Albany, NY, USA.The Commonwealth of Massachusetts. State Laboratory Institute. Departament of Public Health. Boston, MA, USA.Yale University. Departament of Epidemiology and Public Health. New Haven, CO, USA.NIAID - Pacific Research Station. Honolulu, Hawaii.application/pdfengOxford University PressEvidence for persistence of infectious agents in isolated human populationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInfecção / diagnósticoInfecção / epidemiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALEvidence for persistence of infectious agents in isolated human populations .pdfapplication/pdf2874669https://patua.iec.gov.br/bitstreams/2fdc67dd-a2f9-43e0-b550-c6815cb3d7d4/download27b24019679290b7a3b389bc9d061205MD51TEXTfile_1.pdf.txtfile_1.pdf.txtExtracted texttext/plain63056https://patua.iec.gov.br/bitstreams/cd8919ff-a864-4527-be9c-0a1ab7e95e34/download57b753b3ced69ac6760135685ee73acdMD52Evidence for persistence of infectious agents in isolated human populations .pdf.txtEvidence for persistence of infectious agents in isolated human populations .pdf.txtExtracted texttext/plain63489https://patua.iec.gov.br/bitstreams/1dbc1c3d-4836-4df0-884b-104b0be52443/download42141b559e8d2469ece6fbb05859be05MD56THUMBNAILEvidence for persistence of infectious agents in isolated human populations .pdf.jpgEvidence for persistence of infectious agents in isolated human populations .pdf.jpgGenerated Thumbnailimage/jpeg7030https://patua.iec.gov.br/bitstreams/dbffd9c8-0c67-4866-bcbd-ab2be8af9f39/download58bc93d575808084a4d3ce12f07599baMD57LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/e2a53266-ba12-4bb2-9008-b70681f8fd00/download11832eea31b16df8613079d742d61793MD55iec/9582022-10-20 21:11:50.646oai:patua.iec.gov.br:iec/958https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:11:50Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falsePGI+TGljZW7Dp2EgZGUgRGlzdHJpYnVpw6fDo28gTsOjbyBFeGNsdXNpdmE8L2I+DQoNClRvZG8gZGVwb3NpdGFudGUgZGUgbWF0ZXJpYWwgbm8gUGF0dcOhIGRldmUgY29uY2VkZXIgYW8gSW5zdGl0dXRvIEV2YW5kcm8gQ2hhZ2FzIHVtYSBMaWNlbsOnYSBkZSBEaXN0cmlidWnDp8OjbyBOw6NvIEV4Y2x1c2l2YSBwYXJhIHRvcm5hciBlIG1hbnRlciBhY2Vzc8OtdmVpcyBvcyBzZXVzIGRvY3VtZW50b3MgZW0gZm9ybWF0byBkaWdpdGFsLiANCg0KQ29tIGEgY29uY2Vzc8OjbyBkZXNzYSBsaWNlbsOnYSBuw6NvIGV4Y2x1c2l2YSwgbyBkZXBvc2l0YW50ZSBjb250aW51YSBhIHJldGVyIHRvZG9zIG9zIGRpcmVpdG9zIGRlIGF1dG9yLg0KDQpBbyBhc3NpbmFyIGUgZW50cmVnYXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKQ0KDQphKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRlIHNldSBkb2N1bWVudG8uDQoNCmIpIENvbmNlZGUgYW8gSW5zdGl0dXRvIEV2YW5kcm8gQ2hhZ2FzIG8gZGlyZWl0byBuw6NvIGV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyIGUvb3UgZGlzdHJpYnVpciBubyA8Yj5QYXR1w6E8L2I+LCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgcG9yIHF1YWxxdWVyIG91dHJvIG1laW8uDQoNCmMpIERlY2xhcmEgcXVlIGF1dG9yaXphIG8gSW5zdGl0dXRvIEV2YW5kcm8gQ2hhZ2FzIGEgYXJxdWl2YXIgbWFpcyBkZSB1bWEgY8OzcGlhIGRlc3NlIGRvY3VtZW50byBlIGNvbnZlcnTDqi1sbywgc2VtIGFsdGVyYXIgbyBzZXUgY29udGXDumRvLCBwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgZmljaGVpcm8sIG1laW8gb3Ugc3Vwb3J0ZSwgcGFyYSBlZmVpdG9zIGRlIHNlZ3VyYW7Dp2EsIHByZXNlcnZhw6fDo28gKGJhY2t1cCkgZSBhY2Vzc28uDQoNCmQpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCBlIHF1ZSBkZXTDqW0gbyBkaXJlaXRvIGRlIGNvbmNlZGVyIGEgdGVyY2Vpcm9zIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuDQoNCmUpIERlY2xhcmEgcXVlLCBubyBjYXNvIGRvIGRvY3VtZW50byBzdWJtZXRpZG8gY29udGVyIG1hdGVyaWFsIGRvIHF1YWwgbsOjbyBkZXTDqW0gb3MgZGlyZWl0b3MgZGUgYXV0b3IsIG9idGV2ZSBhIGF1dG9yaXphw6fDo28gaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhbyBJbnN0aXR1dG8gRXZhbmRybyBDaGFnYXMgb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIHV0aWxpesOhLWxvcyBsZWdhbG1lbnRlLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBjb250ZcO6ZG8gZG8gZG9jdW1lbnRvIGVudHJlZ3VlLg0KDQpmKSBTRSBPIERPQ1VNRU5UTyBFTlRSRUdVRSBGT1IgQkFTRUFETyBFTSBUUkFCQUxITyBGSU5BTkNJQURPIE9VIEFQT0lBRE8gUE9SIE9VVFJBIElOU1RJVFVJw4fDg08gUVVFIE7Dg08gTyBJTlNUSVRVVE8gRVZBTkRSTyBDSEFHQVMsIERFQ0xBUkEgUVVFIENVTVBSSVUgUVVBSVNRVUVSIE9CUklHQcOHw5VFUyBFWElHSURBUyBQRUxPIFJFU1BFQ1RJVk8gQ09OVFJBVE8gT1UgQUNPUkRPLg0KDQpPIEluc3RpdHV0byBFdmFuZHJvIENoYWdhcyBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgbyhzKSBub21lKHMpIGRvKHMpIGF1dG9yKGVzKSBkb3MgZGlyZWl0b3MgZG8gZG9jdW1lbnRvIGVudHJlZ3VlIGUgbsOjbyBmYXLDoSBxdWFscXVlciBhbHRlcmHDp8OjbyBhbMOpbSBkbyBwcmV2aXN0byBuYSBhbMOtbmVhIGIpLg==
dc.title.pt_BR.fl_str_mv Evidence for persistence of infectious agents in isolated human populations
title Evidence for persistence of infectious agents in isolated human populations
spellingShingle Evidence for persistence of infectious agents in isolated human populations
Black, Francis Lee
Infecção / diagnóstico
Infecção / epidemiologia
title_short Evidence for persistence of infectious agents in isolated human populations
title_full Evidence for persistence of infectious agents in isolated human populations
title_fullStr Evidence for persistence of infectious agents in isolated human populations
title_full_unstemmed Evidence for persistence of infectious agents in isolated human populations
title_sort Evidence for persistence of infectious agents in isolated human populations
author Black, Francis Lee
author_facet Black, Francis Lee
Hierholzer, Walter J
Pinheiro, Francisco de Paula
Evans, Alfred S
Woodall, John P
Opton, Edward M
Emmons, Jean E
West, Bernice S
Edsall, Geoffrey
Downs, Wilbur G
Wallace, Gordon D
author_role author
author2 Hierholzer, Walter J
Pinheiro, Francisco de Paula
Evans, Alfred S
Woodall, John P
Opton, Edward M
Emmons, Jean E
West, Bernice S
Edsall, Geoffrey
Downs, Wilbur G
Wallace, Gordon D
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Black, Francis Lee
Hierholzer, Walter J
Pinheiro, Francisco de Paula
Evans, Alfred S
Woodall, John P
Opton, Edward M
Emmons, Jean E
West, Bernice S
Edsall, Geoffrey
Downs, Wilbur G
Wallace, Gordon D
dc.subject.decsPrimary.pt_BR.fl_str_mv Infecção / diagnóstico
Infecção / epidemiologia
topic Infecção / diagnóstico
Infecção / epidemiologia
description More than 900 members of three Carib and four Kayapo Indian tribes, living on the periphery of the Amazon basin, have been studied for immunity to various viral, bacterial and protozoal agents. These tribes are isolated from the main Brazilian culture, and severaI had remained hostile and dependent on stone tools until less than 10 years prior to the study. The prevalence of antibodies to herpesvirus types 1 and 2, Epstein-Barr virus, cytomegalovirus, varicella and hepatitis B antigen was very high in every tribe studied. The