Concomitant rotavirus serotypes 1 and 4 infections in a diarrhoeic child from Belém, Brazil

• Autor(a) principal: Mascarenhas, Joana D'Arc Pereira
• Data de Publicação: 1996
• Outros Autores: Gusmão, R. H. P, Gabbay, Yvone Benchimol, Monteiro, Talita Antonia Furtado, Gomes, J. B, Linhares, Alexandre da Costa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/948
• topic: Rotavirus / classificação; Ensaio de Imunoadsorção Enzimática / métodos; Vacinas contra Rotavirus; Infecções por Rotavirus / patologia; Sintomas Concomitantes

Concomitant serotypes 1 and 4 infections were detected in a 15-month old female child with community-acquired diarrhoea which lasted 7 days and coursed with moderate dehydration. The evidence for dual rotavirus infection was offered by the following findings: a) enzyme-linked immunosorbent assay (ELISA) positive reactions to both 1 and 4 serotypes; and b) extra-migrating bands at electrophoresis of RNA in polyacrylamide gel (PAGE). These results suggest that children living under poor sanitation conditions are heavily exposed to rotavirus infections; in addition, the co-circulation of different serotypes in the same setting sustains the current concept that a rotavirus vaccine should be multivalent, in order to protect children against the four epidemiologically important rotavirus G serotypes.