Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus

Detalhes bibliográficos
Autor(a) principal: Sawada, Leila
Data de Publicação: 2021
Outros Autores: Vallinoto, Antonio Carlos Rosário, Costa, Igor Brasil
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: http://patua.iec.gov.br//handle/iec/4499
Resumo: Epstein–Barr virus (EBV) is an oncovirus ubiquitously distributed and associated with different types of cancer. The reason why only a group of infected people develop cancer is still unknown. EBV-associated cancers represent about 1.8% of all cancer deaths worldwide, with more than 150,000 new cases of cancer being reported annually. Since EBV-associated cancers are described as more aggressive and more resistant to the usual treatment compared to EBV-negative ones, the recent introduction of monoclonal antibodies (mAbs) targeting immune checkpoints (ICs) in the treatment of cancer patients represents a possible therapy for EBV-associated diseases. However, the current mAb therapies available still need improvement, since a group of patients do not respond well to treatment. Therefore, the main objective of this review is to summarize the progress made regarding the contribution of EBV infection to the expression of the IC indoleamine 2,3-dioxygenase (IDO) thus far. This IC has the potential to be used as a target in new immune therapies, such as mAbs. We hope that this work helps the development of future immunotherapies, improving the prognosis of EBV-associated cancer patients
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spelling Sawada, LeilaVallinoto, Antonio Carlos RosárioCosta, Igor Brasil2022-05-13T12:27:19Z2022-05-13T12:27:19Z2021SAWADA, Leila; VALLINOTO, Antônio Carlos Rosário; COSTA, Igor Brasil. Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus. Biomolecules, v. 11, n. 12, p. 1-13, Nov. 2021.2218-273Xhttp://patua.iec.gov.br//handle/iec/449910.3390/biom11121792Epstein–Barr virus (EBV) is an oncovirus ubiquitously distributed and associated with different types of cancer. The reason why only a group of infected people develop cancer is still unknown. EBV-associated cancers represent about 1.8% of all cancer deaths worldwide, with more than 150,000 new cases of cancer being reported annually. Since EBV-associated cancers are described as more aggressive and more resistant to the usual treatment compared to EBV-negative ones, the recent introduction of monoclonal antibodies (mAbs) targeting immune checkpoints (ICs) in the treatment of cancer patients represents a possible therapy for EBV-associated diseases. However, the current mAb therapies available still need improvement, since a group of patients do not respond well to treatment. Therefore, the main objective of this review is to summarize the progress made regarding the contribution of EBV infection to the expression of the IC indoleamine 2,3-dioxygenase (IDO) thus far. This IC has the potential to be used as a target in new immune therapies, such as mAbs. We hope that this work helps the development of future immunotherapies, improving the prognosis of EBV-associated cancer patientsEvandro Chagas InstituteMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Imunologia. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Pós-Graduação em Virologia. Ananindeua, PA, BrasilFederal University of Pará. Institute of Biological Sciences. Virology Laboratory. Belém, PA, BrazilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Imunologia. Ananindeua, PA, BrasilengMDPIRegulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHerpesvirus Humano 4 / diagnósticoInfecções por Vírus Epstein-BarrNeoplasias / terapiaIndolamina-Pirrol 2,3,-DioxigenaseTécnicas Imunológicas / métodosinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALRegulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus.pdfRegulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus.pdfapplication/pdf850617https://patua.iec.gov.br/bitstreams/6f9cafe8-2d0a-4eea-8b05-9b09c4a801f4/download52cd857f6830762962d08172b583157dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/f43b55af-e2aa-4568-ad1e-1275e72ea8b7/download11832eea31b16df8613079d742d61793MD52TEXTRegulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus.pdf.txtRegulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus.pdf.txtExtracted texttext/plain72261https://patua.iec.gov.br/bitstreams/5306a110-51b0-4f51-8133-9f5a42a97d6d/download9498fe55891014c18e2d4d534287b3d5MD55THUMBNAILRegulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus.pdf.jpgRegulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus.pdf.jpgGenerated Thumbnailimage/jpeg5710https://patua.iec.gov.br/bitstreams/c0c183b6-166b-4303-9ce8-c67f95c14f31/download0460e77303d0b04f5e075e32cc6e6171MD56iec/44992023-03-13 11:34:51.206oai:patua.iec.gov.br:iec/4499https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-03-13T11:34:51Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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
dc.title.pt_BR.fl_str_mv Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus
title Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus
spellingShingle Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus
Sawada, Leila
Herpesvirus Humano 4 / diagnóstico
Infecções por Vírus Epstein-Barr
Neoplasias / terapia
Indolamina-Pirrol 2,3,-Dioxigenase
Técnicas Imunológicas / métodos
title_short Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus
title_full Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus
title_fullStr Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus
title_full_unstemmed Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus
title_sort Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus
author Sawada, Leila
author_facet Sawada, Leila
Vallinoto, Antonio Carlos Rosário
Costa, Igor Brasil
author_role author
author2 Vallinoto, Antonio Carlos Rosário
Costa, Igor Brasil
author2_role author
author
dc.contributor.author.fl_str_mv Sawada, Leila
Vallinoto, Antonio Carlos Rosário
Costa, Igor Brasil
dc.subject.decsPrimary.pt_BR.fl_str_mv Herpesvirus Humano 4 / diagnóstico
Infecções por Vírus Epstein-Barr
Neoplasias / terapia
Indolamina-Pirrol 2,3,-Dioxigenase
Técnicas Imunológicas / métodos
topic Herpesvirus Humano 4 / diagnóstico
Infecções por Vírus Epstein-Barr
Neoplasias / terapia
Indolamina-Pirrol 2,3,-Dioxigenase
Técnicas Imunológicas / métodos
description Epstein–Barr virus (EBV) is an oncovirus ubiquitously distributed and associated with different types of cancer. The reason why only a group of infected people develop cancer is still unknown. EBV-associated cancers represent about 1.8% of all cancer deaths worldwide, with more than 150,000 new cases of cancer being reported annually. Since EBV-associated cancers are described as more aggressive and more resistant to the usual treatment compared to EBV-negative ones, the recent introduction of monoclonal antibodies (mAbs) targeting immune checkpoints (ICs) in the treatment of cancer patients represents a possible therapy for EBV-associated diseases. However, the current mAb therapies available still need improvement, since a group of patients do not respond well to treatment. Therefore, the main objective of this review is to summarize the progress made regarding the contribution of EBV infection to the expression of the IC indoleamine 2,3-dioxygenase (IDO) thus far. This IC has the potential to be used as a target in new immune therapies, such as mAbs. We hope that this work helps the development of future immunotherapies, improving the prognosis of EBV-associated cancer patients
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-05-13T12:27:19Z
dc.date.available.fl_str_mv 2022-05-13T12:27:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SAWADA, Leila; VALLINOTO, Antônio Carlos Rosário; COSTA, Igor Brasil. Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus. Biomolecules, v. 11, n. 12, p. 1-13, Nov. 2021.
dc.identifier.uri.fl_str_mv http://patua.iec.gov.br//handle/iec/4499
dc.identifier.issn.-.fl_str_mv 2218-273X
dc.identifier.doi.-.fl_str_mv 10.3390/biom11121792
identifier_str_mv SAWADA, Leila; VALLINOTO, Antônio Carlos Rosário; COSTA, Igor Brasil. Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus. Biomolecules, v. 11, n. 12, p. 1-13, Nov. 2021.
2218-273X
10.3390/biom11121792
url http://patua.iec.gov.br//handle/iec/4499
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collection Repositório Digital do Instituto Evandro Chagas (Patuá)
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