age of acquisition of immunity was lower than in previously studied cosmopolitan communities. These agents seem to maintain a very stable relation with their host populations. Antibodies to measles, mumps, rubella, influenza Ao, A2 and B, parainfluenza 1, 2 and 3 and poliovirus 1 were nearly or totally absent from one or more tribes. When these antibodies were found in anyone who had not been outside the tribial area, they were usually found in nearly everyone over a specific age. These agents seem to maintain an unstable relation with their hosts, appearing only when introduced from the outside and then disappearing again. There was no evidence of smallpox in any tribe. Antibodies to the arboviruses (yellow fever viruses, Ilhéus, and Mayaro) were found with high frequency in certain areas. Prevalence of antibody to these viruses increased gradually with age, suggesting endemicitv of a different arder from that of the herpes group viruses. Antibody to Toxoplasma was absent from children but was frequently present in older adults. Antibody to treponema had a very high prevalence in the Kayapo tribes without evidence of pathology, suggesting that the parasite present in these communities was well adapted to its host. Malaria and tuberculosis, on the other hand, caused extensive and severe morbidity and threatened destruction of their host populations. Tetanus antibodies were virtually absent.
publishDate 1974
dc.date.issued.fl_str_mv 1974
dc.date.accessioned.fl_str_mv 2016-01-26T11:39:51Z
dc.date.available.fl_str_mv 2016-01-26T11:39:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BLACK, Francis L. et al. Evidence for persistence of infectious agents in isolated human populations. American Journal of Epidemiology, v. 100, n. 3, p. 230-250, 1974.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/958
dc.identifier.issn.-.fl_str_mv 0002-9262
identifier_str_mv BLACK, Francis L. et al. Evidence for persistence of infectious agents in isolated human populations. American Journal of Epidemiology, v. 100, n. 3, p. 230-250, 1974.
0002-9262
url https://patua.iec.gov.br/handle/iec/958
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Digital do Instituto Evandro Chagas (Patuá)
instname:Instituto Evandro Chagas (IEC)
instacron:IEC
instname_str Instituto Evandro Chagas (IEC)
instacron_str IEC
institution IEC
reponame_str Repositório Digital do Instituto Evandro Chagas (Patuá)
collection Repositório Digital do Instituto Evandro Chagas (Patuá)
bitstream.url.fl_str_mv https://patua.iec.gov.br/bitstreams/2fdc67dd-a2f9-43e0-b550-c6815cb3d7d4/download
https://patua.iec.gov.br/bitstreams/cd8919ff-a864-4527-be9c-0a1ab7e95e34/download
https://patua.iec.gov.br/bitstreams/1dbc1c3d-4836-4df0-884b-104b0be52443/download
https://patua.iec.gov.br/bitstreams/dbffd9c8-0c67-4866-bcbd-ab2be8af9f39/download
https://patua.iec.gov.br/bitstreams/e2a53266-ba12-4bb2-9008-b70681f8fd00/download
bitstream.checksum.fl_str_mv 27b24019679290b7a3b389bc9d061205
57b753b3ced69ac6760135685ee73acd
42141b559e8d2469ece6fbb05859be05
58bc93d575808084a4d3ce12f07599ba
11832eea31b16df8613079d742d61793
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)
repository.mail.fl_str_mv clariceneta@iec.gov.br || Biblioteca@iec.gov.br
_version_ 1809190035492175872